科学技術振興機構 さきがけ エピジェネティクスの制御と生命機能 エピジェネティクスの制御と生命機能さきがけ独立行政法人科学技術振興機構

研究成果

鈴木　孝禎 （Takayoshi Suzuki)

論文

  1. KDM1 is a novel therapeutic target for the treatment of gliomas、Gangadhara R Sareddy, Binoj C. Nair, Samaya K Krishnan, Vijaya Gonugunta, Quan-guang Zhang, Takayoshi Suzuki, Naoki Miyata, Andrew Brenner, Darrell W. Brann, and Ratna K. Vadlamudi,Oncotarget,November17,2012
  2. "Targeting PELP1-KDM1 axis as a potential therapeutic strategy for breast cancer"Valerie Cortez,Monica Mann,Seshidhar Tekmal,Takayoshi Suzuki ,Naoki Miyata,Cristian Rodriguez-Aguayo,Gabriel Lopez-Berestein, Anil K. Sood,and Ratna K. Vadlamudi,Breast Cancer Research
    2012, 14:R108 
  3. ”Synthesis and biological activity of optically active NCL-1, a lysinespecific demethylase 1 selective inhibitor”Daisuke Ogasawara, Takayoshi Suzuki,* Koshiki Mino, Rie Ueda, Mohammed Naseer Ahmed Khan, Takuya Matsubara, Koichi Koseki, Makoto Hasegawa, Ryuzo Sasaki, Hidehiko Nakagawa, Tamio Mizukami* and Naoki Miyata*Bioorganic & Medicinal Chemistry　Vol.19, Issue 12, 15 June 2011, p3702-3708
  4. 　"An Unexpected Example of Protein-Templated Click Chemistry"Takayoshi Suzuki,* Yosuke Ota, Yuki Kasuya, Motoh Mutsuga, Yoko Kawamura, Hiroki Tsumoto, Hidehiko Nakagawa, M. G. Finn,* and Naoki Miyata* Angewandte Chemie International Edition 16 AUG 2010　　　　　　　　　　　　　　　　　　　　　
  5. " Design, Synthesis, Enzyme-inhibitory Activity, and Effect on Human Cancer Cells of a Novel Series of Jumonji Domain-Containing Protein 2 Histone Demethylase Inhibitors"Shohei Hamada, Takayoshi Suzuki,* Koshiki Mino, Koichi Koseki, Felix Oehme, Ingo Flamme, Hiroki Ozasa, Yukihiro Itoh, Daisuke Ogasawara, Haruka Komaarashi, Aiko Kato, Hiroki Tsumoto, Hidehiko Nakagawa, Makoto Hasegawa, Ryuzo Sasaki, Tamio Mizukami,* Naoki Miyata.*
    J.Med.Chem.2010,53(15),pp5629-5638
  6. “Identification of cell-active lysine specific demethylase 1-selective inhibitors” Rie Ueda, Takayoshi Suzuki, Koshiki Mino, Hiroki Tsumoto, Hidehiko Nakagawa, Makoto Hasegawa, Ryuzo Sasaki, Tamio Mizukami, and Naoki Miyata. J. Am. Chem. Soc. 2009, 131, 17536-17537.
  7. “Multiple Bond-Conjugated Photoinduced Nitric Oxide Releaser Based on Acceptor-Donor-Acceptor Structure Working with Two-Photon Excitation” Kazuhiro Hishikawa, Toshiaki Furuta, Kiyoshi Fukuhara, Hiroki Tsumoto, Takayoshi Suzuki and Naoki Miyata. Bioorg. Med. Chem. Lett. in press.
  8. “Non-Hydroxamate Histone Deacetylase Inhibitors” Takayoshi Suzuki and Naoki Miyata. Frontiers in Medicinal Chemistry 2009, 4, 619-641.
  9. “Explorative Study on Isoform-Selective Histone Deacetylase Inhibitors” Takayoshi Suzuki. Chem. Pharm. Bull. 2009, 57, 897-906.
  10. “Identification of a non-peptide sirtuin inhibitor containing N-thioacetyl lysine” Takayoshi Suzuki, Tomomi Asaba, Erika Imai, Hiroki Tsumoto, Hidehiko Nakagawa and Naoki Miyata. Bioorg. Med. Chem. Lett. 2009, 19, 5670-5672.
