Japan Science and Technology Agency. Metabolism and cellular Function PRESTO
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Research Reports
Ikuo Abe
Authors She-Po Shi, Hiroyuki Morita, Kiyofumi Wanibuchi, Hiroshi Noguchi, Ikuro Abe
Title Novel Type III Polyketide Synthases from Aloe arborescens
Publication FEBS J., vol. 276, 2391-2401 (2009)

Authors Yuusuke Mizuuchi, She-Po Shi, Kiyofumi Wanibuchi, Akiko Kojima, Hiroyuki Morita, Hiroshi Noguchi, Ikuro Abe
Title Enzymatic Formation of Unnatural Novel Polyketide Scaffolds by Plant Type III Polyketide Synthase
Publication Tetrahedron Letters, vol. 50, 2150-2153 (2009)

Authors She-Po Shi, K. Wanibuchi, H. Morita, K. Endo, H. Noguchi, I. Abe
Title Enzymatic Formation of Unnatural Novel Chalcone, Stilbene, and Benzophenone Scaffolds by Plant Type III Polyketide Synthase
Publication Organic Letters, vol. 11, 551-554 (2009)

Authors Yuusuke Mizuuchi, Yoshihiko Shimokawa, Kiyofumi Wanibuchi, Hiroshi Noguchi, Ikuro Abe
Title Structure Function Analysis of Novel Type III Polyketide Syntheases from Arabidopsis thaliana
Publication Bio. Pharm. Bull., vol. 31, 2205-2210 (2008)

Authors I. Abe
Title Engineered Biosynthesis of Natural Products
Publication Chem. Pharm. Bull., vol. 56, 1505-1514 (2008)

Authors Hiroyuki Morita, Michikazu Tanio, Shin Kondo, Ryohei Kato, Kiyofumi Wanibuchi, Hiroshi Noguchi, Shigetoshi Sugio, Ikuro Abe, Toshiyuki Kohno
Title Crystal Structure of a Plant Type III Polyketide Synthase that Produce Benzalacetone
Publication 5th International Conference on Plant Metabolomics, Yokohama, Japan (2008/7/15)

Authors I. Abe
Title Engineered Biosynthesis of Plant Polyketides
Publication 7th Japan-US Seminar, Biosynthesis of Natural Products, "Enzymology, Structural Biology, and Drug Discovery", San Diego, USA (2008/6/22)

Authors I. Abe
Title Engineered Biosynthesis of Plant Polyphenols
Publication 4th Japan-Korea-China Joint Seminar on Pharmacognosy, Gangneung, Korea (2008/6/19)

Authors S. Shi, H. Morita, K. Wanibuchi, Y. Mizuuchi, H. Noguchi, I. Abe
Title Enzymatic Synthesis of Plant Polyketides
Publication Curr. Org. Synth., vol. 5, 250-266 (2008)

Authors H. Morita, M. Tanio, S. Kondo, R. Kato, K. Wanibuchi, H. Noguchi, S. Sugio, I. Abe, T. Kohno
Title Crystallization and Preliminary Crystallographic Analysis of a Plant Type III Polyketide Synthase that Produces Benzalacetone
Publication Acta Crystallogr., F64, 304-306 (2008)

Authors H. Morita, Y. Mizuuchi, , T. Abe, T. Kohno, H. Noguchi, I. Abe
Title Cloning and Functional Analysis of a Novel Aldo-Keto Reductase from Aloe arborescens
Publication Biol. Pharm. Bull., vol. 30, 2262-2267 (2007)

Authors H. Morita, S. Kondo, R. Kato, K. Wanibuchi, H. Noguchi, S. Sugio, I. Abe, T. Kohno
Title Crystallization and Preliminary Crystallographic Analysis of an Octaketide-Producing Plant Type III Polyketide Synthase
Publication Acta Crystallogr., F63, 947-949 (2007)

Authors H. Morita, S. Kondo, R. Kato, K. Wanibuchi, H. Noguchi, S. Sugio, I. Abe, T. Kohno
Title Crystallization and Preliminary Crystallographic Analysis of an Acridone-Producing Novel Multifunctional Type III Polyketide Synthase from Huperzia serrata
Publication Acta Crystallogr., F63, 576-578 (2007)

