Analysis of molecular basis for non-self RNA recognition by intracellular virus sensors
Research Site : Professor, Molecular Immunology, Medical Mycology Research Center, Chiba University
Abstract
To understand viral infectious diseases, it is important to elucidate relationship between viral expansion and host defense mechanisms. Recent advances in cytoplasmic virus-sensors, which detect viral RNA as 'non-self', highlight their essential role in the induction of antiviral innate immunity. In this project, I focus on how host cells sense viral RNA and initiate self-defense system.