  11. “Design, synthesis, enzyme inhibition and tumor cell growth inhibition of 2-anilinobenzamide derivatives as SIRT1 inhibitors” Takayoshi Suzuki, Keiko Imai, Erika Imai, Shinsuke Iida, Ryuzo Ueda, Hiroki Tsumoto, Hidehiko Nakagawa and Naoki Miyata. Bioorg. Med. Chem. 2009, 17, 5900-5905.
  12. “Photoinduced Nitric Oxide Release from a Hindered Nitrobenzene Derivative by Two-Photon Excitation” Kazuhiro Hishikawa, Hidehiko Nakagawa, Toshiaki Furuta, Kiyoshi Fukuhara, Hiroki Tsumoto, Takayoshi Suzuki, and Naoki Miyata. J. Am. Chem. Soc. 2009, 131, 7488-7489.
  13. “Inhibition of Human Sirtuins by In Situ Generation of an Acetylated Lysine-ADP-ribose Conjugate” Tomomi Asaba, Takayoshi Suzuki, Rie Ueda, Hiroki Tsumoto, Hidehiko Nakagawa, and Naoki Miyata. J. Am. Chem. Soc. 2009, 131, 6989-6996.
  14. “Design, Synthesis, and Biological Activity of Boronic acid-Based Histone Deacetylase Inhibitors” Nobuaki Suzuki, Takayoshi Suzuki, Yosuke Ota, Tatsuya Nakano, Masaaki Kurihara, Haruhiro Okuda, Takao Yamori, Hiroki Tsumoto, Hidehiko Nakagawa, and Naoki Miyata. J. Med. Chem. 2009, 52, 2902-2922.
  15. “Synthesis and activity of N-oxalylglycine and its derivatives as Jumonji C-domain-containing histone lysine demethylase inhibitors” Shohei Hamada, Tae-Dong Kim, Takayoshi Suzuki, Yukihiro Itoh, Hiroki Tsumoto, Hidehiko Nakagawa, Ralf Janknecht and Naoki Miyata. Bioorg. Med. Chem. Lett. 2009, 19, 2852-2855.
  16. “Identification of G protein-coupled receptor 120-selective agonists derived from PPARg agonists” Takayoshi Suzuki, Sou-ichi Igari, Akira Hirasawa, Mie Hata, Masaji Ishiguro, Hiroki Fujieda, Yukihiro Itoh, Tatsuya Hirano, Hidehiko Nakagawa, Michitaka Ogura, Makoto Makishima, Gozoh Tsujimoto and Naoki Miyata. J. Med. Chem. 2008, 51, 7640-7644.
  17. “Microtuble Acetylation Through HDAC6 Inhibition Results in Increased Transfection Efficiency” Erin E. Vaughan,
    R. Christopher Geiger, Aaron M. Miller, Takayoshi Suzuki, Naoki Miyata and David A. Dean. Mol. Ther. 2008, 16, 1841-1847.
  18. “Photoactivatable HNO-releasing Compounds Using the retro-Diels-Alder Reaction” Yusuke Adachi, Hidehiko Nakagawa, Kazuya Matsuo, Takayoshi Suzuki and Naoki Miyata. Chem. Commun. 2008, 5149-5151.
  19. “Preparation of C60-based active esters and coupling of C60 moiety to amines or alcohols” Hiroki Tsumoto, Katsumasa Takahashi, Takayoshi Suzuki, Hidehiko Nakagawa, Kohfuku Kohda and Naoki Miyata. Bioorg. Med. Chem. Lett. 2008, 18, 657-660.
  20. “HDAC6-selective inhibitors” Yukihiro Itoh, Takayoshi Suzuki and Naoki Miyata. Igaku no ayumi 2008, 224, 71-74.
  21. “Isoform Selective Histone Deacetylase Inhibitors” Yukihiro Itoh, Takayoshi Suzuki and Naoki Miyata. Curr. Pharm. Design 2008, 14, 529-544.
  22. “Design, Synthesis, Structure-Selectivity Relationship, and Effect on Human Cancer Cells of a Novel Series of Histone Deacetylase 6-Selective Inhibitors” Yukihiro Itoh, Takayoshi Suzuki, Akiyasu Kouketsu, Nobuaki Suzuki, Satoko Maeda, Minoru Yoshida, Hidehiko Nakagawa and Naoki Miyata. J. Med. Chem. 2007, 50, 5425-5438.
