科学技術振興機構 さきがけ エピジェネティクスの制御と生命機能 エピジェネティクスの制御と生命機能さきがけ独立行政法人科学技術振興機構

研究成果

岡田　由紀 （Yuki Okada)

欧文原著

  1. Yamagata K,Okada Y*,(2011).Understanding paternal genome demethylation through live-cell imaging and siRNA.Cell Mol Life Sci.2011 Jan 15.
  2. Okada Y, Sawa H, Tanaka S, Takada A, Suzuki S, Hasegawa H, Umemura T, Fujisawa J-I, Tanaka Y, Hall WW, Nagashima K. (2000). Transcriptional activation of JC virus (JCV) by human T-lymphotropic virus type I (HTLV-I) Tax protein in human neuronal cell lines. J. Biol. Chem. 275, 17016-17023.
  3. Yamashita S, Mochizuki N, Ohba Y, Tobiume M, Okada Y, Sawa H, Nagashima K, Matsuda M. (2000). CalDAG-GEFIII activation of Ras, R-Ras, and Rap1. J. Biol. Chem. 275:25488-25493.
  4. Kimura T, Mitsui I, Okada Y, Furuya T, Ochiai K, Umemura T, Itakura C. (2001). Distribution of rabbit haemorrhagic disease virus RNA in experimentally infected rabbits. J. Comp. Pathol. 124:134-141.
  5. Suzuki S, Sawa H, Komagome R, Orba Y, Yamada M, Okada Y, Ishida Y, Nishihara H, Tanaka S, Nagashima K. (2001). Broad distribution of the JC virus receptor contrasts with a marked cellular restriction of virus replication. Virology. 286: 100-112.
  6. Safak M, Barrucco R, Darbinyan A, Okada Y, Nagashima K Khalili K. (2001). Interaction of JC virus agno protein with T antigen modulates transcription and replication of the viral genome in glial cells. J. Virol. 75: 1476-1486.
  7. Okada Y, Endo S, Takahashi H, Sawa H, Umemura T, Nagashima K. (2001). Distribution and function of JCV agnoprotein. J. Neurovirol. 7: 302-306.
  8. Okada Y, Sawa H, Endo S, Orba Y, Umemura T, Nishihara H, Stan AC, Tanaka S, and Nagashima K. (2002). Expression of JC virus (JCV) agnoprotein in progressive multifocal leukoencephalopathy (PML) brain. Acta Neuropathogica. 104: 130-6.
  9. Kobayashi Y*, Watanabe M*, Okada Y*, Sawa H, Takai H, Nakanishi M, Kawase Y, Suzuki H, Nagashima K, Ikeda K, Motoyama N. (2002). Hydrocephalus, situs inversus, chronic sinusitis, and male infertility in DNA polymerase λ-deficient mice: Possible implications for the pathogenesis of immotile cilia syndrome. Mol. Cell. Biol. 8: 2769-76. (*Kobayashi Y, Watanabe M, Okada Y were equally contributed)
  10. Yoshida H, Okada Y, Kinoshita N, Hara H, Sasaki M, Sawa H, Nagashima K, Mak TW, Ikeda K, Motoyama N. (2002). Differential requirement for Apaf1 and Bcl-XL in the regulation of programmed cell death during development. Cell Death Differentiation. 11:1273-6
  11. Takai H, Naka K, Okada Y, Watanabe M, Harada N, Saito S, Anderson CW, Appella E, Nakanishi M, Suzuki H, Nagashima K, Sawa H, Ikeda K, Motoyama N. (2002). Chk2-deficient mice exhibit radioresistance and defective p53-mediated transcription. EMBO J. 21(19):5195-205.
  12. Endo S, Okada Y, Orba Y, Nishihara H, Tanaka S, Nagashima K, Sawa H.(2003). JC virus agnoprotein colocalizes with tubulin. J. Neurovirol.;9 Suppl 1:10-4.
  13. Qu Q, Sawa H, Suzuki T, Semba S, Henmi C, Okada Y, Tsuda M, Tanaka S, Atwood WJ, Nagashima K. (2004). Nuclear entry mechanism of the human polyomavirus JC virus-like particle: role of importins and the nuclear pore complex. J. Biol. Chem. 279:27735-42.
  14. Okada Y*, Suzuki T*, Sunden Y, Orba Y, Kose S, Imamoto N, Takahashi H, Tanaka S, Hall WW, Nagashima K, Sawa H. (2005). Dissociation of heterochromatin protein 1 from lamin B receptor induced by human polyomavirus agnoprotein: role in nuclear egress of viral particles. EMBO Rep. 6:452-7. (*Okada Y and Suzuki T were equally contributed).--- This article was featured in Nat. Rev. Microbiol., Vol. 3, 2005.
  15. Suzuki T, Okada Y, Semba S, Orba Y, Yamanouchi S, Endo S, Tanaka S, Fujita T, Kuroda S, Nagashima K, Sawa H. (2005). Identification of FEZ1 as a protein that interacts with JC virus agnoprotein and microtubules: role of agnoprotein-induced dissociation of FEZ1 from microtubules in viral propagation. J Biol Chem. 280:24948-56.
  16. Okada Y, Feng Q, Lin Y, Jiang Q, Li Y, Coffield VM, Su L, Xu G, Zhang Y. (2005). hDOT1L links histone methylation to leukemogenesis. Cell. 121:167-78.
  17. Okada Y, Jiang Q, Lemieux M, Jeannotte L, Su L, Zhang Y. (2006). Leukemic transformation by CALM-AF10 involves upregulation of Hoxa5 by hDOT1L. Nat. Cell. Biol. 8:1017-24.
  18. Sunden Y, Semba S, Suzuki T, Okada Y, Orba Y, Nagashima K, Umemura T, Sawa H. (2007). Identification of DDX1 as a JC virus transcriptional control region-binding protein. Microbiol Immunol.51:327-37.
  19. Sunden Y, Semba S, Suzuki T, Okada Y, Orba Y, Nagashima K, Umemura T, Sawa H. (2007). DDX1 promotes proliferation of the JC virus through transactivation of its promoter. Microbiol Immunol. 51:339-47.
  20. Okada Y, Scott G, Ray MK, Mishina Y, Zhang Y. (2007). Histone demethylase JHDM2A is critical for Tnp1 and Prm1 transcription and spermatogenesis. Nature. 450:119-23.
  21. Tateishi K, Okada Y, Kallin EM, Zhang Y. (2009). Role of Jhdm2a in regulating metabolic gene expression and obesity resistance. Nature. 458: 757-61.
  22. Okada Y, Tateishi K, Zhang Y.(2009). Histone Demethylase JHDM2A Is Involved in Male Infertility and Obesity.J Androl. 2009 Oct 29 (on-line).
  23. Okada Y, Yamagata K, Hong KH, Wakayama T, Zhang Y. A role for elongator in zygotic paternal genome demethylation. Nature (in press).
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欧文総説

  1. 岡田由紀、Yi Zhang. 「ヒストンメチル化と白血病発症」、 血液フロンティア、Vol. 16, No.1, 医薬ジャーナル社、2006.
  2. 岡田由紀、Yi Zhang. 「精子形成におけるヒストン脱メチル化酵素Jhdm2aの役割」、 実験医学、Vol. 26, No.9, 羊土社、2008.