科学技術振興機構 さきがけ エピジェネティクスの制御と生命機能 エピジェネティクスの制御と生命機能さきがけ独立行政法人科学技術振興機構

研究成果

菅野　達夫 （KANNO, Tatsuo)

原著欧文論文

  1. Kanno, T., Bucher, E., Daxinger, L., Huettel, B., Kreil, D.P., Breinig, F., Lind, M., Schmitt, M., Matzke, A.J.M. and Matzke, M. (2010) RNA-directed DNA methylation and plant development require an IWR1-like transcription factor. EMBO Rep., 11, 65-71.
  2. Lahmy, S., Pontier, D., Cavel, E, Vega, D., El-Shami, M, Kanno, T., and Lagrange, T. (2009) PolV(PolIVb) function in RNA-directed DNA methylation requires the conserved active site and an additional plant-specific subunit. Proc. Natl. Acad. Sci., 106, 941-946.
  3. Daxinger, L., Kanno, T., Bucher, E., Van der Winden, J., Naumann, U., Matzke, A.J.M. and Matzke, M. (2009) A stepwise pathway for biogenesis of 24-nt secondary siRNAs and spreading of DNA methylation. EMBO J., 28, 48-57.
  4. Kanno, T., Bucher, E., Daxinger, L., Huettel, B., Boehmdorfer, G., Gregor, W., Kreil, D.P., Matzke, M. and Matzke, A.J.M. (2008) An SMC hinge domain-containing protein is required for RNA-directed DNA methylation. Nat. Genet., 40, 670-675
  5. Huettel, B., Kanno, T., Daxinger, L., Aufsatz, W., Matzke, A.J. and Matzke, M. (2006) Endogenous targets of RNA-directed DNA methylation and Pol IV in Arabidopsis. EMBO J. 25, 2828-2836
  6. Kanno, T., Aufsatz, W., Jaligot, E., Mette, M.F., Matzke, M. and Matzke, A.J. (2005) A SNF2-like protein facilitates dynamic control of DNA methylation. EMBO Rep., 6, 649-655.
  7. Kanno, T.,Huettel, B., Mette, M.F., Aufsatz, W., Jaligot, E., Daxinger, L., Kreil, D.P., Matzke, M. and Matzke, A.J. (2005) Atypical RNA polymerase subunits required for RNA-directed DNA methylation. Nat. Genet., 37, 761-765.
  8. Matzke, M., Gregor, W., Mette, M.F., Aufsatz, W.,Kanno, T., Jakowitsch, J. and Matzke, A.J. (2004) Endogenous pararetroviruses of allotetraploid Nicotiana tabacum and its diploid progenitors, N. sylvestris and N. tomentosiformis. Biological Journal of the Linnean Sociaty, 82, 627-638.
  9. Kanno, T., Mette, M.F., Kreil, D.P., Aufsatz, W., Matzke, M. and Matzke, A.J. (2004) Involvement of putative SNF2 chromatin remodeling protein DRD1 in RNA-directed DNA methylation. Curr. Biol., 14, 801-805.
  10. Mette, M.F., Kanno, T., Aufsatz, W., Jakowitsch, J., van der Winden, J., Matzke, M.A. and Matzke, A.J. (2002) Endogenous viral sequences and their potential contribution to heritable virus resistance in plants. EMBO J., 21, 461-469.
  11. Matzke, M., Mette, M.F., Jakowitsch, J.,Kanno, T., Moscone, E.A., van der Winden, J. and Matzke, A.J. (2001) A test for transvection in plants: DNA pairing may lead to trans-activation or silencing of complex heteroalleles in tobacco. Genetics., 158, 451-461.
  12. Kanno, T., Naito, S. and Shimamoto, K. (2000) Post-transcriptional gene silencing in cultured rice cells. Plant Cell Physiol., 41, 321-326.
  13. Naito, S., Inaba-Higano, K., Kumagai, T., Kanno, T., Nambara, E., Fujiwara, T., Chino, M. and Komeda, Y. (1994) Maternal effects of mto1 mutation, that causes overaccumulation of soluble methionine, on the expression of a soybean・conglycinin gene promoter-GUS fusion in transgenic Arabidopsis thaliana. Plant Cell Physiology, 35, 1057-1063.
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欧文総説