  23. “A new series of anti-prion compounds; pyrazolone derivatives have the potent activity of inhibiting protease-resistant prion protein accumulation” Ayako Kimata, Hidehiko Nakagawa, Ryo Ohyama, Tomoko Fukuuchi, Shigeru Ohta, Katsumi Doh-ura, Takayoshi Suzuki and Naoki Miyata. J. Med. Chem. 2007, 50, 5053-5056.
  24. “Design, Synthesis and Biological Activity of Folate Receptor-targeted Prodrugs of Thiolate Histone Deacetylase Inhibitors” Takayoshi Suzuki, Shinya Hisakawa, Yukihiro Itoh, Nobuaki Suzuki, Katsumasa Takahashi, Masatoshi Kawahata, Kentaro Yamaguchi, Hidehiko Nakagawa and Naoki Miyata. Bioorg. Med. Chem. Lett. 2007, 17, 4208-4212.
  25. “Proteome analyses of the growth inhibitory effects of NCH-51, a novel histone deacetylase inhibitor, on lymphoid malignant cell” Takaomi Sanda, Takashi Okamoto, Yuto Uchida, Hidehiko Nakagawa, Shinsuke Iida, Satoshi Kayukawa, Takayoshi Suzuki, Tadashi Oshizawa, Takayoshi Suzuki, Naoki Miyata and Ryuzo Ueda. Leukemia 2007, 21, 2344-2353.
  26. “Synthesis and biological evaluation of 2-nonylaminopyridine derivatives as PPAR ligands” Shinya Usui, Hiroki Fujieda, Takayoshi Suzuki, Naoaki Yoshida, Hidehiko Nakagawa, Michitaka Ogura, Makoto Makishima, and Naoki Miyata. Chem. Pharm. Bull. 2007, 55, 1053-1059.
  27. “Phenylpropanoic acid derivatives bearing a benzothiazole ring as PPARδ-selective agonists” Hiroki Fujieda, Shinya Usui, Takayoshi Suzuki, Hidehiko Nakagawa, Michitaka Ogura, Makoto Makishima, and Naoki Miyata. Bioorg. Med. Chem. Lett. 2007, 17, 4351-4357.
  28. “Novel mitochondria-localizing TEMPO derivative for measurement of cellular oxidative stress in mitochondria” Shizuka Ban, Hidehiko Nakagawa, Takayoshi Suzuki and Naoki Miyata. Bioorg. Med. Chem. Lett. 2007, 17, 2055-2058.
  29. “Identification of a potent and stable antiproliferative agent by the prodrug formation of a thiolate histone deacetylase inhibitor” Takayoshi Suzuki, Shinya Hisakawa, Yukihiro Itoh, Sakiko Maruyama, Mineko Kurotaki, Hidehiko Nakagawa and Naoki Miyata. Bioorg. Med. Chem. Lett. 2007, 17, 1558-1561.
  30. “Novel membrane-localizing TEMPO derivatives for measurement of cellular oxidative stress at the cell membrane” Shizuka Ban, Hidehiko Nakagawa, Takayoshi Suzuki and Naoki Miyata. Bioorg. Med. Chem. Lett. 2007, 17, 1451-1454.
  31. 「細胞内部特異的酸化ストレス計測を目指したスピンプローブの開発」中川秀彦、伴静華、鈴木孝禎、宮田直樹　電子スピンサイエンス 2007, 5, 37-46.
  32. 「ヒストン脱アセチル化酵素を分子標的とした抗がん剤の探索研究」鈴木孝禎、伊藤幸裕、宮田直樹　PHARMA VISION NEWS 2007, 10, 12-16.
  33. “Hydroxyl radical scavenging by edaravone derivatives: Efficient scavenging by 3- methyl-1-(pyridin-2-yl)-5-pyrazolone with an intramolecular base” Hidehiko Nakagawa, Ryo Ohyama, Ayako Kimata, Takayoshi Suzuki and Naoki Miyata. Bioorg. Med. Chem. Lett. 2006, 16, 5939-5942.
