Control of intestinal microbiota by oral administration of monoclonal dimeric IgA
Reiko Shinkura
| Research Site | The University of Tokyo |
|---|---|
| The Institute of Molecular and Cellular Biosciences | |
| Professor |
Content
Changing in the composition and abundance of gut microbiota can cause a variety of human diseases, including inflammatory and metabolic diseases, cancer and autoimmune diseases. The intestinal IgA is essential to maintain gut homeostasis, although its function is not well understood. Through the study how IgA acts on luminal bacteria, we will identify the monoclonal dimeric IgAs useful for maintenance of gut homeostasis. Using an animal model, we will demonstrate the oral administration of such dimeric IgAs can be an effective therapy to treat diseases caused by imbalanced gut microbiota.
Publication
- Shinsaku Okai1, Fumihito Usui, Shuhei Yokota1, Yusaku Hori, Makoto Hasegawa, Toshinobu Nakamura, Manabu Kurosawa, Seiji Okada, Kazuya Yamamoto, Eri Nishiyama, Hiroshi Mori, Takuji Yamada, Ken Kurokawa, Satoshi Matsumoto, Masanobu Nanno,Tomoaki Naito, Yohei Watanabe, Tamotsu Kato, Eiji Miyauchi, Hiroshi Ohno and Reiko Shinkura. High-affinity monoclonal IgA regulates gut microbiota and prevents colitis in mice, Nat Microbiol, 2016 Jul 4;1(9):16103.
