原著論文

2017
"Synthetic Chromatin Acylation by an Artificial Catalyst System"

Ishiguro, T.; Amamoto, Y.; Tanabe, K.; Liu, J.; Kajino, H.; Fujimura, A.; Aoi, Y.; Osakabe, A.; Horikoshi, N.; Kurumizaka, H.; Yamatsugu, K.; Kawashima, S. A.; Kanai, M.
Chem 2017, 2, 840. DOI: 10.1016/j.chempr.2017.04.002



"Synthetic Posttranslational Modifications: Chemical Catalyst-Driven Regioselective Histone Acylation of Native Chromatin"

Amamoto, Y.; Aoi, Y; Nagashima, N.; Suto, H.; Yoshidome, D.; Arimura, Y.; Osakabe, A.; Kato, D.; Kurumizaka, H.; Kawashima, S. A.; Yamatsugu, K.; Kanai, M.
J. Am. Chem. Soc. 2017, 139, 7568. DOI: 10.1021/jacs.7b02138



"Ligand-Free, Copper-Catalyzed Aerobic Benzylic sp3 C-H Oxygenation"

Tanaka, H.; Oisaki, K.; Kanai, M.
Synlett 2017,28 ASAP DOI: 10.1055/s-0036-1588969



"Copper(I)-Catalyzed Enantioselective Addition of Enynes to Ketones"

Wei, X.-F.; Xie, X.-W.; Shimizu, Y.; Kanai, M.
J. Am. Chem. Soc. 2017,139 4647. DOI: 10.1021/jacs.7b01254



"Silver-Catalyzed C(sp3)-H Chlorination"

Ozawa, J.; Kanai, M.
Org. Lett 2017, 19 , 1430. DOI: 10.1021/acs.orglett.7b00367



"Hybrid Catalysis Enabling Room-Temperature Hydrogen Gas Release from N-Heterocycles and Tetrahydronaphthalenes"

Kato, S.; Saga, Y.; Kojima, M.; Fuse, H.; Matsunaga, S.; Fukatsu, A.; Kondo, M.; Masaoka, S.; Kanai, M.
J. Am. Chem. Soc. 2017, 139 , 2204. DOI: 10.1021/jacs.7b00253



"Scandium(III) triflate-promoted serine/threonine selectivepeptide bond cleavage"

Ni, J.; Sohma, Y.; Kanai, M.
Chem. Commun. 2017, 53 , 3311. DOI: 10.1039/C6CC10300F



"Lewis Acid-Base Interaction-Controlled ortho-Selective C-H Borylation of Aryl Sulfides"

Li, H. L.; Kuninobu, Y.; Kanai, M.
Angew. Chem. Int. Ed. 2017, 56 , 1495. DOI: 10.1002/anie.201610041


2016
"Copper(I)-Catalyzed Dehydrative C-Glycosidation of Unprotected Pyranoses with Ketones"

Wei, X.-F.; Shi, S.-L.; Xie, X.-W.; Shimizu, Y.; Kanai, M.
ACS Catal. 2016, 6 , 6718. DOI: 10.1021/acscatal.6b02106


"Transition Metal-Free, Tryptophan-Selective Bioconjugation of Proteins"

Seki, Y.; Ishiyama, T.; Sasaki, D.; Abe, J.; Sohma, Y.; Oisaki, K.; Kanai, M.
J. Am. Chem. Soc. 2016, 138 , 10798. DOI: 10.1021/jacs.6b06692


"5-Position-selective C-H trifluoromethylation of 8-aminoquinoline derivatives"

Kuninobu, Y.; Nishi, M.; Kanai, M.
Org. Biomol. Chem. 2016, 14 , 8092. DOI: 10.1039/C6OB01325B


"Enhanced Structural Variety of Nonplanar N-Oxyl Radical Catalysts and Their Application to the Aerobic Oxidation of Benzylic C-H Bonds"

Kadoh, Y.; Oisaki, K.; Kanai, M.
Chem. Pharm. Bull. 2016, 64 , 737. DOI: 10.1248/cpb.c16-00083


