Gene expression regulation via RNA surveillance mechanism
Research Site : Assistant Professor , Department of Microbiology and Molecular Biodefense Research (Yokohama City University)
Abstract
Eukaryotes have evolutionally conserved mRNA surveillance mechanism that detects and degrades mRNA containing premature termination codons (PTC) to eliminate potentially harmful C-terminally truncated proteins which can have gain-of-function and dominant-negative effects. This project addresses the development of new methods which isolate and detect PTC-containing mRNAs. These technologies will be the basic technology for the diagnosis and treatment for various genetic diseases and cancers.
