Taro Muto Assistant Professor, Institute of Health Biosciences
The University of Tokushima
Forward genetics in man is beneficial, in terms of (i) diagnoses and treatments of genetic diseases and (ii) discoveries of gene functions. However, experimental mating is not available in human genetics. In order to escape this dilemma, I try to establish a novel experimental procedure to genetically identify human disease gene loci without mating the patients with others. Using this technique, one carrier of the genetic mutations would be enough to identify the disease gene loci, if the abnormality is reproducible using patients-derived cells.