科学技術振興機構 さきがけ エピジェネティクスの制御と生命機能 エピジェネティクスの制御と生命機能さきがけ独立行政法人科学技術振興機構

研究成果

堀　哲也 （Tetsuya Hori)

原著欧文論文

  1. Wei-Hao Shang1, Tetsuya Hori1（同等筆頭著者）, Nuno M.C. Martins2, Atsushi Toyoda3, Sadahiko Misu4, Norikazu Monma4, Ichiro Hiratani5, Kazuhiro Maeshima5,Kazuho Ikeo4, Asao Fujiyama3, 6, Hiroshi Kimur"Chromosome engineering allows the efficient isolation of vertebrate neocentromeres"Developmental Cell DOI.org/10.1016/j.devcel2013.02.009
  2. Tetsuya Hori, Wei-Hao hang, Kozo Takeuchi、 and Tatsuo Fukagawa”The CCAN recruits CENP-A to the centromere and forms the structural core for kinetochore assembly”J. Cell Biol　DOI 10.1083/jcb.201210106
  3. Tetsuya Hori & Tatsuo Fukagawa,"Establishment of the vertebrate kinetochores"

    Chromosome Res.DOI 10.1007/s10577-012-9289-9

  4. Suzuki, A., Hori, T., Nishino, T., Usukura, J., Miyagi, A., Morikawa, K., and Fukagawa, T.“Spindle microtubules generate tension-dependent changes in the distribution of inner kinetochore proteins.”J. Cell. Biol.,193,125-140:2011.
  5. Schmidt, J.C., Kiyomitsu, T., Hori, T., Backer, C.B., Fukagawa, T., Cheeseman, I.M.“Aurora B kinase controls the targeting of the Astrin-SKAP complex to bioriented kinetochores.”J. Cell. Biol., 2010, 191(2), 269-280.
  6. Shang, W.H., Hori, T., Toyoda, A., Kato, J., Popendorf, K., Sakakibara, Y., Fujiyama, A., Fukagawa, T. Chickens possess centromeres with both extended tandem repeats and short non-tandem-repetitive sequences. Genome Res., 20(9), 1219-1228. (2010)3.
  7. Johnston, K., Joglekar, A., Hori, T., Suzuki, A., Fukagawa, T., Salmon, E.D. Vertebrate kinetochore protein architecture: protein copy number. J. Cell Biol., 189(6), 937-943. (2010)
  8. Ribeiro, S.A., Vagnarelli, P., Dong, Y., Hori, T., McEwen, B.F., Fukagawa, T., Flors, C., Earnshaw, W.C. A super-resolution map of the vertebrate kinetochore. Proc. Natl. Acad. Sci. USA., 107(23), 10484-10489. (2010)
  9. Matsuda, R., Hori, T., Kitamura, H., Takeuchi, K., Fukagawa, T., Harata, M. Identification and characterization of the two isoforms of the vertebrate H2A.Z histone variant. Nucleic Acids Res., 38(13), 4263-4273. (2010)
  10. Liu, D., Vleugel, M., Backer, C.B., Hori, T., Fukagawa, T., Cheeseman, I.M., Lampson, M.A. Regulated targeting of protein phosphatase 1 to the outer kinetochore by KNL1 opposes Aurora B kinase. J. Cell Biol., 188(6), 809-820. (2010)
  11. Kawashima, T., Bao, Y.C., Minoshima, Y., Nomura, Y., Hatori, T., Hori, T., Fukagawa, T., Fukada, T., Takahashi, N., Nosaka, T., Inoue, M., Sato, T., Kukimoto-Niino, M., Shirouzu, M., Yokoyama, S., Kitamura, T. A Rac GTPase-activating protein, MgcRacGAP, is a nuclear localizing signal-containing nuclear chaperone in the activation of STAT transcription factors. Mol. Cell. Biol., 29(7), 1796-1813. (2009)
  12. Iwamoto, M., Mori, C., Kojidani, T., Bunai, F., Hori, T., Fukagawa, T., Hiraoka, Y., Haraguchi, T. Two distinct repeat sequences of Nup98 nucleoporins characterize dual nuclei in the binucleated ciliate tetrahymena. Curr. Biol., 19(10), 843-847. (2009)
  13. Amano, M., Suzuki, A., Hori, T., Backer, C., Okawa, K., Cheeseman, I.M., Fukagawa, T. The CENP-S complex is essential for the stable assembly of outer kinetochore structure. J. Cell Biol., 186(2), 173-182. (2009)
  14. Hori, T., Amano, M., Suzuki, A., Backer, C.B., Welburn, J.P., Dong, Y., McEwen, B.F., Shang, W.H., Suzuki, E., Okawa, K., Cheeseman, I.M., Fukagawa, T. CCAN makes multiple contacts with centromeric DNA to provide distinct pathways to the outer kinetochore. Cell, 135(6), 1039-1052. (2008)
  15. Hori, T., Okada, M., Maenaka, K., Fukagawa, T. CENP-O Class Proteins Form a Stable Complex and Are Required for Proper Kinetochore Function. Mol. Biol. Cell, 19(3), 843-854. (2008)
  16. Cheeseman, I.M., Hori, T., Fukagawa, T., Desai, A. KNL1 and the CENP-H/I/K Complex Coordinately Direct Kinetochore Assembly in Vertebrates. Mol. Biol. Cell, 19(2), 587-594. (2008)
  17. Kwon, M.S., Hori, T., Okada, M., Fukagawa, T. CENP-C is involved in chromosome segregation, mitotic checkpoint function, and kinetochore assembly. Mol. Biol. Cell, 18(6), 2155-2168. (2007)
  18. Kimura, H., Takizawa, N., Allemand, E., Hori, T., Iborra, F.J,, Nozaki, N., Muraki, M., Hagiwara, M., Krainer, A.R., Fukagawa, T., Okawa, K. A novel histone exchange factor, protein phosphatase 2Cgamma, mediates the exchange and dephosphorylation of H2A-H2B. J. Cell Biol., 175(3), 389-400. (2006)
