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Kazuhiro Aoki
Lecturer, Graduate School of Biostudies, Kyoto University
Quantitative modeling of cellular signal transduction
Recent advances in molecular and computational biology have made possible the study of intricate
cellular signaling networks described as a function of kinetic reactions. However, it is well recognized
the difficulty in developing kinetic models of signal transduction networks due to lack of quantitative
kinetic parameters. To overcome this problem, in this study, I quantitatively obtain spatio-temporal
kinetic parameters by using a leading-edge microscopic technology. Furthermore, with the experimentally
-determined kinetic parameters, I build and analyze the kinetic model that accounts for a process of
tumorigenesis. These approaches should allow us to elucidate complete codes of regulatory signaling
networks for tumorigenesis.