| 著者・発表者 | Satoshi Obika, Masaharu Tomizu, Yoshinori Negoro, Ayako Orita, Osamu Nakagawa, and Takeshi Imanish |
| 表題 | Double-Stranded DNA-Templated Oligonucleotide Digestion Triggered by Triplex Formation |
| 発表先 |
XIVth Symposium on Chemistry of Nucleic Acid Components |
| | |
| 著者・発表者 | M. Kuwahara, S. Obika, J. Nagashima, Y. Ohta, Y. Suto, H. Ozaki, H. Sawai and T. Imanishi |
| 表題 | Systematic Analysis of Enzymatic DNA Polymerization Using Oligo-DNA Templates and Triphosphate Analogs Involving 2’,4’-Bridged Nucleosides |
| 発表先 |
Nucleic Acids Res., 36, 4257-4265 (2008). |
| | |
| 著者・発表者 | S. Obika, S. M. A. Rahman, B. Song, M. Onoda, M. Koizumi, K. Morita and T. Imanishi |
| 表題 | Synthesis and Properties of 3’-Amino-2’,4’-BNA, A Bridged Nucleic Acid with a N3’→P5’ Phosphoramidate Linkage |
| 発表先 | Bioorg. Med. Chem., 16, 9230-9237 (2008). |
| | |
| 著者・発表者 | Y. Mitsuoka, T. Kodama, R. Ohnishi, Y. Hari, T. Imanishi and S. Obika |
| 表題 | A Bridged Nucleic Acid, 2’,4’-BNACOC: Synthesis of Fully Modified Oligonucleotides Bearing Thymine, 5-Methylcytosine, Adenine and Guanine 2’,4’-BNACOC Monomers, and RA-selective Nucleic Acid Recognition |
| 発表先 |
Nucleic Acids Res., 37, 1225-1238 (2009). |
| | |
| 著者・発表者 | 今西 武, 小比賀 聡 |
| 表題 | BNA(LNA)オリゴを用いるアンチセンス法 |
| 発表先 | RNAiとアンチセンス法, 関根 光雄, 多比良 和誠 (編), 199-210, 講談社サイエンティフィク (2005). |
| | |
| 著者・発表者 | M. Warashina, B. Nawrot, S. Obika, L. A. Woniak, T. Kuwabara, T. Imanishi, W. J. Stec and K. Taira |
| 表題 | Effect of Modifications on the Intracellular Activity of a DNA Enzyme |
| 発表先 |
“Synthetic Nucleic Acids as Inhibitors of Gene Expression,” L. M. Khachigian Ed., pp 95-113, CRC Press, Boca Raton (2005). |
| | |
| 著者・発表者 | T. Imanishi and S. Obika |
| 表題 | Sugar-Modified Nucleic Acid Analogues as Potential Materials for Genomic Technologies |
| 発表先 | "Frontiers in Organic Chemistry," Atta-ur-Rahman Ed., pp 209-228, Bentham Science Publishers (2005). |
| | |
| 著者・発表者 | S. M. Abdur Rahman, Sayori Seki, Kazushige Utsuki, Satoshi Obika, Kazuyuki Miyashita and Takeshi Imanishi |
| 表題 | High-affinity RNA mimicking binding of 2',4'-BNANC towards complementary strands: A comparative study with 2',4'-BNA/LNA |
| 発表先 | Nucleic Acids Symp. Ser., 50, 195-196 (2006) |
| | |
| 著者・発表者 | Shiho Fujii, Satoshi Obika and Takeshi Imanishi |
| 表題 | Effects of the 2',4'-BNA modification on the sequence specificity of molecular beacons |
| 発表先 | Nucleic Acids Symp. Ser. 49, 211-212 (2005). |
| | |
| 著者・発表者 | Sachiko Matsugu, Hiroyasu Inohara, Satoshi Obika and Takeshi Imanishi |
