Deciphering cellular codes of alternative pre-mRNA processing.
Research Site : Associate Professor, School of Biomedical Science, Tokyo Medical and Dental University
Abstract
Complex multicellular organisms generate a diverse set of proteins to set the form and function of specialized cell types from a limited number of protein-coding genes through the process of alternative pre-mRNA processing. However, trans-acting regulators and cis-elements required for the cell-type-specific patterns of alternative mRNA processing in vivo, or cellular codes, remain largely unknown. In this project, the principal investigator tries to decipher the "cellular codes"of alternative pre-mRNA processing by applying a new technology of visualizing alternative processing patterns in living organisms established by himself.
