 |
Adopted FY2005 Shuji OGATA Atushi OSHIYAMA Masaki SATOH Toshikazu TAKADA Keiko TAKAHASHI Seiichiro TEN-NO Kimihiko HIRAO Mitsuhiro MATSU'URA Adopted FY2006 Masataka NAGAOKA Hiroyasu HASUMI Masahiko MACHIDA Masuhiro MIKAMI Keiji MOROKUMA Yasuhiro YAMANAKA Ryoichi YAMAMOTO Adopted FY2007 Yuriko AOKI Masatoshi IMADA Hideyuki USUI Akio KITAO Hiroshi NAKATSUJI Shinobu YOSHIMURA |
Research Directors / Research Themes Research and Development of DDS Simulator
Osamu SANO Professor,Institute of Symbiotic Science and Technology, Satoshi ITOH Chief Research Scientist,Corporate Research & Development Cener,TOSHIBA CORPORATION
In this research project, we will develop a multi-scale simulation methodology for active targeting drug delivery system (DDS) consisting of a liposome and sugar chain. This simulation methodology based on the fragment molecular orbital method, molecular simulation and fluid dynamics enables us to do (1)design of DDS nanoparticle, (2)analysis of molecular interaction between lectin protein and sugar chain, and (3)flow analysis of DDS nanoparticles in a blood vessel, which are essential for the DDS development. Also, we will provide the basis for a general DDS design by developing DDS simulator which integrates these simulation methodologies.
|