"Switchable Photooxygenation Catalysts that Sense Higher-Order Amyloid Structures"

Taniguchi, A.; Shimizu, Y.; Oisaki, K.; Sohma, Y.; Kanai, M.
Nat. Chem. 2016, 8 , 974. DOI: 10.1038/nchem.2550


"4-Position-Selective C-H Perfluoroalkylation and Perfluoroarylation of Six-Membered Heteroaromatic Compounds"

Nagase, M.; Kuninobu, Y.; Kanai, M.
J. Am. Chem. Soc. 2016, 138, 6103. DOI: 10.1021/jacs.6b01753


"Directing activator-assisted regio- and oxidation state-selective aerobic oxidation of secondary C(sp3)-H bonds in aliphatic alcohols"

Ni, J.; Ozawa, J.; Oisaki, K.; Kanai, M.
Org. Biomol. Chem. 2016, 14, 4378. DOI: 10.1039/C6OB00678G


"An Expeditious Synthesis of Sialic Acid Derivatives by Copper(I)-Catalyzed Stereodivergent Propargylation of Unprotected Aldoses"

Wei, X.-F.; Shimizu, Y.; Kanai, M.
ACS Cent.Sci. 2016, 2, 21. DOI: 10.1021/acscentsci.5b00360


"Chemo- and Regioselective Oxygenation of C(sp3)-H Bonds in Aliphatic Alcohols Using a Covalently Bound Directing Activator and Atmospheric Oxygen"

Ozawa, J.; Tashiro, M.; Ni, J.; Oisaki, K.; Kanai, M.
Chem.Sci. 2016, 7, 1904. DOI: 10.1039/C5SC04476F


2015
"Catalytic Asymmetric Iterative/Domino Aldehyde Cross-Aldol Reactions for the Rapid and Flexible Synthesis of 1,3-Polyols"

Lin, L.; Yamamoto, K.; Mitsunuma, H.; Kanzaki, Y.; Matsunaga, S.; Kanai, M.
J. Am. Chem. Soc. 2015, 137, 15418. DOI: 10.1021/jacs.5b11192


"Supramolecular Ligands for Histone Tails by Employing a Multivalent Display of Trisulfonated Calix[4]arenes"

Kimura, Y.; Saito, N.; Hanada, K.; Liu, J.; Okabe, T.; Kawashima, S. A.; Yamatsugu, K.; Kanai, M.
ChemBioChem 2015, 16, 2599. DOI: 10.1002/cbic.201500448


"A meta-selective C-H Borylation Directed by a Secondary Interaction Between Ligand and Substrate"

Kuninobu, Y.; Ida, H.; Nishi, M.; Kanai, M.
Nat. Chem. 2015, 7, 712. DOI: 10.1038/nchem.2322
Selected as Nat. Chem. News & Views


"Benzylic C(sp3)-H Perfluoroalkylation of Six-Membered Heteroaromatic Compounds"

Kuninobu, Y.; Nagase, M.; Kanai, M.
Angew. Chem. Int. Ed. 2015, 54, 10263. DOI: 10.1002/anie.201505335


"Organocatalytic Aerobic Oxdation to α-Fluoroalkyl Alcohols to Fluoroalkyl Ketones at Room Temperature"

Kadoh, Y.; Tashiro, M.; Oisaki, K.; Kanai, M.
Adv. Synth. Catal. 2015, 357, 2193. DOI: 10.1002/adsc.201500131


"Synthesis of Chemically-tethered Amyloid-β Segment Trimer Possessing Amyloidogenic Properties"

Shinoda, K.; Sohma, Y.; Kanai, M.
Bioorg. Med. Chem. Lett. 2015, 25, 2976. DOI: 10.1016/j.bmcl.2015.05.029


"Covalent Modifier-type Aggregation Inhibitor of Amyloid-β Based on a cyclo-KLVFF Motif"

Kino, R.; Araya, T.; Arai, T.; Sohma, Y.; Kanai, M.
Bioorg. Med. Chem. Lett. 2015, 25, 2972. DOI: 10.1016/j.bmcl.2015.05.027