Authors T. Abe, H. Morita, H. Noma, T. Kohno, H. Noguchi, I. Abe
Title Structure Function Analysis of Benzalacetone Synthase from Rheum palmatum
Publication Bioorg. Med. Chem. Lett., vol. 17, 3161-3166 (2007)

Authors I. Abe
Title Enzymatic Synthesis of Cyclic Triterpenes
Publication Nat. Prod. Rep., vol. 24, 1311-1331 (2007)

Authors Hiroyuki Morita, Shin Kondo, Satoshi Oguro, Hiroshi Noguchi, Shigetoshi Sugio, Ikuro Abe, Toshiyuki Kohno
Title Structural insight into chain length control and product specificity of pentaketide chromone synthase from Aloe arborescens
Publication Chemistry & Biology, vol. 14, 359-369 (2007)

Authors Ikuro Abe, Hiroyuki Morita, Satoshi Oguro, Hisashi Noma, Kiyofumi Wanibuchi, Nobuo Kawahara, Yukihiro Goda, Hiroshi Noguchi, Toshiyuki Kohno
Title Structure-Based Engineering of a Plant Type III Polyketide Synthase: Formation of an Unnatural Nonaketide Naphthopyrone
Publication J. Am. Chem. Soc., vol. 129, 5976-5980 (2007)

Authors Ikuro Abe
Title Enzymatic Synthesis of Cyclic Triterpenes
Publication TERPNET 2007 8th International Meeting on Biosynthesis and Function of Isoprenoids, Strasbourg, France (2007/4/30-5/4)

Authors Kiyofumi Wanibuchi, Ping Zhang, Tsuyoshi Abe, Hiroyuki Morita, Toshiyuki Kohno, Guoshin Chen, Hiroshi Noguchi, Ikuro Abe
Title An Acridone-Producing Novel Multifunctional Type III Polyketide Synthase from Huperzia serrata
Publication FEBS J., vol. 274, 1073-1082 (2007)

Authors Ikuro Abe, Hideya Tanaka, Tsuyoshi Abe, Hiroshi Noguchi
Title Enzymatic Formation of Unnatural Cytokinin Analogs by Adenylate Isopentenyl- transferase from Mulberry
Publication Biochem. Biophys. Res. Commun., vol. 355, 795-800 (2007)

Authors Ikuro Abe, Tsuyoshi Abe, Weiwei Lou, Takayoshi Masuoka, Hiroshi Noguchi
Title Site-directed Mutagenesis of Conserved Aromatic Residues in Rat Squalene Epoxidase Yielded Mutants with Altered Substrate and Product Specificities
Publication Biochem. Biophys. Res. Commun., vol. 352, 259-263 (2007)

Authors Ikuro Abe
Title Engineered Biosynthesis of Plant Polyketides
Publication ACS Symposium Series #955, Polyketides: Synthesis, Biological Activity and Genetic Engineering, S. Baerson and A. Rimando, eds., American Chemical Society, Washington, DC, 109-127 (2007)

Authors Tsuyoshi Abe, Hisashi, Noma, Hiroshi Noguchi, Ikuro Abe
Title Enzymatic Formation of an Unnatural Methylated Triketide by Plant Type III Polyketide Synthases
Publication Tetrahedron Lett., vol. 47, 8727-8730 (2006)

Authors Hiroyukik Morita, Shin Kondo, Tsuyoshi Abe, Hiroshi Noguchi, Shigetoshi Sugio, Ikuro Abe, Toshiyuki Kohno
Title Crystallization and Preliminary Crystallographic Analysis of A novel Plant Type III Polyketide Synthase That Produces Pentaketide Chromone
Publication Acta Cryst. F62, 899-901 (2006)

Authors Ikuro Abe, Tsuyoshi Abe, Kiyofumi Wanibuchi, Hiroshi Noguchi
Title Enzymatic Formation of Quinolone Alkaloids by a Plant Type III Polyketide Synthase
Publication Org. Lett., vol. 8, 6063-6065 (2006)

Authors Ikuro Abe
Title Engineered Biosynthesis of Plant Polyketides
Publication ICOB-5 & ISCNP-25 IUPAC International Conference on Biodiversity and Natural Products, Kyoto, Japan (2006/7/27)

