ERATO 浜地ニューロ分子技術プロジェクト
Original Paper
2024年
- Profiling Proteins Involved in Peroxynitrite Homeostasis Using ROS/RNS Conditional Proteomics
Hao Zhu, Hiroaki Uno, Kyoichi Matsuba and Itaru Hamachi
Journal of the American Chemical Society, 2025, 147, 7305-7316.
doi: 10.1021/jacs.4c14060
- Photoproximity labeling of endogenous receptors in the live mouse brain in minutes
Mikiko Takato, Seiji Sakamoto, Hiroshi Nonaka, Fátima Yuri Tanimura Valor, Tomonori Tamura and Itaru Hamachi
Nature Chemical Biology, 2024, in press.
https://www.nature.com/articles/s41589-024-01692-4
- Kainate receptors regulate synaptic integrity and plasticity by forming a complex with synaptic organizers in the cerebellum
Wataru Kakegawa, Ana V. Paternain, Keiko Matsuda, M. Isabel Aller, Izumi Iida, Eriko Miura, Kazuya Nozawa, Tokiwa Yamasaki, Kenji Sakimura, Michisuke Yuzaki and Juan Lerma
Cell Reports, 2024, 114427.
https://doi.org/10.1016/j.celrep.2024.114427
- Protein-Labeling Reagents Selectively Activated by Copper(I)
Rong Cheng, Yuki Nishikawa, Takumi Wagatsuma, Taiho Kambe, Yu-ki Tanaka, Yasumitsu Ogra, Tomonori Tamura and Itaru Hamachi
ACS Chemical Biology, 2024, 19, 1222-1228.
doi: 10.1021/acschembio.4c00011
- Post-click labeling enables highly accurate single cell analyses of glucose uptake ex vivo and in vivo
Masaki Tsuchiya, Nobuhiko Tachibana and Itaru Hamachi
Communications Biology, 2024, 7, 459.
doi: 10.1038/s42003-024-06164-y
- Hijacking endogenous mRNA for genetic code expansion
Tomohiro Doura, Yuma Matsuoka and Shigeki Kiyonaka
nature chemical biology, 2024, 20, 660–661.
https://doi.org/10.1038/s41589-024-01574-9
- Crystal structure reveals the binding mode and selectivity of a photoswitchable ligand for the adenosine A2A receptor
Tsuyoshi Araya, Yuya Matsuba, Harufumi Suzuki, Tomohiro Doura, Nipawan Nuemket, Eriko Nango, Masaki Yamamoto, Dohyun Im, Hidetsugu Asada, Shigeki Kiyonaka and So Iwata
Biochemical and Biophysical Research Communications, 2024, 695, 149393.
https://doi.org/10.1016/j.bbrc.2023.149393
- Tyrosinase-BasedProximityLabelingin LivingCells andIn Vivo
Hao Zhu, Jae Hoon Oh, Yuna Matsuda, Takeharu Mino, Mamoru Ishikawa, Hideki Nakamura, Muneo Tsujikawa, Hiroshi Nonaka and Itaru Hamachi
Journalof the American Chemical Society, 2024, 146, 11, 7515-7523.
https://doi.org/10.1021/jacs.3c13183
- Emergenceof DynamicInstabilityby HybridizingSyntheticSelf-AssembledDipeptideFiberswithSurfactantMicelles
Shogo Torigoe, Kazutoshi Nagao, Ryou Kubota and Itaru Hamachi
Journalof the American Chemical Society, 2024, 146, 9, 5799–5805.
https://doi.org/10.1021/jacs.3c14565
- Bioorthogonal chemical labeling of endogenous neurotransmitter receptors in living mouse brains
Hiroshi Nonaka, Seiji Sakamoto, Kazuki Shiraiwa, Mamoru Ishikawa, Tomonori Tamura, Kyohei Okuno, Shigeki Kiyonaka, Etsuo A. Susaki, Chika Shimizu, Hiroki R. Ueda, Wataru Kakegawa, Itaru Arai, Michisuke Yuzaki and Itaru Hamachi
Proceedings of the National Academy of Sciences of the United States of America, 2024, 121, 6, 2313887121.
