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- 1999年
- 九州大学工学部応用化学科 卒業
- 2001年
- 九州大学大学院工学研究院 博士前期課程修了
(システム工学専攻: 古崎新太郎教授)
- 2004年
- 九州大学大学院工学研究院 博士後期課程修了
(システム工学専攻: 後藤雅宏教授)
- 2004年
- 工学博士取得
- 2001-4年
- 日本学術振興会 特別研究員(DC1)
- 2004‐6年
- (独)理化学研究所 基礎科学特別研究員
(前田バイオ工学研究室)
- 2006‐10年
- (独)科学技術振興機構 “構造機能と計測分析”領域 研究者
- 2010年‐
- (独)科学技術振興機構 ERATO 伊藤グライコトリロジープロジェクト 研究員
- 2011年‐
- 国際基督教大学 非常勤講師
(担当科目: Biochemistry I, Biochemistry II)
- 2012年-
- 文部科学省 科学技術政策研究所 科学技術動向研究センター 専門調査員
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化学工学会、生物工学会、日本化学会、分子科学会、高分子学会、アメリカ化学会
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Masafumi Sakono, Tamotsu
Zako, Hiroshi Ueda, Masafumi Yohda, Mizuo Maeda:
Formation of highly toxic soluble
amyloid beta oligomers by the molecular chaperone prefoldin.
FEBS Journal, 275 (2008) 5982-93.
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Tamotsu Zako, Hiroyasu Nagata,
Naofumi Terada, Masafumi Sakono, Kohei Soga, Mizuo Maeda:
Improvement of dispersion
stability and characterization of upconversion nanophosphors covalently
modified with PEG as a fluorescence bioimaging probe.
Journal of Materials Science, 43 (2008) 5325-30.
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Jun Okada, Tatsuo Maruyama, Konomi
Motomura, Kimiko Kuroki, Katsumi Maenaka, Masafumi Sakono, Masahiro
Goto:
Enzyme-mediated protein refolding.
Chemical Communications, (2009) 7197-99.
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Tamotsu Zako, Masafumi Sakono,
Naomi Hashimoto, Masaki Ihara, Mizuo Maeda:
Bovine insulin filaments induced
by reducing disulfide bonds show a different morphology, secondary structure,
and cell toxicity from intact insulin amyloid fibrils.
Biophysical Journal, 96 (2009) 3331-40.
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Tamotsu Zako, Hiroyasu Nagata,
Naofumi Terada, Arata Utsumi, Masafumi Sakono, Masafumi Yohda, Hiroshi
Ueda, Kohei Soga, Mizuo Maeda:
Cyclic RGD peptide-labeled
upconversion nanophosphors for tumor cell-targeted imaging.
Biochemical and Biophysical Research Communications, 381 (2009) 54-58.
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Masafumi Sakono and
Tamotsu Zako:
Amyloid oligomers: formation and
toxicity of Abeta oligomers.
FEBS Journal, 277 (2010) 1348-58.
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Tamotsu Zako, Shinya Banba,
Muhamad Sahlan, Masafumi Sakono, Naofumi Terada, Masafumi Yohda, Mizuo
Maeda:
Hyperthermophilic archaeal
prefoldin shows refolding activity at low temperature.
Biochemical and Biophysical Research Communications, 391 (2010) 467-470.
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Kazuki Bando, Tamotsu Zako, Masafumi
Sakono, Mizuo Maeda, Takehiko Wada, Masaki Nishijima, Gaku Fukuhara, Cheng
Yang, Tadashi Mori, Tamara C. S. Pace, Cornelia Bohne and Yoshihisa Inoue:
Bio-supramolecular
photochirogenesis with molecular chaperone: enantiodifferentiating
photocyclodimerization of 2-anthracenecarboxylate mediated by prefoldin.
Photochemical and Photobiological Sciences 9 (2010) 655-660.
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Masafumi Sakono, Tamotsu
Zako, Srdja Drakulic, José M Valpuesta, Masafumi Yohda, Mizuo Maeda:
Size-selective recognition of gold
nanoparticles by a molecular chaperone.
Chemical Physics Letters, 501 (2010) 108-112.
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Masafumi Sakono, Konomi
Motomura, Tatsuo Maruyama, Noriho Kamiya, Masahiro Goto:
Alpha casein micelles show not
only molecular chaperone-like aggregation inhibition properties but also
protein refolding activity from the denatured state.
Biochemical and Biophysical Research Communications, 404 (2011) 494-497.
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Masafumi Sakono, Shigenori
Akiyama, Tamotsu Zako, Shujiro Sakaki, Tomonori Waku, Naoki Tanaka, Mizuo
Maeda:
Application of two morphologically
different fibrillar and filamentous insulin amyloids as a biomaterial for cell
culture surfaces.
