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Multiple organ homeostasis by the bone

Yoshio Katayama (photo)

Yoshio Katayama

Research SiteKobe University
Kobe University Hospital (Hematology)
Junior Associate Professor


We have elucidated the existence of intercommunication between diverse organs, such as the control of hematopoiesis by the central/peripheral nervous system through the regulation of bone metabolism. It is thought that such network would be functional in any organs. Although the brain has been recognized as the central control of all organs, this study will prove a new concept, "the bone-pinnacled functional orchestration of multiple organs". The unexpected application of existing drugs to diverse organs and the new approach to preemptive medicine will be available by the elucidation of this new multiple organ network.


  1. Asada N, Sato M, Katayama Y. Communication of bone cells with hematopoiesis, immunity and energy metabolism. Bonekey Reports 2015, 4, 748. (invited review article)
  2. Sato M, Asada N, Kawano Y, Wakahashi K, Minagawa K, Kawano H, Sada A, Ikeda K, Matsui T, Katayama Y. Osteocytes regulate primary lymphoid organs and fat metabolism. Cell Metabolism 2013, 18, 749-758.
  3. Asada N, Katayama Y, Sato M, Minagawa K, Wakahashi K, Kawano H, Kawano Y, Sada A, Ikeda K, Matsui T, Tanimoto M. Matrix-embedded osteocytes regulate mobilization of hematopoietic stem/progenitor cells. Cell Stem Cell 2013, 12: 737-747.