Japan Science and Technology Agency. Metabolism and cellular Function PRESTO
Japanese English Japan Science and Technology Agency. PRESTO
Resercher, Research Theme
Ikuro Abe
Phase I (2005-2008)
Photo
Research Site
Professor, Graduate School of Pharmaceutical Sciences, The University of Tokyo
Research Reports
http://www.metabolism.jst.go.jp/en/ronbun/abe.html
Theme
Engineered Biosynthesis of Secondary Metabolites
Abstract
Manipulation of key enzymes responsible for generating basic skeletons of pharmaceutically important secondary metabolites (e.g. polyketides and isoprenoids) leads to production of biologically active, supra-natural products with remarkable structural diversity. Two specific aims of the proposed research are (1) structure-based rational design of mutant enzymes of plant polyketide synthases and squalene cyclases with altered substrate and product specificities, and (2) exploration of catalytic potential of the enzymes by using synthetic substrate analogs.


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