本文へジャンプ
迫野 昌文
(SAKONO Masafumi)

出身地
福岡県

略 歴
1999年
九州大学工学部応用化学科 卒業
2001年
九州大学大学院工学研究院 博士前期課程修了
(システム工学専攻: 古崎新太郎教授)
2004年
九州大学大学院工学研究院 博士後期課程修了
(システム工学専攻: 後藤雅宏教授)
2004年
工学博士取得
2001-4年
日本学術振興会 特別研究員(DC1)
2004‐6年
(独)理化学研究所 基礎科学特別研究員
(前田バイオ工学研究室)
2006‐10年
(独)科学技術振興機構 “構造機能と計測分析”領域 研究者
2010年‐
(独)科学技術振興機構 ERATO 伊藤グライコトリロジープロジェクト 研究員
2011年‐
国際基督教大学 非常勤講師
(担当科目: Biochemistry I, Biochemistry II)
2012年-
文部科学省 科学技術政策研究所 科学技術動向研究センター 専門調査員

所属学会
化学工学会生物工学会、日本化学会、分子科学会、高分子学会、アメリカ化学会

近年の論文
  1. Masafumi Sakono, Tamotsu Zako, Hiroshi Ueda, Masafumi Yohda, Mizuo Maeda:

    Formation of highly toxic soluble amyloid beta oligomers by the molecular chaperone prefoldin.

    FEBS Journal, 275 (2008) 5982-93.
  2. Tamotsu Zako, Hiroyasu Nagata, Naofumi Terada, Masafumi Sakono, Kohei Soga, Mizuo Maeda:

    Improvement of dispersion stability and characterization of upconversion nanophosphors covalently modified with PEG as a fluorescence bioimaging probe.

    Journal of Materials Science, 43 (2008) 5325-30.
  3. Jun Okada, Tatsuo Maruyama, Konomi Motomura, Kimiko Kuroki, Katsumi Maenaka, Masafumi Sakono, Masahiro Goto:

    Enzyme-mediated protein refolding.

    Chemical Communications, (2009) 7197-99.
  4. Tamotsu Zako, Masafumi Sakono, Naomi Hashimoto, Masaki Ihara, Mizuo Maeda:

    Bovine insulin filaments induced by reducing disulfide bonds show a different morphology, secondary structure, and cell toxicity from intact insulin amyloid fibrils.

    Biophysical Journal, 96 (2009) 3331-40.
  5. Tamotsu Zako, Hiroyasu Nagata, Naofumi Terada, Arata Utsumi, Masafumi Sakono, Masafumi Yohda, Hiroshi Ueda, Kohei Soga, Mizuo Maeda:

    Cyclic RGD peptide-labeled upconversion nanophosphors for tumor cell-targeted imaging.

    Biochemical and Biophysical Research Communications, 381 (2009) 54-58.
  6. Masafumi Sakono and Tamotsu Zako:

    Amyloid oligomers: formation and toxicity of Abeta oligomers.

    FEBS Journal, 277 (2010) 1348-58.
  7. Tamotsu Zako, Shinya Banba, Muhamad Sahlan, Masafumi Sakono, Naofumi Terada, Masafumi Yohda, Mizuo Maeda:

    Hyperthermophilic archaeal prefoldin shows refolding activity at low temperature.

    Biochemical and Biophysical Research Communications, 391 (2010) 467-470.
  8. Kazuki Bando, Tamotsu Zako, Masafumi Sakono, Mizuo Maeda, Takehiko Wada, Masaki Nishijima, Gaku Fukuhara, Cheng Yang, Tadashi Mori, Tamara C. S. Pace, Cornelia Bohne and Yoshihisa Inoue:

    Bio-supramolecular photochirogenesis with molecular chaperone: enantiodifferentiating photocyclodimerization of 2-anthracenecarboxylate mediated by prefoldin.

    Photochemical and Photobiological Sciences 9 (2010) 655-660.
  9. Masafumi Sakono, Tamotsu Zako, Srdja Drakulic, José M Valpuesta, Masafumi Yohda, Mizuo Maeda:

    Size-selective recognition of gold nanoparticles by a molecular chaperone.

    Chemical Physics Letters, 501 (2010) 108-112.
  10. Masafumi Sakono, Konomi Motomura, Tatsuo Maruyama, Noriho Kamiya, Masahiro Goto:

    Alpha casein micelles show not only molecular chaperone-like aggregation inhibition properties but also protein refolding activity from the denatured state.

    Biochemical and Biophysical Research Communications, 404 (2011) 494-497.
  11. Masafumi Sakono, Shigenori Akiyama, Tamotsu Zako, Shujiro Sakaki, Tomonori Waku, Naoki Tanaka, Mizuo Maeda:

    Application of two morphologically different fibrillar and filamentous insulin amyloids as a biomaterial for cell culture surfaces.