Authors Hisashi Noma, Hideya Tanaka, Hiroshi Noguchi, Ikuro Abe
Title Enzymatic Synthesis of Unnatural Novel Cyclic Polyprenoids by Bacterial Squalene Cyclase
Publication 232nd American Chemical Society National Meeting & Exposition, San Francisco, CA, USA (2006/9/10-14)

Authors Tsuyoshi Abe, Satoshi Oguro, Hiroshi Noguchi, Ikuro Abe
Title Engineered Biosynthesis of Plant Polyketides
Publication 232nd American Chemical Society National Meeting & Exposition, San Francisco, CA, USA (2006/9/10-14)

Authors Tsuyoshi Abe, Hiroyuki Morita, Ikuro Abe, Atsushi Hoshino, Shigeru Iida, and Hiroshi Noguchi
Title Function of CHS-A and CHS-B in Ipomoea purpurea
Publication ICOB-5 & ISCNP-25 IUPAC International Conference on Biodiversity and Natural Products, Kyoto, Japan (2006/7/23-28)

Authors Ikuro Abe, Hisashi Noma, Hideya Tanaka, Hiroshi Noguchi
Title ENGINEERED BIOSYNTHSIS OF "SUPRANATURAL STEROIDS"
Publication ICOB-5 & ISCNP-25 IUPAC International Conference on Biodiversity and Natural Products, Kyoto, Japan (2006/7/23-28)

Authors Ikuro Abe, Satoshi Oguro, Tatsuya Watanabe, Hiroshi Noguchi
Title ENGINEERED BIOSYNTHESIS OF PLANT POLYKETIDES
Publication ICOB-5 & ISCNP-25 IUPAC International Conference on Biodiversity and Natural Products, Kyoto, Japan (2006/7/23-28)

Authors Kazunari Kondo, Asako Watanabe, Yuko Iwanaga, Ikuro Abeb, Hideya Tanaka, Megumi Hamano Nagaoka, Hiroshi Akiyama, Tamio Maitani
Title Analysis of agaritine in mushrooms and in agaritine-administered mice using liquid chromatography-tandem mass spectrometry
Publication Journal of Chromatography B, vol. 834, 55-61 (2006)

Authors Hideya Tanaka, Hisashi Noma, Hiroshi Noguchi, Ikuro Abe
Title Enzymatic formation of pyrrole-containing novel cyclic polyprenoids by bacterial squalene:hopene cyclase
Publication Tetrahedron Letters, vol. 47, 3085-3089 (2006)

Authors Ikuro Abe, Tatsuya Watanabe, Hiroyuki Morita, Toshiyuki Kohno, Hiroshi Noguchi
Title Engineered Biosynthesis of Plant Polyketides by Chalcone Synthase
Publication Org. Lett., vol. 8, 499-502 (2006)

AuthorsMasayuki Mori, Guixin Li, Ikuro Abe, Jun Nakayama, Zhanjun Guo, Jinko Sawashita, Tohru Ugawa, Shoko Nishizono, Tadao Serikawa, Keiichi Higuchi, Seigo Shumiya
TitleLanosterol synthase mutations cause cholesterol deficiency-associated cataracts in the Shumiya cataract rat
PublicationJ. Clin. Invest., vol. 116, 395-404 (2006)

AuthorsIkuro Abe, Tatsuya Watanabe, Hiroshi Noguchi
TitleChalcone Synthase Superfamily of Type III Polyketide Synthases from Rhubarb (Rheum palmatum)
PublicationProc. Japan Acad., Ser. B, vol. 81, 434-440 (2005)

AuthorsIkuro Abe, Tatsuya Watanabe, Weiwei Lou, Hiroshi Noguchi
TitleActive site residues governing substrate selectivity and polyketide chain length in aloesone synthase
PublicationFEBS Journal, vol. 273, 208-218 (2006)

AuthorsHideya Tanaka, Hiroshi Noguchi, Ikuro Abe
TitleEnzymatic Formation of Indole-Containing Unnatural Cyclic Polyprenoids by Bacterial Squalene:Hopene Cyclase
PublicationOrg. Lett. , vol. 7, 5873-5876 (2005)

AuthorsIkuro Abe
TitleStructure and function of plant type III polyketide synthases
PublicationInternational Chemical Congress of Pacific Basin Societies (PACIFICHEM 2005), Symposium on "Natural Product Biosynthesis", Honolulu, Hawaii, USA (2005/12/15-20)

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