"Palladium-Catalyzed Oxirane-Opening Reaction with Arenes via C-H Bond Activation"

Wang, Z.; Kuninobu, Y.; Kanai, M.
J. Am. Chem. Soc. 2015, 137, 6140. DOI: 10.1021/jacs.5b02435


"Palladium-Catalyzed Construction of Heteroatom-Containing π-Conjugated Systems by Intramolecular Oxidative C-H/C-H Coupling Reaction"

Saito, K.; Chikkade, P. K.; Kanai, M.; Kuninobu, Y.
Chem. Eur. J. 2015, 21, 8365. DOI: 10.1002/chem.201501116


"Copper-Catalyzed Intermolecular C(sp3)-H Bond Functionalization Towards the Synthesis of Tertiary Carbamates"

Chikkade, P. K.; Kuninobu, Y.; Kanai, M.
Chem. Sci. 2015, 6, 3195. DOI: 10.1039/C5SC00238A


"Iridium-Catalyzed ortho-Selective C-H Silylation of Aromatic Compounds Directed toward the Synthesis of π-Conjugated Molecules with Lewis Acid-Base Interaction"

Wakaki, T.; Kanai, M.; Kuninobu, Y.
Org. Lett. 2015, 17, 1758. DOI: 10.1021/acs.orglett.5b00529


2014
"Molybdenum-mediated Desulfurization of Thiols and Disulfides"

Wang, Z.; Kuninobu, Y.; Kanai, M.
Synlett 2014, 25, 1869. DOI: 10.1055/s-0034-1378315


"A Cyclic KLVFF-Derived Peptide Aggregation Inhibitor Induces the Formation of Less-Toxic Off-Pathway Amyloid-β Oligomers"

Arai, T.; Sasaki, D.; Araya, T.; Sato, T.; Sohma, Y.; Kanai, M.
ChemBioChem 2014, 15, 2577. DOI: 10.1002/cbic.201402430


"Copper-Mediated Direct C(sp3)-H and C(sp2)-H Acetoxylation"

Wang, Z.; Kuninobu, Y.; Kanai, M.
Org. Lett. 2014, 16, 4790. DOI: 10.1021/ol5022542


"Rational Design and Identification of Non-Peptidic Aggregation Inhibitor of Amyloid-beta Based on a Pharmacophore Motif Obtained from cyclo[-Lys-Leu-Val-Phe-Phe-]"

Arai, T.; Araya, T.; Sasaki, D.; Taniguchi, A.; Sato, T.; Sohma, Y.; Kanai, M.
Angew. Chem. Int. Ed. 2014, 53, 1. DOI: 10.1002/anie.201405109
Selected as Hot Paper.


"Serine-Selective Aerobic Cleavage of Peptides and a Protein Using Water-Soluble Copper Organoradical Conjugate"

Seki, Y.; Tanabe, K.; Sasaki, D.; Sohma, Y.; Oisaki, K.; Kanai, M.
Angew. Chem. Int. Ed. 2014, 53, 6501. DOI: 10.1002/anie.201402618


"Palladium-Catalyzed Direct C–H Silylation and Germanylation of Benzamides and Carboxamides"

Kanyiva, K. S.; Kuninobu, Y.; Kanai, M.
Org. Lett. 2014, 16, 1968. DOI: 10.1021/ol500519y


"Regioselective Trifluoromethylation of N-Heteroaromatic Compounds using BF2CF3 Activator"

Nishida, T.; Ida, H.; Kuninobu, Y.; Kanai, M.
Nat. Commun. 2014, 5, 3387. DOI: 10.1038/ncomms4387
Selected by Nat.Commun. Chemistry Selections.


"Asparagine-Selective Cleavage of Peptide Bonds through Hypervalent Iodine-Mediated Hofmann Rearrangement in Neutral Aqueous Solution"

Tanabe, K.; Taniguchi, A.; Matsumoto, T.; Oisaki, K.; Sohma, Y.; Kanai, M.
Chem. Sci. 2014, 5, 2747. DOI: 10.1039/C3SC53037J
Most downloaded Article (2014/March) of Chem. Sci.


