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Japan Science and Technology Agency.

Creation of a novel technology towards diagnosis and treatment based un understanding of molecular pathogenesis of psychiatric and neurological disorders
Research Themes, Principle Investigators

Mizusawa Team

Researcher's name Hidehiro Mizusawa
Professor,Tokyo Medical and Dental University
Research Themes Development of diagnosis and treatment based on the molecular pathomechanism of Purkinje cell degeneration.


Cerebellar Purkinje cell(PC) impairment cause spinocerebellar ataxiass (SCAs) but there has been few treatments. In this research, we plan to elucidate pathologic pathways from RNA expression to individual disease onset as well as to establish a treatment strategy through development of animal models imitating genetic SCAs with PC degenaration, and omics and chemical biology techniques. We would finally like to create treatment methods and diagnostic markers which could be applicable to PC impairment and cerebellar ataxia in general.