Metabolomic analysis of heart failure and cardiac senescence
The heart failure increases dramatically with age. Heart is a postmitotic organ, therefore, myocardial aging, such as under repeated oxidative stress, is characterized by a loss of specialized cellular functions. The final avenue of exploration in understanding cellular function is the metabolites that occur as the end products of cellular metabolism (metabolome). The change of cardiac metabolites, along with improper degradation and synthesis of cellular proteins, may lead to myocardial aging. Through the integration of metabolome with transcriptome with proteome, we try to understand the cellular and molecular mechanism of heart failure, especially in the context of myocardial aging.
