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  • FY 2010
  • FY 2011
  • FY 2012

  • Motoyuki OTSUKA
  • Hiroki KATO
  • Takayuki KURAISHI
  • Takashi SAITO
  • Mitoaki SANO
  • Takayoshi SUGANAMI
  • Takahisa NAKAMURA
  • Rikinari HANAYAMA

Takayoshi Suganami – Molecular mechanisms underlying obesity-induced chronic inflammation


Takayoshi Suganami
Professor, Department of Molecular Medicine and Metabolism, Research Institute of Environmental Medicine, Nagoya University
Research Theme
Molecular mechanisms underlying obesity-induced chronic inflammation

Obesity may be viewed as a chronic low-grade inflammatory disease as well as a metabolic disease. Storing excessive energy as triglyceride is a fundamental function of adipose tissue. During the course of obesity, reduced capacity of lipid storage in adipose tissue contributes to ectopic lipid accumulation in non-adipose tissues such as liver and skeletal muscle, where lipotoxicity impairs their metabolic functions. In this regard, saturated fatty acids derived from obese adipose tissue may play a key role in the pathophysiology of obesity-induced metabolic derangement. The aim of this study is to explore the molecular mechanisms underlying obesity-induced chronic inflammation.

Research Results
The 5 Cardinal Signs of Inflammation