| 表題 | Synthesis and triplex-forming properties of 2',4'-BNA derivatives bearing pyridines as an unnatural nucleobase |
| 発表先 | Nucleic Acids Symp. Ser. 49, 159-160 (2005). |
| | |
| 著者・発表者 | Masaharu Tomizu, Osamu Nakagawa, Satoshi Obika and Takeshi Imanishi |
| 表題 | Promotion of acid-mediated cleavage of oligonucleotide P3'N5' phosphoroamidates by triplex formation : A novel approach to sequence-specific DNA detection |
| 発表先 | Nucleic Acids Symp. Ser. 49, 157-158 (2005). |
| | |
| 著者・発表者 | S. M. Abdur Rahman, Sayori Seki, Kazushige Utsuki, Satoshi Obika, Kazuyuki Miyashita and Takeshi Imanishi |
| 表題 | Synthesis and properties of 2',4'-BNANC, a second generation BNA |
| 発表先 | Nucleic Acids Symp. Ser. 49, 5-6 (2005). |
| | |
| 著者・発表者 | S. M. Abdur Rahman, Sayori Seki, Kazushige Utsuki, Satoshi Obika, Kazuyuki Miyashita and Takeshi Imanishi |
| 表題 | High-affinity RNA mimicking binding of 2',4'-BNANC towards complementary strands: A comparative study with 2',4'-BNA/LNA |
| 発表先 |
第33回核酸化学シンポジウム |
| | |
| 著者・発表者 | Shiho Fujii, Satoshi Obika and Takeshi Imanishi |
| 表題 | Effects of the 2',4'-BNA modification on the sequence specificity of molecular beacons |
| 発表先 | 4th International Symposium on Nucleic Acids Chemistry |
| | |
| 著者・発表者 | Sachiko Matsugu, Hiroyasu Inohara, Satoshi Obika and Takeshi Imanishi |
| 表題 | Synthesis and triplex-forming properties of 2',4'-BNA derivatives bearing pyridines as an unnatural nucleobase |
| 発表先 | 4th International Symposium on Nucleic Acids Chemistry |
| | |
| 著者・発表者 | Masaharu Tomizu, Osamu Nakagawa, Satoshi Obika and Takeshi Imanishi |
| 表題 | Promotion of acid-mediated cleavage of oligonucleotide P3'N5' phosphoroamidates by triplex formation : A novel approach to sequence-specific DNA detection |
| 発表先 | 4th International Symposium on Nucleic Acids Chemistry |
| | |
| 著者・発表者 | S. M. Abdur Rahman, Sayori Seki, Kazushige Utsuki, Satoshi Obika, Kazuyuki Miyashita and Takeshi Imanishi |
| 表題 | Synthesis and properties of 2',4'-BNANC, a second generation BNA |
| 発表先 | 4th International Symposium on Nucleic Acids Chemistry |
| | |
| 著者・発表者 | S. M. Abdur Rahman, Sayori Seki, Satoshi Obika, Haruhisa Yoshikawa, Kazuyuki Miyashita and Takeshi Imanishi |
| 表題 | Design, Synthesis and Properties of 2’,4’-BNANC: A Bridged Nucleic Acid Analogue |
| 発表先 | J. Am. Chem. Soc., 130, 4886-4896 (2008). |
| | |
| 著者・発表者 | 小比賀 聡、戸水 真治、根来 佳憲、細木 教世、折田 文子、尾崎 朋久、今西 武 |
| 表題 | 迅速簡便な遺伝子検出を目指した機能性人工核酸5'-amino-BNA類の開発 |
| 発表先 |
第33回反応と合成の進歩シンポジウム |
| | |
| 著者・発表者 | 小比賀 聡 |
