科学技術振興機構 さきがけ エピジェネティクスの制御と生命機能 エピジェネティクスの制御と生命機能さきがけ独立行政法人科学技術振興機構

研究成果

金田　篤志 （Atsushi Kaneda)

論文

  1. Atsushi Kaneda*, Keisuke Matsusaka, Hiroyuki Aburatani, Masashi Fukayama. Epstein–Barr Virus Infection as an Epigenetic Driver of Tumorigenesis. Cancer Res, published OnlineFirst July 3, 2012.

  2. Koichi Yagi, Hirokazu Takahashi, Kiwamu Akagi, Keisuke Matsusaka, Yasuyuki Seto, Hiroyuki Aburatani, Atsushi Nakajima, Atsushi Kaneda*.Intermediate Methylation Epigenotype and Its Correlation to KRAS Mutation in Conventional Colorectal Adenoma.

    Am J Pathol. epub 23 Nov 2011.
  3. Atsushi Kaneda*, Takanori Fujita, Motonobu Anai, Shogo Yamamoto, Genta Nagae, Masato Morikawa, Shingo Tsuji, Masanobu Oshima, Kohei Miyazono, Hiroyuki Aburatani.Activation of Bmp2-Smad1 signal and its regulation by coordinated alteration of H3K27 trimethylation in Ras-induced senescence.PLoS Genet. 7: e1002359, 2011
  4. Keisuke Matsusaka, Atsushi Kaneda*, Genta Nagae, Tetsuo Ushiku, Yasuko Kikuchi, Rumi Hino, Hiroshi Uozaki, Yasuyuki Seto, Kenzo Takada, Hiroyuki Aburatani, Masashi Fukayama,
    Classification of Epstein-Barr virus positive gastric cancers by definition of DNA methylation Epigenotypes.Cancer Res. Published Online (Oct 11, 2011), doi:10.1158/0008-5472.CAN-11-1349
  5. Atsushi Kaneda*, Koichi Yagi, Two groups of DNA methylation markers to classify colorectal cancer into three epigenotypes;Cancer Science,102:18-24,2011
  6. Deng YB, Nagae G, Midorikawa Y, Yagi K, Tsutsumi S, Yamamoto S, Hasegawa K, Kokudo N, Aburatani H, Kaneda A. Identification of genes preferentially methylated in hepatitis C virus-related hepatocellular carcinoma.,Cancer Sci, 101:1501-10, 2010.

  7. Yagi K, Akagi K, Hayashi H, Nagae G, Tsuji S, Isagawa T, Midorikawa Y, Nishimura Y, Sakamoto H, Seto Y, Aburatani H, Kaneda A. Three DNA methylation epigenotypes in human colorectal cancer.,ClinCancer Res, 16:21-33, 2010.

