Basic information of the Research Area

[Cell Dynamics]Spatiotemporal Dynamics of Intracellular Components

Strategic Objective

Functional dynamics in the cell

Overview

This research area aims to gain an integrated understanding of the structure-function relationship of the cell by observing and measuring the dynamics in microspace of cellular higher-order structural components, from supramolecular complexes to organelles and membrane-less organelles, and analyzing their functional correlations.
In recent years, the development of observation and measurement techniques such as cryo-electron microscopy, super-resolution microscopy, and high-speed atomic force microscopy have greatly improved our understanding of intracellular microstructure and dynamics. This has led to a rapid increase in structural information on large membrane-protein complexes etc. and new phenomena, such as biological phase separation and inter-organelle contacts, which have led to a rethinking of the conventional concept of the cell. On the other hand, for an integrated understanding of the cell, it is necessary to promote bidirectional approaches by increasing the sizes of the targets for high-resolution structural analyses and in turn, by increasing the resolution of cellular imaging analyses, which allows us to obtain precise knowledge of the intracellular higher-order structural components and to integrate them.
In this research area, we aim to develop technologies for observation, measurement, and control of intracellular phenomena to overcome the above-mentioned issues, and to elucidate the functions of higher-order intracellular structural components by using these technologies, which will lead to advanced understanding of biological phenomena.

Research Area Advisors

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Schedule of Selection Process

Deadline for application	2022/06/07 at 12:00 noon, Japan time
Document-based review	2022/07/12
JST will contact to the interviewees no later than	2022/07/19
Interview-based review（※） ※Interview date and time will be assigned by JST.	2022/08/09

Research Supervisor's Policy

Research Supervisor's Policy of this Research Area can be downloaded from below.