Establishment of comprehensive assessment system for iPS cells using rabbit models
Arata Honda Researcher
The aim of this study is to establish experimental models using laboratory rabbits for safety assessment of iPS cells in human regenerative medicine. We try to derive rabbit iPS cells from somatic cells and induce them to differentiate in vitro, according to the methods established in other species with necessary modifications. They are to be transplanted to host rabbits including those of human disease models for assessment of the effectiveness and safety of iPS cell-based medicine. We also derive rabbit nuclear transfer ES cells as alternative cell-therapy resources and thus make our iPS assessment system more comprehensive. We hope that our comprehensive assessment system using rabbit iPS cells will accelerate transition from basic iPS research to its clinical applications in humans.