Reserach

Researchers

CRESTPRESTO
  • FY 2010
  • FY 2011
  • FY 2012

  • Team KOMURO
  • Team NAKAYAMA
  • Team NUREKI
  • Team MATSUMOTO
  • Team YASUTOMO
  • Team YAMAMOTO

Masayuki Yamamoto - Protective mechanisms against environmental stresses leading to therapeutic strategies for chronic inflammation

Principle Investigator

Masayuki Yamamoto
Tohoku University
Professor
http://www.dmbc.med.tohoku.ac.jp/official/index_E.html
Research Theme
Protective mechanisms against environmental stresses leading to therapeutic strategies for chronic inflammation

We are constantly exposed to various environmental stresses in our daily life, including chemicals, ultra-violet light, pathogenic microorganisms, and dietary toxicants. Cellular detoxification is crucial for the maintenance of health by providing protection against these environmental stresses. The aim of this study is to clarify how dysregulation of stress responses exacerbates chronic inflammatory diseases and also, to evaluate the effectiveness of intervention into the cytoprotection mechanisms to prevent and alleviate these pathologic conditions. Our research aims to identify novel relationships between environmental stresses and chronic inflammation and provide advances in therapeutic strategies for chronic inflammatory diseases.

diagram

Research Results
The 5 Cardinal Signs of Inflammation