Professor, Division of Membrane Physiology, Department of Cell Physiology, National Institute for Physiological Sciences, National Institutes of Natural Sciences
Spatio-templral analysis of dynamic S-acylation on synaptic function
Posttranslational modification, including phosphorylation and lipid modification, provides proteins with additional function and regulatory systems beyond genomic information, allowing cells to maintain homeostasis and respond to extracellular signals. In particular, reversible S-acylation -the common lipid modification- regulates protein trafficking and function. However, the molecular mechanisms of S-acylation have been elusive. The objective of this project is to understand how protein S-acylation is regulated by specific extracellular signals. I will develop novel methods to monitor protein S-acylation and clarify the whole picture of S-acylation. This work should open the new dimension of regulatory mechanism underlying complex physiological function like synaptic plasticity.
