|Research Site||Osaka University|
|Graduate School of Medicine|
|Project Associate Professor|
Living organisms continuously undergo synthesis and degradation of cellular materials. In this dynamic process, homeostasis is maintained when old components are replaced with fresh ones and it reaches a new state when components are replaced with different types. Since degraded components are reused as building blocks, degradation system can be the driving force of the maintenance or change of homeostasis. In this study, we focus on autophagy, one of the major degradation systems, and investigate the mechanism of the maintenance and transfiguration of homeostasis in living body by understanding the physiological role of autophagy.