The team led by the research director Kaoru Inokuchi, Professor at University of Toyama, reports neural circuit mechanism underlying the association of memories. The team trained mice to form two separate aversive memories, conditioned taste aversion (CTA) and auditory fear conditioning (AFC). The team then linked these two unrelated memories by repeated retrieval. The numbers of neurons activated by retrieval of CTA and AFC memories, denoted as overlapping neurons, increased in the amygdala. The team successfully disconnected the link between CTA and AFC memories by optically silencing the activity of overlapping neurons without affecting recall of individual memories.
Research Area “BIODYNAMICS”
Research Theme “Memory integration process based on cell assembly and neural circuit model”
“Overlapping memory trace indispensable for linking, but not recalling, individual memories”. Science, 355, 398-403, January 27, 2017, doi: 10.1126/science.aal2690
Kaoru Inokuchi, Ph.D.
Professor, Department of Biochemistry, Faculty of Medicine, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama
Department of Innovation Research, JST