Research Site : Assistant Professor, Graduate School of Life and Environmental Sciences, University of Tsukuba
Abstract
In eukaryotes, genomic DNA is assembled into the higher-order structure termed "chromosome" and then is stored in the nucleus. Proper chromosome segregation during both mitosis and meiosis is essential to maintain the integrity of the genome and to transmit genetic information. Previous studies have suggested unexpected roles of non-coding RNAs/RNA-binding proteins in chromosome segregation. In this project, I will reveal the mechanism(s) by which non-coding RNA/RNA-binding proteins regulate chromosome segregation.