https://doi.org/10.1073/pnas.2313887121
2023
- Lysine-Reactive N-Acyl-N-aryl Sulfonamide Warheads: Improved Reaction Properties and Application in the Covalent Inhibition of an Ibrutinib-Resistant BTK Mutant
Masaharu Kawano, Syunsuke Murakawa, Kenji Higashiguchi, Kenji Matsuda, Tomonori Tamura and Itaru Hamachi
Journal of the American Chemical Society, 2023, 145, 48, 26202-26212.
https://doi.org/10.1021/jacs.3c08740
- Visualizing Formation and Dynamics of a Three-Dimensional Sponge-like Network of a Coacervate in Real Time
Ryou Kubota, Taro Hiroi, Yuriki Ikuta, Yuchong Liu and Itaru Hamachi
Journal of the American Chemical Society, 2023, 145, 33, 18316-18328.
doi:10.1021/jacs.3c03793
- Endogenous Cell-Surface Receptor Modification by Metal Chelation-Assisted Pyridinium Oxime Catalyst
Vikram Thimaradka, Hayata Utsunomiya, Tomonori Tamura and Itaru Hamachi
Organic Letters, 2023, 25, 12, 2118–2122.
https://doi.org/10.1021/acs.orglett.3c00541
- Four distinct network patterns of supramolecular/polymer composite hydrogels controlled by formation kinetics and interfiber interactions
Keisuke Nakamura, Ryou Kubota, Takuma Aoyama, Kenji Urayama and Itaru Hamachi
Nature Communications, 2023, 14, 1696.
https://doi.org/10.1038/s41467-023-37412-0
- Organelle-selective click labeling coupled with flow cytometry allows
pooled CRISPR screening of genes involved in phosphatidylcholine metabolism
Masaki Tsuchiya, Nobuhiko Tachibana, Nagao Kohjiro, Tomonori Tamura and
Itaru Hamachi
Cell Metabolism, 2023, 35, 1–12.
https://doi.org/10.1016/j.cmet.2023.02.014
2022
- In vivo nanoscopic landscape of neurexin ligands underlying anterograde
synapse specification
Kazuya Nozawa, Taku Sogabe, Ayumi Hayashi, Junko Motohashi, Eriko Miura,
Itaru Arai and Michisuke Yuzaki
Neuron, 2022, 110, 3168–3185. https://doi.org/10.1016/j.neuron.2022.07.027
- Revisiting PFA-mediated tissue fixation chemistry: FixEL enables trapping of small molecules in the brain to visualize their distribution changes
Hiroshi Nonaka, Takeharu Mino, Seiji Sakamoto, Jae Hoon Oh, Yu Watanabe, Mamoru Ishikawa, Akihiro Tsushima, Kazuma Amaike, Shigeki Kiyonaka, Tomonori Tamura, A. Radu Aricescu, Wataru Kakegawa, Eriko Miura, Michisuke Yuzaki and Itaru Hamachi
Chem 9, 523–540, 2023.
doi:10.1016/j.chempr.2022.11.005
- Temporal Stimulus Patterns Drive Differentiation of a Synthetic Dipeptide-Based Coacervate
Ryou Kubota, Shogo Torigoe and Itaru Hamachi
Journal of the American Chemical Society, 2022, 144, 33, 15155–15164.