    Reactive and Functional Polymers, 71 (2011) 324-328.
  12. Masafumi Sakono, Shigenori Akiyama, Tamotsu Zako, Shujiro Sakaki, Tomonori Waku, Naoki Tanaka, Mizuo Maeda:

    Immobilized insulin amyloid enhances cell adhesion and proliferation due to interaction with fibronectin.

    Chemistry Letters, 40 (2011) 315-317.
  13. Masafumi Sakono, Tamotsu Zako, and Mizuo Maeda:

    Naked-eye detection of amyloid aggregates by gold nanoparticles conjugated with amyloid beta antibody.

    Analytical Sciences, 28 (2012) 73-76.
  14. Masafumi Sakono, Tamotsu Zako, Masafumi Yohda and Mizuo Maeda:

    Amyloid oligomer detection by immobilized molecular chaperone.

    Biochemical Engineering Journal, 61 (2012) 28-33.
  15. Tomohiro Hiraishi, Koichi Yamashita, Masafumi Sakono, Jun Nakanishi, Tan Liu Tzea, Kumar Sudesh, Hideki Abe, and Mizuo Maeda:

    Cell Surface Display of Functionally Active PHB Depolymerase on Escherichia coli.

    Macromolecular Bioscience, 12 (2012) 218-224. (Selected as Cover picture)
  16. Tamotsu Zako, Masafumi Sakono, Takahiro Kobayashi, Karin Sörgjerd, K.
    Peter R. Nilsson, Per Hammarström, Mikael Lindgren, and Mizuo Maeda:
    Cell interaction study of amyloid using luminescent conjugated
    polythiophene: Implication that amyloid cytotoxicity is correlated with prolonged cellular binding.
    ChemBioChem, 13 (2012) 358-363.
  17. Masayuki Izumi, Yutaka Makimura, Simone Dedola, Akira Seko, Akiko Kanamori, Masafumi Sakono, Yukishige Ito, and Yasuhiro Kajihara:
    Chemical Synthesis of Intentionally Misfolded Homogeneous Glycoprotein: A Unique Approach for the Study of Glycoprotein Quality Control.
    Journal of the American Chemical Society, 134 (2012) 7238-7241.
  18. Masafumi Sakono, Akira Seko, Yoichi Takeda, Masakazu Hachisu, and Yukishige Ito:
    Biophysical properties of UDP-glucose:glycoprotein glucosyltransferase, a folding sensor enzyme in the ER, delineated by synthetic probes.
    Biochemical and Biophysical Research Communications, 426 (2012) 504-510.
  19. Masafumi Sakono, Arata Utsumi, Tamotsu Zako, Tetsuya Abe, Masafumi Yohda and Mizuo Maeda:
    Formation of non-toxic Aβ fibrils by small heat shock protein under heat-stress conditions.
    Biochemical and Biophysical Research Communications, 430 (2013) 1259-1264.
  20. Karin Margareta Sörgjerd, Tamotsu Zako, Masafumi Sakono, Peter C. Stirling, Michel R. Leroux, Takashi Saito, Per Nilsson, Misaki Sekimoto, Takaomi C. Saido, and Mizuo Maeda:
    Human Prefoldin Inhibits Amyloid-β (Aβ) Fibrillation and Contributes to Formation of Nontoxic Aβ Aggregates.
    Biochemistry, 52 (2013) 3532-3542.
  21. Yoichi Takeda, Akira Seko, Masafumi Sakono, Masakazu Hachisu, Akihiko Koizumi, Kohki Fujikawa, Yukishige Ito:
    Parallel quantification of lectin–glycan interaction using ultrafiltration.
    Carbohydrate Research, 375 (2013) 112-117.
  22. Simone Dedola, Masayuki Izumi, Yutaka Makimura, Akira Seko, Akiko Kanamori, Masafumi Sakono, Yukishige Ito, Yasuhiro Kajihara:
    Folding of Synthetic Homogeneous Glycoproteins in the Presence of a Glycoprotein Folding Sensor Enzyme
    Angewandte Chemie International Edition, 53 (2014) 2883-2887.
  23. Masafumi Sakono, Akira Seko, Yoichi Takeda, Jun-ichi Aikawa, Masakazu Hachisu, Akihiko Koizumi, Kohki Fujikawa, Yukishige Ito:
    Glycan specificity of a testis-specific lectin chaperone calmegin and effects of hydrophobic interactions
    Biochimica et Biophysica Acta (BBA) - General Subjects, 1840 (2014) 2904-2913.
  24. Masafumi Sakono, Akira Seko, Yoichi Takeda, Yukishige Ito:
    PDI family protein ERp29 forms 1:1 complex with lectin chaperone calreticulin
    Biochemical and Biophysical Research Communications, (2014) in press
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