  8. Kaneda A, Wang CJ, Cheong R, Timp W, Onyango P, Wen B, Iacobuzio-Donahue CA, Ohlsson R, Andraos R, Pearson MA, Sharov AA, Longo DL, Ko MS, Levchenko A, Feinberg AP. Enhanced sensitivity to IGF-II signaling links loss of imprinting of IGF2 to increased cell proliferation and tumor risk. Proc Natl Acad Sci USA 104:20926-31, 2007.
  9. Hayashi H, Nagae G, Tsutsumi S, Kaneshiro K, Kozaki T, Kaneda A, Sugisaki H, Aburatani H. High-Resolution Mapping of DNA Methylation in Human Genome Using Oligonucleotide Tiling Array. Hum Genet, 120: 701-711, 2007.
  10. Maekita T, Nakazawa K, Mihara M, Nakajima T, Yanaoka K, Iguchi M, Arii K, Kaneda A, Tsukamoto T, Tatematsu M, Tamura G, Saito D, Sugimura T, Ichinose M, Ushijima T. High levels of aberrant DNA methylation in Helicobacterpylori-infected gastric mucosae and its possible association with gastric cancer risk. Clin Cancer Res, 12: 989-995, 2006.
  11. Kaneda A, Feinberg AP. Loss of imprinting of IGF2: a common epigenetic modifier of intestinal tumor risk. Cancer Res, 65: 11236-11240, 2005.
  12. Chi XZ, Yang JO, Lee KY, Ito K, Sakakura C, Li QL, Kim HR, Cha EJ, Lee YH, Kaneda A, Ushijima T, Kim WJ, Ito Y, Bae SC. RUNX3 suppresses gastric epithelial cell growth by inducing p21(WAF1/Cip1) expression in cooperation with transforming growth factor β-activated SMAD. Mol Cell Biol, 25: 8097-8107, 2005.
  13. Sakatani T, Kaneda A*, Iacobuzio-Donahue CA, Carter MG, Witzel SD, Okano H, Ko MS, Ohlsson R, Longo DL, Feinberg AP. Loss of imprinting of Igf2 alters intestinal maturation and tumorigenesis in mice. Science, 307: 1976-1978, 2005. (*Equal first author)
  14. Furuta J, Kaneda A, Umebayashi Y, Otsuka F, Sugimura T, and Ushijima T. Silencing of the thrombomodulin gene in human malignant melanoma. Melanoma Res, 15:15-20, 2005.
  15. Abe M, Ohira M, Kaneda A, Yagi Y, Yamamoto S, Kitano Y, Takato T, Nakagawara A, Ushijima T. CpG island methylator phenotype is a strong determinant of poor prognosis in neuroblastomas. Cancer Res, 65: 828-834, 2005.
  16. Ushijima T, Watanabe N, Shimizu K, Miyamoto K, Sugimura T, Kaneda, A. Decreased fidelity in replicating CpG methylation patterns in cancer cells. Cancer Res, 65: 11-17, 2005.
  17. Okochi-Takada E, Ichimura S, Kaneda A, Sugimura T, Ushijima, T. Establishment of a detection system for demethylating agents using an endogenous promoter CpG island. Mutat Res, 568: 187-194, 2004.
  18. Kaneda A, Wakazono K, Tsukamoto T, Watanabe N, Yagi Y, Tatematsu M, Kaminishi M, Sugimura T, Ushijima, T. Lysyl Oxidase is a tumor-suppressor gene inactivated by methylation and loss of heterozygosity in human gastric cancers. Cancer Res, 64: 6410-6415, 2004.
  19. Kaneda A, Kaminishi M, Sugimura T, Ushijima T. Decreased expression of the seven ARP2/3 complex genes in human gastric cancers. Cancer Lett, 212: 203-210, 2004.
  20. Kaneda A, Tsukamoto T, Takamura-Enya T, Watanabe N, Kaminishi M, Sugimura T, Tatematsu M, Ushijima T. Frequent hypomethylation in multiple promoter CpG islands is associated with global hypomethylation, but not with frequent promoter hypermethylation. Cancer Sci, 95: 58-64, 2004.
  21. Ushijima T, Watanabe N, Okochi E, Kaneda A, Sugimura T, Miyamoto K. Fidelity of the methylation pattern and its variation in the genome. Genome Res, 13: 868-874, 2003.
  22. Kaneda A, Takai D, Kaminishi M, Okochi E, Ushijima T. Methylation-sensitive-representational difference analysis and its application to cancer research. Ann N Y Acad Sci, 983: 131-141, 2003.
  23. Kaneda A, Kaminishi M, Yanagihara K, Sugimura T, Ushijima, T. Identification of silencing of nine genes in human gastric cancers. Cancer Res, 62: 6645-6650, 2002.
  24. Abe M, Okochi E, Kuramoto T, Kaneda A, Takato T, Sugimura T, Ushijima T. Cloning of the 5' Upstream Region of the Rat p16 Gene and Its Role in Silencing. Jpn J Cancer Res, 93: 1100-1106, 2002.
  25. Kaneda A, Kaminishi M, Nakanishi Y, Sugimura T, Ushijima T. Reduced expression of the insulin-induced protein 1 and p41 Arp2/3 complex genes in human gastric cancers. Int J Cancer, 100: 57-62, 2002.
  26. Li QL, Ito K, Sakakura C, Fukamachi H, Inoue K, Chi XZ, Lee KY, Nomura S, Lee CW, Han SB, Kim HM, Kim WJ, Yamamoto H, Yamashita N, Yano T, Ikeda T, Itohara S, Inazawa J, Abe T, Hagiwara A, Yamagishi H, Ooe A, Kaneda A, Sugimura T, Ushijima T, Bae SC, Ito Y. Causal relationship between the loss of RUNX3 expression and gastric cancer. Cell, 109: 113-124, 2002.
  27. McKenzie AN, Li X, Largaespada DA, Sato A, Kaneda A, Zurawski SM, Doyle EL, Milatovich A, Francke U, Copeland NG, Jenkins NA, Zurawski G. Structural comparison and chromosomal localization of the human and mouse IL-13 genes. J Immunol, 150: 5436-5444, 1993.