  34. “2-Anilinobenzamides as SIRT inhibitors” Takayoshi Suzuki, Keiko Imai, Hidehiko Nakagawa and Naoki Miyata. ChemMedChem 2006, 1, 1059-1062.
  35. “Highly Potent and Selective Histone Deacetylase 6 Inhibitors Desigened Based on a Small-molecular Substrate” Takayoshi Suzuki, Akiyasu Kouketsu, Shinya Hisakawa, Yukihiro Itoh, Satoko Maeda, Minoru Yoshida, Hidehiko Nakagawa and Naoki Miyata. J. Med. Chem. 2006, 49, 4809-4812.
  36. “Benzimidazole Derivatives Bearing Substituted Biphenyls as Hepatitis C Virus NS5B RNA-dependent RNA Polymerase Inhibitors: Structure-Activity Relationship Studies and Identification of a Potent and Highly Selective HCV NS5B Inhibitor JTK-109” Shintaro Hirashima, Takayoshi Suzuki, Tomio Ishida, Satoru Noji, Shinji Yata, Izuru Ando, Masakazu Komatsu, Satoru Ikeda and Hiromasa Hashimoto. J. Med. Chem. 2006, 49, 4721-4736.
  37. “Identification of novel PPARa ligands by the structural modification of a PPARg ligand” Shinya Usui, Hiroki Fujieda, Takayoshi Suzuki, Naoaki Yoshida, Hidehiko Nakagawa and Naoki Miyata. Bioorg. Med. Chem. Lett. 2006, 16, 3249-3254. 33) “Benzimidazole Inhibitors of Hepatitis C Virus NS5B Polymerase: Identification of 2-[(4-Diarylmethoxy)phenyl]benzimidazole” Tomio Ishida, Takayoshi Suzuki, Shintaro Hirashima, Kenji Mizutani, Atsuhito Yoshida, Izuru Ando, Satoru Ikeda, and Hiromasa Hashimoto. Bioorg. Med. Chem. Lett. 2006, 16, 1859-1863.
  38. “Rational Design of Non-hydroxamate Histone Deacetylase Inhibitors” Takayoshi Suzuki and Naoki Miyata. Mini Rev. Med. Chem. 2006, 6, 515-526.
  39. “Epigenetic Control Using Natural Products and Synthetic Molecules” Takayoshi Suzuki and Naoki Miyata. Curr. Med. Chem. 2006, 13, 935-958.
  40. “Novel Human Histone Deacetylase Inhibitors: Design, Synthesis, Enzyme Inhibition, and Cancer Cell Growth Inhibition of SAHA-Based Non-hydroxamates” Takayoshi Suzuki, Yuki Nagano, Akiyasu Kouketsu, Azusa Matsuura, Sakiko Maruyama, Mineko Kurotaki, Hidehiko Nakagawa, and Naoki Miyata. J. Med. Chem. 2005, 48, 1019-1032.
  41. “Identification of a potent non-hydroxamate histone deacetylase inhibitor by mechanism-based drug design” Takayoshi Suzuki, Azusa Matsuura, Akiyasu Kouketsu, Hidehiko Nakagawa, and Naoki Miyata. Bioorg. Med. Chem. Lett. 2005, 15, 331-335.
  42. “Design and synthesis of non-hydroxamate histone deacetylase inhibitors: identification of a selective histone acetylating agent” Takayoshi Suzuki, Azusa Matsuura, Akiyasu Kouketsu, Shinya Hisakawa, Hidehiko Nakagawa and Naoki Miyata. Bioorg. Med. Chem. 2005, 13, 4332-4342.
  43. “Phtoinduced Nitric Oxide Release from Nitrobenzene Derivatives” Takayoshi Suzuki, Osamu Nagae, Yuka Kato, Hidehiko Nakagawa, Kiyoshi Fukuhara, and Naoki Miyata. J. Am. Chem. Soc. 2005, 127, 11720-11726.
  44. “Design, synthesis and biological activity of novel PPARg ligands based on rosiglitazone and 15d-PGJ2” Shinya Usui, Takayoshi Suzuki, Yoshifumi Hattori, Kazuma Etoh, Hiroki Fujieda, Makoto Nishizuka, Masayoshi Imagawa, Hidehiko Nakagawa, Kohfuku Kohda, and Naoki Miyata. Bioorg. Med. Chem. Lett. 2005, 15, 1547-1551.
