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Identification of novel physiologically active substances involved in enhancement or disturbance of human homeostasis

Kumiko Saeki (photo)

Kumiko Saeki

Research SiteNational Center for Global Health and Medicine
Research Institute, Department of Disease Control
Division Chief


There remains numerous unsolved issues regarding the regulation of human homeostasis due to lack of appropriate experimental tools. By applying our unique and innovative techniques to produce high-quality brown adipocytes and vascular endothelial cells from human ES/iPS cells, I will identify novel physiologically active substances that are involved in enhancing or disturbing human homeostasis for the development of side-effect-free therapeutics for metabolic syndrome and ischemic diseases, which are recognized as a social problem.


  1. Nishio M, Nakahara M, Sato C, Saeki K, Akutsu H, Umezawa A, Tobe K, Yasuda K, Yuo A, Saeki K. New categorization of human vascular endothelial cells by pro- versus anti-proliferative phenotypes. World J Transl Med 4: 88-100, 2015.
  2. Nakahara M, Nishio M, Saeki K, You A, Saeki K. p38 MAPK regulates type-I versus type-II phenotyping of human vascular endothelial cells. World J Transl Med 4: 101-112, 2015.
  3. Nishio M, Nakahara M, Saeki K, Fujiu K, Iwata H, Manabe I, Yuo A, Saeki K. Pro- versus anti-stenotic capacities of type-I versus type-II human iPS-derived endothelial cells. World J Transl Med 4: 113-122, 2015.