|Research Site||The University of Tokyo|
|The Institute of Molecular and Cellular Biosciences|
Changing in the composition and abundance of gut microbiota can cause a variety of human diseases, including inflammatory and metabolic diseases, cancer and autoimmune diseases. The intestinal IgA is essential to maintain gut homeostasis, although its function is not well understood. Through the study how IgA acts on luminal bacteria, we will identify the monoclonal dimeric IgAs useful for maintenance of gut homeostasis. Using an animal model, we will demonstrate the oral administration of such dimeric IgAs can be an effective therapy to treat diseases caused by imbalanced gut microbiota.