  45. Non-hydroxamate Histone Deacetylase Inhibitors” Takayoshi Suzuki and Naoki Miyata. Curr. Med. Chem. 2005, 12, 2867-2880.
  46. “Molecularly Targeted Approach to Cancer Therapy: Design, Synthesis and Biological Activity of Non-hydroxamate Histone Deacetylase Inhibitors” Takayoshi Suzuki, Hidehiko Nakagawa, and Naoki Miyata. J. Syn. Org. Chem. Jpn. 2005, 63, 1004-1015.
  47. “Frontiers of development of histone deacetylase inhibitors” Takayoshi Suzuki and Naoki Miyata. Farumashia 2005, 41, 523-527.
  48. “Thiol-based SAHA analogues as potent histone deacetylase inhibitors” Takayoshi Suzuki, Akiyasu Kouketsu, Azusa Matsuura, Arihiro Kohara, Shin-ichi Ninomiya, Kohfuku Kohda, and Naoki Miyata. Bioorg. Med. Chem. Lett. 2004, 14, 3313-3317.
  49. “Novel Histone Deacetylase Inhibitors: Design, Synthesis, Enzyme Inhibition, and Binding Mode Study of SAHA-Based Non-hydroxamates” Takayoshi Suzuki, Yuki Nagano, Azusa Matsuura, Arihiro Kohara, Shin-ichi Ninomiya, Kohfuku Kohda, and Naoki Miyata. Bioorg. Med. Chem. Lett. 2003, 13, 4321-4326.
  50. “Superacid-Catalyzed Electrocyclization of Diphenylmethyl Cations to Fluorenes. Kinetic and Theoretical Revisit Supporting the Involvement of Ethylene Dications” Tomohiko Ohwada, Takayoshi Suzuki, and Koichi Shudo. J. Am Chem. Soc. 1998, 120, 4629-4637
  51. “Superacid-Catalyzed Electrocyclization of 1-Phenyl-2-propen-1-ones to 1-Indanones. Kinetic and Theoretical Studies of Electrocyclization of Oxonium-Carbenium Dications” Takayoshi Suzuki, Tomohiko Ohwada, and Koichi Shudo. J. Am Chem. Soc. 1997, 119, 6774-6780.
  52. “Structures and Reactivities of Ethylene Dication Electrophiles” Tomohiko Ohwada, Takahisa Yamazaki, Takayoshi Suzuki, Shinichi Saito, and Koichi Shudo. J. Am Chem. Soc. 1996, 118, 6220-6224.

【発表】

  1. 鈴木孝禎，伊藤幸裕，纐纈章泰，前田里子，吉田稔，中川秀彦，宮田直樹 HDAC6選択的阻害薬の創製とその応用
    日本ケミカルバイオロジー学会 第4回年会，2009年5月18日 （神戸）
  2. 鈴木孝禎，浅場智美，津元裕樹，中川秀彦，宮田直樹 触媒メカニズムに基づいたSIRT 阻害薬の創製 第7回次世代を担う有機化学シンポジウム，2009年7月24日 （大阪）
  3. 鈴木孝禎、今井景子、中川秀彦、宮田直樹 新規SIRT 阻害薬の設計、合成と酵素阻害活性評価 日本薬学会第126年会．2006年3月28-30日（仙台）P30[S]pm-540
  4. 鈴木孝禎，纐纈章泰，中川秀彦，宮田直樹 新規HDAC6 選択的阻害薬の設計、合成と生物活性評価 第４回次世代を担う有機化学シンポジウム．2006年5月19-20日（大阪）1-11
  5. Takayoshi Suzuki, Akiyasu Kouketsu, Yukihiro Itoh, Shinya Hisakawa, Hidehiko Nakagawa, Naoki Miyata Discovery of novel histone deacetylase 6 selective inhibitors ICOB-5 & ISCNP-25 IUPAC. 2006年7月23-28日（Kyoto）P-440
  6. Takayoshi Suzuki, Akiyasu Kouketsu, Yukihiro Itoh, Shinya Hisakawa, Satoko Maeda, Minoru Yoshida, Hidehiko Nakagawa, Naoki Miyata Design and synthesis of histone deacetylase 6 selective inhibitors. 232nd ACS National Meeting, 2006年9月10-14日 (San Francisco, U.S.A.)