| 表題 | 遺伝子の発現制御と解析に向けた機能性人工核酸BNAの開発 |
| 発表先 |
日本薬学会第128年会  |
| | |
| 著者・発表者 | 小比賀 聡 |
| 表題 | 架橋型人工核酸BNAの開発とその応用 |
| 発表先 |
第10回生命化学研究会シンポジウム・熊本（2008） |
| | |
| 著者・発表者 | 小比賀 聡 |
| 表題 |
迅速簡便なSNP検出法の開発 - DNA三重らせんの利用 - |
| 発表先 |
第8回地域研究交流フォーラム |
| | |
| 著者・発表者 | K. Miyashita, S. M. A. Rahman, S. Seki, S. Obika, T. Imanishi |
| 表題 | N-Methyl substituted 2’,4’-BNANC: A highly nuclease-resistance nucleic acid analogue with high-affinity RNA selective hybridization |
| 発表先 |
Chem. Commun., 2007,3765-3767 |
| | |
| 著者・発表者 | 小比賀 聡, 戸水 真治, 根来 佳憲, 今西 武 |
| 表題 | 三重鎖核酸形成を基盤とする革新的DNA分析 |
| 発表先 | 日本薬学会第127年会（富山） |
| | |
| 著者・発表者 | 小比賀 聡、戸水 真治、根来 佳憲、折田 文子、尾崎 朋久、今西 武 |
| 表題 | 三重鎖形成核酸を利用した迅速・簡便なSNP検出 |
| 発表先 |
日本ケミカルバイオロジー研究会第2回年会（京都） |
| | |
| 著者・発表者 | T. Osaki, S. Obika, Y. Harada, Y. Mitsuoka, K. Sugaya, M. Sekiguchi, T. Imanishi |
| 表題 | Development of a novel nucleoside analogue with S-type sugar conformation: 2'-Deoxy-trans-3',4'-bridged nucleic acid |
| 発表先 | Tetrahedron, 63, 8977-8986 (2007) |
| | |
| 著者・発表者 | S. M. A. Rahman, S. Seki, S. Obika, K. Miyashita, T. Imanishi |
| 表題 | Highly stable pyrimidine-motif triplex formation at physiological pH values by a bridged nucleic acid analogue |
| 発表先 | Angew. Chem. Int. Ed., 46, 4306-4309 (2007) |
| | |
| 著者・発表者 | S. Obika, M. Tomizu, Y. Negoro, T. Osaki, A. Orita, Y. Ueyama, O. Nakagawa, T. Imanishi |
| 表題 |
Acid-mediated cleavage of oligonucleotide P3’・N5’ phosphoramidates triggered by sequence-specific triplex formation |
| 発表先 | Nucleosides, Nucleotides and Nucleic Acids, 26, 893-896 (2007) |
| | |
| 著者・発表者 | S. M. A. Rahman, S. Seki, K. Utsuki, S. Obika, K. Miyashita, T. Imanishi |
| 表題 | 2’,4’-BNANC: A novel bridged nucleic acid analogue with excellent hybridizing and nuclease resistance profiles |
| 発表先 | Nucleosides, Nucleotides and Nucleic Acids, 26, 1625-1628 (2007) |
| | |
| 著者・発表者 | T. Osaki, S. Obika, Y. Harada, Y. Mitsuoka, K. Sugaya, M. Sekiguchi, R. Somjing, T. Imanishi |
| 表題 | Synthesis of novel 2’-deoxy type trans-3’,4’-bridged nucleic acid |
| 発表先 | Nucleosides, Nucleotides and Nucleic Acids, 26, 1079-1082 (2007) |
| | |
| 著者・発表者 | S. Obika, M. Tomizu, Y. Negoro, T. Osaki, A. Orita, Y. Ueyama, O. Nakagawa, T. Imanishi |
| 表題 | Acid-mediated cleavage of oligonucleotide P3’->N5’ phosphoramidates triggered by sequence specific triplex formation |
| 発表先 | XVII International Roundtable on Nucleosides, Nucleotides and Nucleic Acids (Bern) |
| | |
| 著者・発表者 | 小比賀 聡, 戸水 真治, 根来 佳憲, 今西 武 |
| 表題 | 三重鎖核酸形成を基盤とする革新的ＤＮＡ分析 |
| 発表先 |
日本ケミカルバイオロジー研究会第1回年会（東京） |
| | |