"Copper-Catalyzed Intermolecular C(sp3)-H and C(sp2)-H Amidation by Oxidative Cyclization"

Wang, Z.; Ni, J.; Kuninobu, Y.; Kanai, M.
Angew. Chem. Int. Ed. 2014, 53, 1. DOI: 10.1002/anie.201311105


"Copper-Catalyzed Benzylic C(sp3)-H Alkoxylation of Heterocyclic Compounds"

Takemura, N.; Kuninobu, Y.; Kanai, M.
Org. Biomol. Chem. 2014, 12, 2528. DOI: 10.1039/C4OB00215F


"Palladium-Catalyzed C-H Fluorosilylation of 2-Phenylpyridines: Synthesis of Silafluorene Equivalents"

Xiao, Q.; Meng, X.; Kanai, M.; Kuninobu, Y.
Angew. Chem. Int. Ed. 2014, 126, 3232. DOI: 10.1002/ange.201310293


"Synthesis of Pyridine N-Oxide-BF2CF3 Complexes and Their Fluorescence Properties"

Nishida, T.; Fukazawa, A.; Yamaguchi, E.; Oshima, H.; Yamaguchi, S.; Kanai, M.; Kuninobu, Y.
Chem. Asian J. 2014, 9, 1026. DOI: 10.1002/asia.201301688


"Catalytic Enantioselective Synthesis of 2-(2-hydroxyethyl)indole Scaffolds via Consecutive Intramolecular Amido-cupration of Allenes and Asymmetric Addition of Carbonyl Compounds"

Chikkade, P. K.; Shimizu, Y.; Kanai, M.
Chem. Sci. 2014, 5, 1585. DOI: 10.1039/C3SC52803K


"A Catalytic C-C Bond-Formation with Minimal Use of Protecting Groups: Construction of Functionalized Isotetronic Acid Derivatives"

Shimizu, Y.; Yasuda, K.; Kanai, M.
Heterocycles 2014, 88, 919. DOI: DOI: 10.3987/COM-13-S(S)81


"Attenuation of the Aggregation and Neurotoxicity of Amyloid-β Peptides by Catalytic Photooxygenation"

Taniguchi, A.; Sasaki, D.; Shiohara, A.; Iwatsubo, T.; Tomita, T.; Sohma, Y.; Kanai, M.
Angew. Chem. Int. Ed. 2014, 53, 1382. DOI: 10.1002/anie.201308001
Selected as Hot Paper.


2013
"Rh-Catalyzed Aldehyde-Aldehyde Cross-Aldol Reaction under Base-Free Conditions: In Situ Aldehyde-Derived Enolate Formation through Orthogonal Activation"

Lin, L; Yamamoto, K.; Matsunaga, S.; Kanai, M.
Chem. Asian J. 2013, 8, 2974. DOI: 10.1002/asia.201300928


"Copper-Catalyzed Intramolecular N–S Bond Formation by Oxidative Dehydrogenative Cyclization"

Wang, Z.; Kuninobu, Y.; Kanai, M.
J. Org. Chem. 2013, 78, 7337. DOI: 10.1021/jo401056g


"In situ Catalytic Generation of Allylcopper Species for Asymmetric Allylation: Toward 1H-Isochromene Skeletons"

Kawai, J.; Chikkade, P. K.; Shimizu, Y.; Kanai, M.
Angew. Chem. Int. Ed. 2013, 52, 7177. DOI: 10.1002/anie.201302027


"Intracellular Activation of Acetyl-CoA by an Artificial Reaction Promoter and Its Fluorescent Detection"

Komatsu, H.; Shindo, Y.; Kawashima, S. A.; Yamatsugu, K.; Oka, K.; Kanai, M.
Chem. Commun. 2013, 49, 2876. DOI: 10.1039/C3CC40616D


"Cobalt-Catalyzed C4-Selective Direct Alkylation of Pyridines"

Andou, T.; Saga, Y.; Komai, H.; Matsunaga, S. Kanai, M.
Angew. Chem. Int. Ed. 2013, 52, 3213. DOI: 10.1002/anie.201208666