Reactive and Functional Polymers, 71 (2011) 324-328.
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Masafumi Sakono,
Shigenori Akiyama, Tamotsu Zako, Shujiro Sakaki, Tomonori Waku, Naoki Tanaka,
Mizuo Maeda:
Immobilized insulin amyloid
enhances cell adhesion and proliferation due to interaction with fibronectin.
Chemistry Letters, 40 (2011) 315-317.
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Masafumi Sakono, Tamotsu
Zako, and Mizuo Maeda:
Naked-eye detection of amyloid
aggregates by gold nanoparticles conjugated with amyloid beta antibody.
Analytical Sciences, 28 (2012) 73-76.
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Masafumi Sakono, Tamotsu
Zako, Masafumi Yohda and Mizuo Maeda:
Amyloid oligomer detection by
immobilized molecular chaperone.
Biochemical Engineering Journal, 61 (2012) 28-33.
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Tomohiro Hiraishi, Koichi
Yamashita, Masafumi Sakono, Jun Nakanishi, Tan Liu Tzea, Kumar Sudesh,
Hideki Abe, and Mizuo Maeda:
Cell Surface Display of
Functionally Active PHB Depolymerase on Escherichia coli.
Macromolecular Bioscience, 12 (2012) 218-224. (Selected as Cover picture)
- Tamotsu Zako, Masafumi Sakono, Takahiro Kobayashi, Karin Sörgjerd, K.
Peter R. Nilsson, Per Hammarström, Mikael Lindgren, and Mizuo Maeda:
Cell interaction study of amyloid using luminescent conjugated
polythiophene: Implication that amyloid cytotoxicity is correlated with
prolonged cellular binding.
ChemBioChem, 13 (2012) 358-363.
- Masayuki
Izumi, Yutaka Makimura, Simone Dedola, Akira Seko, Akiko Kanamori, Masafumi
Sakono, Yukishige Ito, and Yasuhiro Kajihara:
Chemical Synthesis of Intentionally Misfolded Homogeneous Glycoprotein: A
Unique Approach for the Study of Glycoprotein Quality Control.
Journal of the American Chemical Society, 134 (2012) 7238-7241.
- Masafumi Sakono, Akira Seko, Yoichi Takeda, Masakazu Hachisu, and Yukishige Ito:
Biophysical properties of UDP-glucose:glycoprotein glucosyltransferase, a
folding sensor enzyme in the ER, delineated by synthetic probes.
Biochemical and Biophysical Research Communications, 426 (2012) 504-510.
- Masafumi Sakono, Arata Utsumi, Tamotsu Zako, Tetsuya Abe, Masafumi Yohda and Mizuo
Maeda:
Formation of non-toxic Aβ fibrils by small heat shock protein under heat-stress
conditions.
Biochemical and Biophysical Research Communications, 430 (2013) 1259-1264.
- Karin
Margareta Sörgjerd, Tamotsu Zako, Masafumi Sakono, Peter C. Stirling,
Michel R. Leroux, Takashi Saito, Per Nilsson, Misaki Sekimoto, Takaomi C.
Saido, and Mizuo Maeda:
Human Prefoldin Inhibits Amyloid-β (Aβ) Fibrillation and Contributes to
Formation of Nontoxic Aβ Aggregates.
Biochemistry, 52 (2013) 3532-3542.
- Yoichi
Takeda, Akira Seko, Masafumi Sakono, Masakazu Hachisu, Akihiko Koizumi,
Kohki Fujikawa, Yukishige Ito:
Parallel quantification of lectin–glycan interaction using ultrafiltration.
Carbohydrate Research, 375 (2013) 112-117.
- Simone Dedola, Masayuki Izumi, Yutaka Makimura, Akira Seko, Akiko Kanamori,
Masafumi Sakono, Yukishige Ito, Yasuhiro Kajihara:
Folding of Synthetic Homogeneous Glycoproteins in the Presence of a Glycoprotein Folding Sensor Enzyme
Angewandte Chemie International Edition, 53 (2014) 2883-2887.
- Masafumi Sakono, Akira Seko, Yoichi Takeda, Jun-ichi Aikawa, Masakazu Hachisu, Akihiko
Koizumi, Kohki Fujikawa, Yukishige Ito:
Glycan specificity of a testis-specific lectin chaperone calmegin and effects of hydrophobic interactions
Biochimica et Biophysica Acta (BBA) - General Subjects, 1840 (2014) 2904-2913.
- Masafumi Sakono, Akira Seko, Yoichi Takeda, Yukishige Ito:
PDI family protein ERp29 forms 1:1 complex with lectin chaperone calreticulin
Biochemical and Biophysical Research Communications, (2014) in press
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- 趣 味
- 料理と読書と映画

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