doi: 10.1021/jacs.2c05101
- Coordination chemogenetics for activation of GPCR-type glutamate
receptors in brain tissue
Kento Ojima, Wataru Kakegawa, Tokiwa Yamasaki, Yuta Miura, Masayuki
Itoh, Yukiko Michibata, Ryou Kubota, Tomohiro Doura, Eriko Miura,
Hiroshi Nonaka, Seiya Mizuno, Satoru Takahashi, Michisuke Yuzaki, Itaru
Hamachi and Shigeki Kiyonaka
Nature Communications, 2022, 13, 3167. doi: 10.1038/s41467-022-30828-0
2021
- Orthogonal Activation of Metabotropic Glutamate Receptor Using
Coordination Chemogenetics
Akinobu Senoo, Yutaro Yamada, Kento Ojima, Tomohiro Doura, Itaru Hamachi and Shigeki Kiyonaka
Front Chem., 2021, 9, 825669-. https://doi.org/10.3389/fchem.2021.825669
- Phototriggered Spatially Controlled Out-of-Equilibrium Patterns of Peptide Nanofibers in a Self-Sorting Double Network Hydrogel
Keisuke Nakamura, Wataru Tanaka, Kei Sada, Ryou Kubota, Takuma Aoyama, Kenji Urayama and Itaru Hamachi
J. Am. Chem. Soc., 2021, 143, 19532-19541. https://doi.org/10.1021/jacs.1c09172
- Enhanced Suppression of a Protein-Protein Interaction in Cells Using Small-Molecule Covalent Inhibitors Based on an N‑Acyl‑N‑alkyl Sulfonamide Warhead
Tsuyoshi Ueda, Tomonori Tamura, Masaharu Kawano, Keiya Shiono, Fruzsina Hobor, Andrew J. Wilson and Itaru Hamachi
J. Am. Chem. Soc., 2021, 143, 4766-4774. https://doi.org/10.1021/jacs.1c00703
- Site-specific covalent labeling of His-tag fused proteins with N-acyl-N-alkyl sulfonamide reagent
Vikram Thimaradka, Jae Hoon Oh, Christina Heroven, A. Radu Aricescu, Michisuke Yuzaki, Tomonori Tamura and Itaru Hamachi
Bioorganic & Medicinal Chemistry, 2021, 30, 115947. doi:10.1016/j.bmc.2020.115947
- Ligand-directed two-step labeling to quantify neuronal glutamate receptor trafficking
Kento Ojima, Kazuki Shiraiwa, Tomohiro Doura, Mikiko Takato, Kazuhiro Komatsu, Michisuke Yuzaki, Itaru Hamachi and Shigeki Kiyonaka
Nature Communications, 2021, 12, 831. doi:10.1038/s41467-021-21082-x
2020
- In Situ Real-time Confocal Imaging of a Self-assembling Peptide-grafted Polymer Showing pH-responsive Hydrogelation
Ryou Kubota, Shogo Torigoe, Shuang Liu and Itaru Hamachi
Chemistry Letters, 2020, 49, 11, 1319-1323. doi:10.1246/cl.200513
- Organelle membrane-specific chemical labeling and dynamic imaging in living cells
Tomonori Tamura, Alma Fujisawa, Masaki Tsuchiya, Yuying Shen, Kohjiro Nagao, Shin Kawano, Yasushi Tamura, Toshiya Endo, Masato Umeda and Itaru Hamachi
Nature Chemical Biology, 2020, 16, 12, 1361-1367. doi:10.1038/s41589-020-00651-z
- A synthetic synaptic organizer protein restores glutamatergic neuronal circuits
Kunimichi Suzuki, Jonathan Elegheert, Inseon Song, Hiroyuki Sasakura, Oleg Senkov, Keiko Matsuda, Wataru Kakegawa, Amber J. Clayton, Veronica T. Chang, Maura Ferrer-Ferrer, Eriko Miura, Rahul Kaushik, Masashi Ikeno, Yuki Morioka, Yuka Takeuchi, Tatsuya Shimada, Shintaro Otsuka, Stoyan Stoyanov, Masahiko Watanabe, Kosei Takeuchi, Alexander Dityatev, A. Radu Aricescu and Michisuke Yuzaki
Science, 2020, 369, 6507, 1074-1093. doi:10.1126/science.abb4853
