Pathophysiological analysis of receptor-activity-modifying protein and development of a new therapy for vascular diseases
Adrenomedullin (AM) is a peptide, which possess various biological activities, including organ-protective effects, and anti-atherosclerotic effects. These biological activities of AM are controlled by receptor-activity-modifying proteins (RAMPs). In this study, I will clarify the pathophysiological roles of AM-RAMP system by using a series of genetically-engineered mice and aim at development of a new therapy for metabolic syndrome and vascular diseases.