New diagnostic and therapeutic tools targeting epigenetic modulation for lifestyle-related disease

Research Project Outline

Hemodialysis patients increases year by year and their main causes are diabetes and hypertension. Furthermore, deterioration of kidney function leads high mortality in cardiovascular diseases. It is the urgent issue to establish novel therapeutics to inhibit the progression of renal disease. In the present study, we aim to clarify the involvement of epigenomic abnormality in the diabetic nephropathy and hypertensive renal damage. Based upon the data obtained, we propose new diagnostic and therapeutic tools targeting epigenomic regulatory factors in lifestyle-related diseases.