| 著者・発表者 | S. Obika, M. Tomizu, Y. Negoro, A. Orita, O. Nakagawa, T. Imanishi |
| 表題 | Double-stranded DNA-templated oligonucleotide digestion triggered by triplex formation |
| 発表先 | ChemBioChem, 8, 1924-1928 (2007) |
| | |
| 著者・発表者 | M. Sekiguchi, S. Obika, Y. Harada, T. Osaki, R. Somjing, Y. Mitsuoka, N. Shibata, M. Masaki, T. Imanishi |
| 表題 | Synthesis and properties of trans-3',4'-bridged nucleic acids having typical S-type sugar conformation |
| 発表先 | J. Org. Chem., 71, 1306-1316 (2006) |
| | |
| 著者・発表者 | S. Obika, H. Inohara, Y. Hari, T. Imanishi |
| 表題 | Recognition of T・A interruption by 2’,4’-BNAs bearing heteroaromatic nucleobases through parallel motif triplex formation |
| 発表先 | Bioorg. Med. Chem., 16, 2945-2954 (2008). |
| | |
| 著者・発表者 | Y. Hari, S. Obika, H. Inohara, M. Ikejiri, D. Une, T. Imanishi |
| 表題 | Synthesis and triplex-forming ability of 2',4'-BNAs bearing imidazoles as a nucleobase |
| 発表先 | Chem. Pharm. Bull., 53, 843-846 (2005). |
| | |
| 著者・発表者 | Y. Hari, S. Obika, R. Ohnishi, K. Eguchi, T. Osaki, H. Ohishi, T. Imanishi |
| 表題 | Synthesis and properties of 2'-O,4'-C-methyleneoxymethylene bridged nucleic acid |
| 発表先 | Bioorg. Med. Chem., 14, 1029-1038 (2006) |
| | |
| 著者・発表者 | S. Y. Reddy, S. Obika, T. C. Bruice |
| 表題 | Conformations and dynamics of Ets-1 ETS domain-DNA complexes |
| 発表先 | Proc. Natl. Acad. Sci. USA, 100, 15475-15480 (2003) |
| | |
| 著者・発表者 | S. Obika, S. Y. Reddy, T. C. Bruice |
| 表題 | Sequence specific DNA binding of Ets-1 transcription factor: Molecular dynamics study on the ETS domain-DNA complexes |
| 発表先 | J. Mol. Biol., 331, 345-359 (2003) |
| | |
| 著者・発表者 | S. Obika, O. Nakagawa, A. Hiroto, Y. Hari, T. Imanishi |
| 表題 | Synthesis and properties of a novel bridged nucleic acid with a P3'->N5' phosphoramidate linkage, 5'-amino-2',4'-BNA |
| 発表先 | Chem. Commun., 2202-2203 (2003) |
| | |
| 著者・発表者 | S. Obika |
| 表題 | Development of bridged nucleic acid analogues for antigene technology |
| 発表先 | Chem. Pharm. Bull., 52, 1399-1404 (2004) |
| | |
| 著者・発表者 | S. Obika, M. Sekiguchi, R. Somjing,T. Imanishi |
| 表題 | Adjustment of the g dihedral angle of an oligonucleotide P3'->N5' phosphoramidate enhances its binding affinity towards complementary strands |
| 発表先 | Angew. Chem., Int. Ed., 44, 1944-1947 (2005) |
| | |
| 著者・発表者 | S. Obika, A. Hiroto, O. Nakagawa, T. Imanishi |
| 表題 | Promotion of stable triplex formation by partial incorporation of 2’,5’-phosphodiester linkages into triplex-forming oligonucleotides |
| 発表先 | Chem. Commun., 2793-2795 (2005). |