  1. Matzke, M., Kanno, T., Daxinger, L., Huettel, B. and Matzke, A. J. (2009) RNA-mediated chromatin-based silencing in plants. Curr Opin Cell Biol., Feb 23. [Epub ahead of print]
  2. Matzke, M., Kanno, T., Huettel, B., Daxinger, L., Matzke, A.J. (2007) Targets of RNA-directed DNA methylation. Curr Opin Plant Biol., 10, 512-519.
  3. Huettel, B., Kanno, T., Daxinger, L., Bucher, E., van der Winden, J., Matzke, A.J. and Matzke, M. (2007) RNA-directed DNA methylation mediated by DRD1 and Pol IVb: A versatile pathway for transcriptional gene silencing in plants. Biochim Biophys Acta., 1769, 358-374.
  4. Matzke, M., Kanno, T., Huettel, B., Daxinger, L. and Matzke, A.J. (2006) RNA-directed DNA Methylation and Pol IVb in Arabidopsis. Cold Spring Harb Symp Quant Biol., 71, 449-59.
  5. Mette, M.F., Aufsatz, W., Kanno, T., Daxinger, L., Rovina, P., Matzke, M. and Matzke, A.J. (2005) Analysis of Double-Stranded RNA and Small RNAs Involved in RNA-Mediated Transcriptional Gene Silencing. Methods Mol. Biol., 309, 61-82.
  6. Matzke, M., Gregor, W., Mette, M.F., Aufsatz, W., Kanno, T., Jakowitsch, J. and Matzke, A.J. (2004) Endogenous pararetroviruses of allotetraploid Nicotiana tabacum and its diploid progenitors, N. sylvestris and N. tomentosiformis. Biol. J. Linn. Soc. 82, 627-638.
  7. Matzke, M., Aufsatz, W., Kanno, T., Daxinger, L., Papp, I., Mette, M.F. and Matzke, A.J. (2004) Genetic analysis of RNA-mediated transcriptional gene silencing. Biochim. Biophys. Acta, 1677, 129-141.
  8. Matzke, M.A., Mette, M.F.,Kanno, T., and Matzke, A.J. (2003) Does the intrinsic instability of aneuploid genomes have a causal role in cancer? Trends Genet., 19, 253-256.
  9. Matzke, M.A., Aufsatz, W., Kanno, T., Mette, M.F. and Matzke, A.J. (2002) Homology-dependent gene silencing and host defense in plants. Adv. Genet., 46, 235-275.
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和文総説

  1. Kanno, T. (2008) Link between the SMC hinge domain containing protein and RNA-directed DNA methylation. Cell Technology, 27, 1034-1035 (Mini review).
  2. Kanno, T. (2005) The 4th RNA polymerase and RNA-directed DNA methylation. Cell Technology, 24, 960-961. (Mini review)
  3. Kanno, T. and Habu, Y. (2004) Gene silencing in plants, Epigenetics (Edit. Sasaki, H., Springer Japan), 157-163. (Review)
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発表

  1. Mar. 2004: 45th Annual meeting of the Japanese society of Plant Physiology (Tokyo, Japan; Oral presentation)
  2. Dec. 2003: 26th Annual meeting of the molecular biology society of Japan (Kobe, Japan; Oral presentation)
  3. Jun.-Jul. 2002: 13th International conference on Arabidopsis research (Sevilla, Spain; Poster presentation)
  4. Jun. 2001: 12th International conference on Arabidopsis research (Wisconsin, USA; Poster presentation)
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講演

  1. Sep. 2007: 4th Tri-National Arabidopsis Meeting
    (Vienna, Austria; Invited speaker)
  2. Feb. 2007: The International Conference “Plant Transformation Technologies”
    (Vienna, Austria; Invited speaker)
  3. Aug. 2004: 22nd Annual meeting of Japanese society for plant cell and molecular biology
    (Akita, Japan; Invited speaker)