Research Theme

Next-generation imaging technology dissecting in vivo mode of action of chronic inflammatory macrophages

Chronic inflammation causes many diseases, including arthritis and autoimmune diseases, however, precise molecular mechanisms how termination of inflammatory response is disturbed remains unclear. Here we will address this question by examining the role of microRNA in inflammation and arthritis pathogenesis. Utilizing high throughput sequencer and cell-based functional screening systems, we will uncover novel molecular cascade regulating inflammatory time signal at RNA level. This may provide a novel targets or strategy for inflammatory diseases, such as rheumatoid arthritis.

Research Results