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Japan Science and Technology Agency.

Creation of a novel technology towards diagnosis and treatment based un understanding of molecular pathogenesis of psychiatric and neurological disorders
Research Themes, Principle Investigators

Takahashi Team

Researcher's name Ryosuke Takahashi
Professor, Kyoto University
Research Themes Elucidation of Parkinson's disease (PD) gene networks and establishment of strategies for treating PD


Parkinson's disease (PD), which is characterized by progressive and selective degeneration of dopaminergic neurons, is the second most common neurodegenerative disorder affecting more than 100,000 patients in Japan. Development of rational and radical remedies for PD based on correct understanding of its pathogenesis is an urgent issue in aging societies. In this project, we establish genetic models of PD in tissue culture cells, Medaka fish and mice, each harboring a single or multiple mutations in genes responsible for or associated with familial PD. With these complementary model systems, we clarify the complex pathophysiology of PD that involves the endoplasmic reticulum stress response, protein degradation mechinery, mitochondria and dopamine metabolism. The goals of our project are to generate research resources, to define molecular targets, and to discover small-molecule lead compounds, for the treatment of PD and related neurodegenerative disorders.