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Transportation of Viral RNP in Nucleus and Manipulation of Chromosome using Optical tweezers: Challenge to Remove Viral Genome from Host Cell Nucleus

Research Project Outline

After infl uenza virus infection, the viral genome RNA-viral RNA polymerase-NP complex (vRNP) is transported into nucleus, where transcription and replication of the viral genome takes place. Using the fl uorescein-labelled virus,vRNP and the optical tweezers, we will perform: i) virus infection on to a single cell for monitoring single virus growth; ii) transportation of vRNP in nucleus; and iii)measurement of the power for vRNP transportation. Our research will be extended for devel-opment ofa novel optical tweezers system to be used for manipulation of the chromosome and for removal ofthe viral genome from infected cell nuclei.

Research Director
Professor, Hosei University
Research Started
Research Area
Enhancing applications of innovative optical science and technologies by making ultimate use of advanced light sources
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