"Copper-Catalyzed C-H Alkoxylation of Azoles"

Takemura, N.; Kuninobu, Y. Kanai, M.
Org. Lett. 2013, 15, 844. DOI: 10.1021/ol303533z


"A Cationic High-Valent Cp*CoIII Complex for the Catalytic Generation of Nucleophilic Organometallic Species: Directed C-H Bond Activation"

Yoshino, T. Ikemoto, H.; Matsunaga, S.; Kanai, M.
Angew. Chem. Int. Ed.2013, 52,2207. DOI: 10.1002/anie.201209226


2012
"Copper(I)-Catalyzed Enantioselective Incorporation of Ketones to Cyclic Hemiaminals for the Synthesis of Versatile Alkaloid Precursors"

Shi, S.-L.; Wei, X.-F.; Shimizu, Y.; Kanai, M.
J. Am. Chem. Soc. 2012, 134, 17019. DOI: 10.1021/ja308872z


"Rhodium-Catalyzed Cross-Aldol Reaction: In Situ Aldehyde-Enolate Formation from Allyloxyboranes and Primary Allylic Alcohols"

Lin, L.; Yamamoto, K.; Matsunaga, S.; Kanai, M.
Angew. Chem. Int. Ed. 2012, 51, 10275. DOI: 10.1002/anie.201205680


"Catalytic Aerobic Production of Imines en Route to Mild, Green, and Concise Derivatizations of Amines"

Sonobe, T.: Oisaki, K.; Kanai, M.
Chem. Sci. 2012, 3, 3249. DOI: 10.1039/C2SC20699D


"Synthesis of a New Oseltamivir Derivative Through Late-Stage Catalytic C-H Functionalization"

Saito, K.; Kanai, M.
Heterocycles 2012, 86, 1565. DOI:10.3987/COM-12-S(N)94


"Functional Group-Tolerant Catalytic Migratory Oxidative Coupling of Nitrones"

Hashizume, S.: Oisaki, K.; Kanai, M.
Chem. Asian J. 2012, 7, 2600. DOI: 10.1002/asia.201200359


"Cu(I)-Catalyzed α-Alkylation of Ketones with Styrene Derivatives"

Majima, S.; Shimizu, Y.; Kanai, M.
Tetrahedron Lett. 2012, 53, 4381. DOI:10.1016/j.tetlet.2012.06.019

"Catalytic Asymmetric Synthesis of Spirooxindoles by a Mannich-Type Reaction of Isothiocyanato Oxindoles"

Kato, S.; Yoshino, T.; Shibasaki, M..; Kanai, M.; Matsunaga, S.
Angew. Chem. Int. Ed. 2012, 18, 7654. DOI: 10.1002/anie.201203005

"Lewis Acid Catalyzed Benzylic C-H Bond Functionalization of Azaarenes; Addition to Imines and Enones"

Komai, H.; Yoshino, T.; Matsunaga, S.; Kanai, M.
Synthesis 2012, 44, 2185. doi:10.1055/s-0031-1291041

"Mg-catalyzed Enantioselective Benzylic C-H Bond Functionalization of Isoindolinones: Addition to Imines"

Suzuki, Y.; Kanai, M.; Matsunaga, S.
Chem. Eur. J. 2012, 18, 7654. DOI: 10.1002/chem.201200821

"Catalytic Asymmetric Total Synthesis of Chimonanthine, Folicanthine, and Calycanthine through Double Michael Reaction of Bisoxindole"

Mitsunuma, H.; Shibasaki, M.; Kanai, M.; Matsunaga, S.
Angew. Chem. Int. Ed. 2012, 51, 5217. doi:10.1002/anie.201201132

"Asymmetric Synthesis of Dihydropyranones from Ynones by Sequential Copper(I)-Catalyzed Direct Aldol and Silver(I)-Catalyzed Oxy-Michael Reactions"

Shi, S.-L.; Kanai, M.; Shibasaki, M.
Angew. Chem. Int. Ed. 2012, 51, 3932. DOI: 10.1002/anie.201109209

解説論文・総説・著書

2012

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