- Imaging and profiling of proteins under oxidative conditions in cells and tissues by hydrogen-peroxide-responsive labeling
Hao Zhu, Tomonori Tamura, Alma Fujisawa, Yuki Nishikawa, Rong Cheng, Mikiko Takato and Itaru Hamachi
Journal of the American Chemical Society, 2020, 142, 37, 15711-15721. doi:10.1021/jacs.0c02547
- Control of seed formation allows two distinct self-sorting patterns of supramolecular nanofibers
Ryou Kubota, Kazutoshi Nagao, Wataru Tanaka, Ryotaro Matumura, Takuma Aoyama, Kenji Urayama and Itaru Hamachi
Nature Communications, 2020, 11, 1, 4100. doi:10.1038/s41467-020-17984-x
- Activity-Based Sensing with a Metal-Directed Acyl Imidazole Strategy Reveals Cell Type-Dependent Pools of Labile Brain Copper
Sumin Lee, Yik Sham Clive Chung, Pei Liu, Laura Craciun, Yuki Nishikawa, Kevin Bruemmer, Itaru Hamachi, Kaoru Saijo, Evan Miller and Christopher Chang
Journal of the American Chemical Society, 2020, 142, 35, 14993-15003. doi:10.1021/jacs.0c05727
- Protein-responsive protein release of supramolecular/polymer hydrogel composite integrating enzyme activation systems
Hajime Shigemitsu, Ryou Kubota, Keisuke Nakamura, Tomonobu Matsuzaki, Saori Minami, Takuma Aoyama, Kenji Urayama and Itaru Hamachi
Nature Communications, 2020, 11, 1, 3859. doi:10.1038/s41467-020-17698-0
- Force generation by a propagating wave of supramolecular nanofibers
Ryou Kubota, Masahiro Makuta, Ryo Suzuki, Masatoshi Ichikawa, Motomu Tanaka and Itaru Hamachi
Nature Communications, 2020, 11, 1, 3541. doi:10.1038/s41467-020-17394-z
- Development of a Photoactivatable Proximity Labeling Method for the Identification of Nuclear Proteins
Tomonori Tamura, Mikiko Takato, Keiya Shiono and Itaru Hamachi
Chemistry Letters, 2020, 49, 2, 145-148. doi:10.1246/cl.190804
- Development of a Cell-Based Ligand-Screening System for
Identifying Hsp90 Inhibitors
Tsuyoshi Ueda, Tomonori Tamura and Itaru Hamachi
Biochemistry, 2020, 59, 2, 179-182. doi:10.1021/acs.biochem.9b00781
2019
- Construction of a Fluorescent Screening System of Allosteric Modulators for the GABAA Receptor Using a Turn-On ProbeA receptor using turn-on probe
Seiji Sakamoto, Kei Yamaura, Tomohiro Numata, Fumio Harada, Kazuma Amaike, Ryuji Inoue, Shigeki Kiyonaka and Itaru Hamachi
ACS Cent. Sci., 2019, 5, 9, 1541-1553. doi/10.1021/acscentsci.9b00539
- Post-assembly Fabrication of a Functional Multicomponent Supramolecular Hydrogel
Based on a Self-Sorting Double Network
Wataru Tanaka, Hajime Shigemitsu, Takahiro Fujisaku, Ryou Kubota, Saori Minami, Kenji Urayama and Itaru Hamachi
J. Am. Chem. Soc., 2019, 141, 12, 4997-5004. doi:10.1021/jacs.9b00715
- Development of a Nitric Oxide-Responsive Labeling Reagent for Proteome Analysis of Live Cells
Yuki Nishikawa, Takayuki Miki, Masashi Awa, Keiko Kuwata, Tomonori Tamura and Itaru Hamachi
ACS Chem. Biol., 2019, 14, 3, 397-404. doi: 10.1021/acschembio.8b01021
- Chemistry for Covalent Modification of Endogenous/Native Proteins: From Test Tubes to Complex Biological Systems
Tomonori Tamura and Itaru Hamachi
J. Am. Chem. Soc., 2019, 141, 7, 2782-2799. doi: 10.1021/jacs.8b11747