  19. Kline, S.L., Cheeseman, I.M., Hori, T., Fukagawa, T., Desai, A. The human Mis12 complex is required for kinetochore assembly and proper chromosome segregation. J. Cell Biol., 173(1), 9-17. (2006)
  20. Okada, M., Cheeseman, I.M., Hori, T., Okawa, K., McLeod, I.X., Yates, J.R. 3rd, Desai, A., Fukagawa, T. The CENP-H-I complex is required for the efficient incorporation of newly synthesized CENP-A into centromeres. Nature Cell Biology, 8(5), 446-457. (2006)
  21. Moriyama, S., Ogihara, J., Kato, J., Hori, T., Mizuno, S. PKCI-W forms a heterodimer with PKCI-Z and inhibits the biological activities of PKCI-Z in vitro, supporting the predicted role of PKCI-W in sex determination in birds. J. Biochem., 139(1), 91-97. (2006)
  22. Minoshima, Y., Hori, T., Okada, M., Kimura, H., Haraguchi, T., Hiraoka, Y., Bao, Y.C., Kawashima, T., Kitamura, T., Fukagawa, T. The constitutive centromere component CENP-50 is required for recovery from spindle damage. Mol. Cell. Biol., 25(23), 10315-10328. (2005)
  23. Mikami, Y., Hori, T., Kimura, H., Fukagawa, T. The functional region of CENP-H interacts with the Nuf2 complex that localizes to centromere during mitosis. Mol. Cell. Biol., 25(5), 1958-1970. (2005)
  24. Yokomine, T., Shirohzu, H., Purbowasito, W., Toyoda, A., Iwama, H., Ikeo, K., Hori, T., Mizuno, S., Tsudzuki, M., Matsuda, Y., Hattori, M., Sakaki, Y., Sasaki, H. Structural and functional analysis of a 0.5-Mb chicken region orthologous to the imprinted mammalian Ascl2/Mash2-Igf2-H19 region. Genome Res., 15(1), 154-165. (2005)
  25. Hori, T., Haraguchi, T., Hiraoka, Y., Kimura, H., Fukagawa, T. Dynamic behavior of Nuf2-Hec1 complex that localizes to the centrosome and centromere and is essential for mitotic progression in vertebrate cells. J. Cell Sci., 116, 3347-3362. (2003)
  26. Kato, J., Hattori, T., Ohba, S., Tamaki, Y., Yamada, N., Taguchi, T., Ogihara, J., Ohya, K., Itoh, Y., Hori, T., Asakawa, S., Shimizu, N., Mizuno, S. Efficient selection of genomic clones from a female chicken bacterial artificial chromosome library by four-dimensional polymerase chain reactions. Poultly Science, 81(10), 1501-1508. (2002)
  27. Kuroda, Y., Arai, N., Arita, M., Teranisi, M., Hori, T., Harata, M., Mizuno, S. Absence of Z-chromosome inactivation for five genes in male chickens. Chromosome Res., 9, 457-468. (2001)
  28. Itoh, Y., Hori, T., Saitoh, H. and Mizuno, S. Chicken spindlin genes on W and Z chromosomes: transcriptional expression of both genes and dynamic behavior of spindlin in interphase and mitotic cells. Chromosome Res., 9, 283-299. (2001)
  29. Teranishi, M., Shimada, Y., Hori, T., Nakabayashi, O., Kikuchi, T., Macleod, T., Pym, R., Sheldon, B., Solovei, I., Macgregor, H. and　Mizuno, S. Transcripts of the MHM region on the chicken Z chromosome accumulate as non-coding RNA in the nucleus of female cells adjacent to the DMRT1 locus. Chromosome Res., 9, 147-165. (2001)
  30. Tateda, M., Shiga, K., Saijo, S., Sone, M., Hori, T., Yokoyama, J., Matsuura, K., Takasaka, T. and Miyagi, T. Streptococcus anginosus in head and neck spuamous cell carcinoma: implication in carcinogenesis. International Journal of Molecular Medicine, 6, 699-703. (2000)
  31. Hori, T., Asakawa, S., Itoh, Y., Shimizu, N. and Mizuno, S. Wpkci, Encoding an Altered Form of PKCI, Is Conserved Widely on the Avian W Chromosome and Expressed in Early Female Embryos: Implication of Its Role in Female Sex Determination. Mol. Biol. Cell, 11, 3645-3660. (2000)
  32. Solovei, I. V., Joffe, B. I., Hori, T., Thomson, P., Mizuno, S., Macgregor, H. C. Unordered arrangement of chromosomes in the nuclei of chicken spermatozoa. Chromosoma, 107, 184-188. (1998)
  33. Hori, T., Suzuki, Y., Solovei, I., Saitoh, Y., Hutchison, N., Ikeda, J., Macgregor, H. and Mizuno, S. Characterization of DNA sequences constituting the terminal heterochromatin of the chicken Z chromosome. Chromosome Res., 4, 411-426. (1996)
  34. Saitoh, Y., Ogawa, A., Hori, T., Kunita, R., Mizuno, S. Identification and localization of two genes on the chicken Z chromosome: implication of evolutionary conservation of the Z chromosome among avian species. Chromosome Res., 1, 239-251. (1993)
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欧文総説

