Researchers
Yasushi Hirota – Molecular aspects of senescence-induced inflammation in mouse models of female reproductive diseasesl
Researcher
- Yasushi Hirota
- Assistant Professor, Obstetrics and Gynecology, The University of Tokyo
Research Theme
Molecular aspects of senescence-induced inflammation in mouse models of female reproductive diseasesl
High incidence of preterm birth caused by maternal ageing is currently one of the major clinical problems in reproductive medicine. The relationship between chronic uterine inflammation and preterm labor has been suggested, but its pathopysiology remains to be elucidated. I propose here a project to examine the mechanism of senescence-induced inflammation by using uterine specific p53 deleted mice as a novel model of uterine ageing-induced preterm delivery. My major focus will be clarifying novel molecular pathways employed by p53 and p21, key regulators of cellular ageing and senescence. The ultimate goal of the project is to discover a new therapeutic approach to preterm delivery by preventing uterine inflammation and/or senescence.
