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JST Press Release

September 29, 2016
Japan Science and Technology Agency (JST)
5-3, Yonbancho, Chiyoda-ku, Tokyo 102-8666

Auto-regulatory mechanism for the expression of Chtop, a key protein factor for
carcinogenesis of glioblastoma and developmental transition from fetal to adult hemoglobin.

The mechanism by which Chtop expression is controlled via an autoregulatory negative feedback loop has been established. The results provide a mechanism for maintaining the cellular level of Chtop by intron retention and nonsense-mediated decay of its own mRNA, which will facilitate the development of therapeutic reagents for the treatment of glioblastoma and severe anemia including β-thalassemias and sickle cell disease.

Program Information

Research Area “Structural Life Science and Advanced Core Technologies for Innovative Life Science Research”
Research Theme “Molecular studies of RNA-dysmetabolic syndrome From ribonucleoproteomics to structural life science ”

Journal Information

Keiichi Izumikawa, Harunori Yoshikawa, Hideaki Ishikawa, Yuko Nobe, Yoshio Yamauchi, Sjaak Philipsen, Richard J Simpson, Toshiaki Isobe, and Nobuhiro Takahashi. “Chtop (Chromatin target of Prmt1) auto-regulates its expression level via intron retention and nonsense-mediated decay of its own mRNA”. Nucleic Acids Research, the open-access journal of Oxford University Press, Published online 28 September 2016, doi: 10.1093/nar/gkw831.


[About Research]
Nobuhiro Takahashi, Ph.D.
Professor, Graduate School of Agriculture, Tokyo University of Agriculture & Technology
URL: http://old-www.tuat.ac.jp/en/index.html

[About Program]
Tetsu Kawaguchi
Life Innovation Group, Department of Innovation Research, JST


JST, an integrated organization of science and technology in Japan, establishes an infrastructure for the entire process from the creation of knowledge to the return to the society. For more information, visit http://www.jst.go.jp/EN/