  1. Hori, T., Okada, M., and Fukagawa, T.
    Molecular mechanism for kinetochore assembly in vertebrate cells.
    DNA structure, Chromatin and Gene Expression.
    Transworld Research Network, 37/661 (2), 237-252. (2006)
  2. Okada, M., Hori, T., and Fukagawa, T.
    The DT40 system as a tool for analyzing kinetochore assembly.
    Reviews and protocols in DT40 Research.
    Subcellular Biochemistry, 40, 91-106. (2006)
  3. Mizuno, S., Kunita, R., Nakabayashi, O., Kuroda, Y., Arai, N., Harata, M., Ogawa, A., Itoh, Y., Teranishi, M. and Hori, T.
    Z and W chromosomes of chickens : studies on their gene functions in sex deteremination and sex differentiation.
    Cytogenet. Genome Res., 99, 236-244. (2002)
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和文総説

  1. 堀　哲也、深川　竜郎
    セントロメアでのクロマチン構造の形成に必要なヒストンバリアントとDNA結合タンパク質
    蛋白質　核酸　酵素, 54(10), 1276-1283. (2009)
  2. 堀　哲也、深川　竜郎
    セントロメアクロマチン上に集合するキネトコアタンパク質のダイナミクス
    蛋白質　核酸　酵素, 51(4), 326-334. (2006)
  3. 堀　哲也
    染色体の構築と分配
    細胞核の分子生物学, -クロマチン・染色体・核構造- 朝倉書店, 87-131. (2005)