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Japan Science and Technology Agency.

Creation of a novel technology towards diagnosis and treatment based un understanding of molecular pathogenesis of psychiatric and neurological disorders
Research Themes, Principle Investigators

Sobue Team

Researcher's name Gen Sobue
Professor,Nagoya University
Research Themes Development of molecular targeted therapy for sporadic ALS based on creation of animal models


Amyotrophic lateral sclerosis (ALS) is sporadic in over 90% cases. Its pathogenesis remains largely elusive and the basic remedy for this disease is not established so far. In this CREST project we will develop animal models mimicking molecular events observed in the pathological tissues of sporadic ALS patients and clarify molecular pathogenesis and target molecules leading to motor neuron degeneration. Moreover we will develop molecular targeted therapy and aim for its clinical application.