Naruhiko Adachi

Degree

Ph.D.

Position, Research site

Assistant Professor, Structural Biology Research Center (SBRC), Institute of Materials Structure Science (IMSS), High Energy Accelerator Research Organization (KEK)

URL

http://www2.kek.jp/imss/sbrc/eng/

Research Field

Transcriptional regulation, Structural biology

• Education, Research career
• Publication
• Books,Patent,Award

Original Papers

1. Koentjoro, M.P., Adachi, N., Senda, M., Ogawa, N., and Senda, T.
   Crystal structure of the DNA-binding domain of the LysR-type transcriptional regulator CbnR in complex with a DNA fragment of the recognition binding site in the promoter region.
   FEBS J. (2018) doi: 10.1111/febs.14380.
2. Kawakami, E.＊, Adachi, N.＊, Senda, T., and Horikoshi, M.
   Leading role of TBP in the establishment of complexity in eukaryotic transcription initiation systems.
   Cell Rep. 21, 3941-3956. (2017). (＊equally contribution)
3. Adachi, N., Aizawa, K., Kratzer, Y., Saijo, S., Shimizu, N., and Senda, T.
   Improved method for soluble expression and rapid purification of yeast TFIIA.
   Protein Expr. Purif. 133, 50-56.(2017).
4. Adachi, N., Senda, T., and Horikoshi, M.
   Uncovering ancient transcription systems with a novel evolutionary indicator.
   Scientific Rep. 6, 27922.(2016).
5. Akai, Y.^＊, Adachi, N.^＊, Hayashi, Y.^＊, Eitoku, M., Sano, N., Natsume, R., Kudo, N., Tanokura, M., Senda, T., and Horikoshi, M. (2010). Structure of the histone chaperone CIA/ASF1-double bromodomain complex linking histone modifications and site-specific histone eviction. Proc. Natl. Acad. Sci. USA 107, 8153-8158. (^＊equally contribution)
6. Adachi, N., Senda, M., Natsume, R., Senda, T., and Horikoshi, M. (2008). Crystal structure of Methanococcus jannaschii TATA box-binding protein. Genes Cells 13, 1127-1140.
7. Nakamura, Y., Umehara, T., Nakano, K., Jang, M.K., Shirouzu, M., Morita, S., Uda-Tochio, H., Hamana, H., Terada, T., Adachi, N., Matsumoto, T., Tanaka, A., Horikoshi, M., Ozato, K., Padmanabhan, B., and Yokoyama, S. (2007). Crystal structure of the human BRD2 bromodomain: insights into dimerization and recognition of acetylated histone H4. J. Biol. Chem. 282, 4193-4201.
8. Padmanabhan, B., Kataoka, K., Umehara, T., Adachi, N., Yokoyama, S., and Horikoshi, M. (2005). Structural similarity between histone chaperone Cia1p/Asf1p and DNA-binding protein NF-kappaB. J. Biochem. 138, 821-829.
9. Adachi, N., Natsume, R., Senda, M., Muto, S., Senda, T., and Horikoshi, M. (2004). Purification, crystallization and preliminary X-ray analysis of Methanococcus jannaschii TATA box-binding protein (TBP). Acta Crystallogr. D 60, 2328-2331.
10. Muto, S., Senda, M., Adachi, N., Suzuki, T., Nagai, R., Senda, T., and Horikoshi, M. (2004). Purification, crystallization and preliminary X-ray diffraction analysis of human oncoprotein SET/TAF-1beta. Acta Crystallogr D 60, 712-714.
11. Padmanabhan, B., Kuzuhara, T., Adachi, N., and Horikoshi, M. (2004). The crystal structure of CCG1/TAF(II)250-interacting factor B (CIB). J. Biol. Chem. 279, 9615-9624.
12. Padmanabhan, B., Adachi, N., Kataoka, K., and Horikoshi, M. (2004). Crystal structure of the homolog of the oncoprotein gankyrin, an interactor of Rb and CDK4/6. J. Biol. Chem. 279, 1546-1552.
13. Miyamoto, S., Suzuki, T., Muto, S., Aizawa, K., Kimura, A., Mizuno, Y., Nagino, T., Imai, Y., Adachi, N., Horikoshi, M., and Nagai, R. (2003). Positive and negative regulation of the cardiovascular transcription factor KLF5 by p300 and the oncogenic regulator SET through interaction and acetylation on the DNA-binding domain. Mol. Cell. Biol. 23, 8528-8541.
14. Kimura, A., Adachi, N., and Horikoshi, M. (2003). Series of vectors to evaluate the position and the order of two different affinity tags for purification of protein complexes. Anal. Biochem. 314, 253-259.
15. Padmanabhan, B., Kataoka, K., Adachi, N., and Horikoshi, M. (2002). Purification, crystallization and preliminary X-ray diffraction analysis of yeast nucleosome-assembly factor Cia1p. Acta Crystallogr. D 58, 1876-1878.
16. Adachi, N., Kimura, A., and Horikoshi, M. (2002). A conserved motif common to the histone acetyltransferase Esa1 and the histone deacetylase Rpd3. J. Biol. Chem. 277, 35688-35695.
17. Adachi, N., Padmanabhan, B., Kataoka, K., Kijima, K., Yamaki, M., and Horikoshi, M. (2002). Purification, crystallization and preliminary X-ray diffraction analysis of yeast regulatory particle non-ATPase subunit 6 (Nas6p). Acta Crystallogr. D 58, 859-860.