  7. 鈴木孝禎、中川秀彦、宮田直樹 チオール系ヒストン脱アセチル化酵素阻害薬の癌細胞増殖抑制作用 日本薬学会第125年会．2005年3月29-31日（東京）31-1055 W019-09
  8. 鈴木孝禎、中川秀彦、加藤友香、長江修、福原潔、宮田直樹 ニトロベンゼン構造を有する光誘起型NOドナーの創製 第３回次世代を担う有機化学シンポジウム．2005年5月20-21日（東京）1-02
  9. 鈴木孝禎，三田貴臣，飯田真介，上田龍三，中川秀彦，宮田直樹 チオール系ヒストンデアセチラーゼ阻害剤の癌細胞増殖抑制活性 第64回日本癌学会学術総会．2005年9月14-16日（札幌）PA2-0745
  10. Takayoshi Suzuki, Yuki Nagano, Akiyasu Kouketsu, Azusa Matsuura, Shinya Hisakawa, Hidehiko Nakagawa and, Naoki Miyata Discovery of Non-hydroxamate Histone Deacetylase Inhibitors Pacifichem 2005. 2005年12月15-20日（Honolulu）poster373
  11. 鈴木孝禎、纐纈章泰、松浦梓、小原有弘、二宮真一、幸田光復、宮田直樹 非ヒドロキサム酸系ヒストン脱アセチル化酵素阻害剤の設計・合成と酵素阻害活性評価 日本薬学会第124年会．2004年3月29日（大阪
  12. 鈴木孝禎、長野友紀、纐纈章泰、松浦梓、幸田光復、宮田直樹 ヒドロキサム酸を持たない新規ヒストン脱アセチル化酵素阻害薬の設計、合成と生理活性評価 第2回次世代を担う有機化学シンポジウム． 2004年6月25日（東京）
  13. Takayoshi Suzuki, Akiyasu Kouketsu, Azusa Matuura, Kohfuku Kohda, Naoki Miyata Synthesis and Biological Activity of Thio-Based Small Mollecule Inhibitors of Human Histone Deacetylases 15th Conference on Organic Chemistry (IUPAC ICOS-15). 2004年8月3日(Nagoya)
  14. 鈴木孝禎、松浦　梓、纐纈章泰、中川秀彦、宮田直樹 新規非ヒドロキサム酸系ヒストン脱アセチル化酵素阻害薬の
    設計と合成 第30回反応と合成の進歩シンポジウム． 2004年10月20日（札幌）
  15. 鈴木孝禎、長野友紀、纐纈章泰、松浦梓、中川秀彦、宮田直樹 新規非ヒドロキサム酸系ヒストン脱アセチル化酵素阻害剤の設計、合成と生物活性評価 第23回メディシナルケミストリーシンポジウム． 2004年11月24日（つくば）
  16. Suzuki, T., Nagano, Y., Kohara, A., Sudou, T., Kohda, K., Miyata, N. Discovery of novel histone deacetylase inhibitors, Fifth AFMC Internatinoal Medicinal Chemistry Symposium, Kyoto, October 14-17, 2003.
  17. 鈴木孝禎、長野友紀、纐纈章泰、小原有弘、二宮真一、幸田光復、宮田直樹 新規ヒストン脱アセチル化酵素阻害剤の創製、 名古屋大学21世紀COE有機化学若手研究会、名古屋、2003年12月12日

【講演】

  1. ｢触媒メカニズムに基づいた酵素阻害薬の創製研究｣創薬懇話会2009；2009年12月11日（岐阜）
  2. ｢アイソフォーム選択的ヒストン脱アセチル化酵素阻害薬の創製研究｣日本薬学会第129年会；2009年3月26日（京都）
  3. ｢ヒストン脱アセチル化酵素阻害薬の医薬化学｣ 第267回CBI学会研究講演会；2006年9月27日（東京）
  4. ｢生命現象の解明及び創薬を目指したヒストン脱アセチル化酵素阻害薬の探索｣
    第7回創薬ビジョンシンポジウム；2006年2月22日（東京）
  5. “Rational Design of Non-hydroxamate Histone Deacetylase Inhibitors” Pacifichem 2005; Dec. 19, 2005 (Honolulu).