Reference epigenome analysis in normal epithelial cells of human digestive system and development of analysis technology

Research Project Outline

The aim of this study is to reveal the reference epigenome profiles, the whole picture of mechanisms regulating gene expression, e.g. DNA methylation, chromatin modifications, positions of nucleosomes and variants, and abundance of each RNA species, of human normal cells and contribute to the International Human Epigenome Consortium.We are attempting to make international contributions by epigenome analysis in normal epithelial cells of the digestive system, e.g. the stomach, colon and liver, and development of innovative technologies. Reference epigenomedatabase will be accessible worldwide and promote the innovation of diagnosis and therapy of human diseases through the efficient identification of disease-specific epigenome profiles.