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JST Press Release

May 10, 2017
Japan Science and Technology Agency (JST)
5-3, Yonbancho, Chiyoda-ku, Tokyo 102-8666

Development of sponge-type artificial scaffolds attracting new blood vessels in the ischemic brain

The first step for injured brain regeneration

Neovascularization from existing blood vessels, which is called angiogenesis, is essential for tissue growth and repair. Proangiogenic therapies for brain stroke can potentially prevent excess neuron death and improve functional recovery. The laminin-sponge with affinity-immobilized vascular endothelial growth factor, which is an angiogenic growth factor, is reported. The angiogenic activity of this sponge in vivo in a mouse stroke model is demonstrated.

Program Information

Research Area “Molecular technology and creation of new functions”
Research Theme “Development of brain regeneration device using artificial protein activated under hypoxia”

Journal Information

Oshikawa M, Okada K, Kaneko N, Sawamoto K, and Ajioka I. “Affinity-Immobilization of VEGF on Laminin Porous Sponge Enhances Angiogenesis in the Ischemic Brain”. Advanced Healthcare Materials, Published online May 10, 2017, doi: 10.1002/adhm.201700183


[About Research]
Itsuki Ajioka, Ph.D.
Associate professor, Center for Brain Integration Research (CBIR), Tokyo Medical and Dental University (TMDU)
URL: http://www.tmd.ac.jp/cbir/1/ajioka/english/index.html

[About Program]
Tsuyoshi Nakamura
Green Innovation Group, Department of Innovation Research, JST


JST, an integrated organization of science and technology in Japan, establishes an infrastructure for the entire process from the creation of knowledge to the return to the society. For more information, visit http://www.jst.go.jp/EN/