- Depletion of CD169+ macrophages suppresses DSS-induced colitis in mice.
- Monocyte infiltration, but not neutrophils or eosinophils, was reduced in the absence of CD169+ macrophages.
- CCL8 is produced exclusively by CD169+ macrophages in the colon.
- Administration of anti-CCL8 antibody ameliorates the clinical symptoms of DSS-induced colitis.
Researcher Information
JST PRESTO
Research Area “ Elucidation and control of the mechanisms underlying chronic inflammation”
Research Theme “ Development of Sentinel Cell-targeted Therapy for Inflammatory Bowel Diseases”
Journal Information
Authors: Kenichi Asano, Naomichi Takahashi, Mikiko Ushiki, Misa Monya, Fumiaki Aihara, Erika Kuboki, Shigetaka Moriyama, Mayumi Iida, Hiroshi Kitamura, Chun-Hong Qiu, Takashi Watanabe, and Masato Tanaka. “Intestinal CD169+ macrophages initiate mucosal inflammation by secreting CCL8 that recruits inflammatory monocytes”. Nature Communications, Published online 21 July 2015, doi: 10.1038/ncomms8802.
Contact
[About Research]
Kenichi Asano, M.D., Ph.D.
Associate Professor, Laboratory of Immune Regulation, School of Life Science, Tokyo University of Pharmacy and Life Sciences
E-mail: 
URL: http://toyaku-ls-immune.com/en/index.html
[About Program]
Koji Matsuo, Tetsu Kawaguchi, and Shinichi Kato
Life Innovation Group, Department of Innovation Research, JST
E-mail: 