プロジェクト期間中の論文一覧 | 山中伸弥の受賞一覧 | プロジェクト関係者受賞一覧

プロジェクト期間中の論文一覧

2013年

5.) Nasu A, Ikeya M, Yamamoto T, Watanabe A, Jin Y, Matsumoto Y, Hayakawa K, Amano N, Sato S, Osafune K, Aoyama T, Nakamura T, Kato T, Toguchida J.
Genetically matched human iPS cells reveal that propensity for cartilage and bone differentiation differs with clones, not cell type of origin.
PLoS One (in press)

4.) Mae SI, Shono A, Shiota F,Yasuno T, Kajiwara M, Gotoda-Nishimura N, Arai S, Sato-Otubo A, Toyoda T, Takahashi K, Nakayama N, Cowan CA, Aoi T, Ogawa S, McMahon AP, Yamanaka S, Osafune K. Monitoring and robust induction of nephrogenic intermediate mesoderm from human pluripotent stem cells.
Nature Communications (in press)

3.) Kawai G, Ohono T, Kawaguchi T, Nagano A, Sitou M, Takigami I, Matsuhashi A, Yamada K, Hosono K, Tezuka K, Kunisada T, Hara A, Shimizu K.
Human dental pulp facilitates bone regeneration in a rat bone defect model.
Bone and Tissue Regeneration Insights (in press)

2.) Yamada K, Ohno T, Aoki H, Semi K, Watanabe A, Moritake H, Shiozawa S, Kunisada T, Kobayashi Y, Toguchida J, Shimizu K, Hara A and Yamada Y.
EWS/ATF1 expression induces sarcomas from neural crest-derived cells in mice.
J. Clin Invest.(in press)

1.) Hirata A, Utikal J, Yamashita S, Aoki H, Watanabe A, Yamamoto T, Okano H, Bardeesy N, Kunisada T, Ushijima T, Hara A, Jaenisch R, Hochedlinger K, Yamada Y.
Dose-dependent roles for canonical Wnt signalling in de novo crypt formation and cell cycle properties of the colonic epithelium.
Development 140(1):66-75. 2013

2012年

27.) Yamana R, Iwasaki M, Wakabayashi M, Nakagawa M, Yamanaka S, Ishihama Y.
Rapid and Deep Profiling of Human Induced Pluripotent Stem Cell Proteome by One-shot NanoLC-MS/MS Analysis with Meter-scale Monolithic Silica Columns.
J Proteome Res. [ePub ahead of print 2012 Dec 4.]

26.) Semi K, Matsuda Y, Ohnishi K, Yamada Y.
Cellular reprogramming and cancer development.
Int J Cancer 2012 Nov 26. doi: 10.1002/ijc.27963. [ePub ahead of print]

25.) Okita K, Yamakawa T, Matsumura Y, Sato Y, Amano N, Watanabe A, Goshima N, Yamanaka S.
An Efficient Non-viral Method to Generate Integration-Free Human iPS Cells from Cord Blood and Peripheral Blood Cells.
Stem Cells 2012 Nov 29. doi: 10.1002/stem.1293. [ePub ahead of print]

24.) Minami I, Yamada K, Otsuji TG, Yamamoto T, Shen Y, Otsuka S, Kadota S, Morone N, Barve M, Asai Y, Tenkova-Heuser T, Heuser EJ, Uesugi M, Aiba A, Nakatsuji
NA. A novel small molecule that promotes cardiac differentiation of human pluripotent stem cells under defined, cytokine- and xeno-free conditions.
Cell Reports 2: 1-13, 2012

23.) Maehara M, Matsunari H, Honda K, Nakano K, Takeuchi Y, Kanai T, Matsuda T, Matsumura Y, Hagiwara Y, Sasayama N, Shirasu A, Takahashi M, Watanabe M, Umeyama K, Hanazono Y, Nagashima H.
Hollow Fiber Vitrification Provides a Novel Method for Cryopreserving In Vitro Maturation/Fertilization-Derived Porcine Embryos.
Biol Reprod. 87(6):133, 1-8 (ePub ahead of print 2012 Oct 10)

22.) Fujishiro SH, Nakano K, Mizukami Y, Azami T, Arai Y, Matsunari H, Ishino R, Nishimura T, Watanabe M, Abe T, Furukawa Y, Umeyama K, Yamanaka S, Ema M, Nagashima H, Hanazono Y.
Generation of Naive-Like Porcine-Induced Pluripotent Stem Cells Capable of Contributing to Embryonic and Fetal Development.
Stem Cells Dev  [ePub ahead of print 2012 Oct 9.]

21.) Naganuma T, Nakagawa S, Tanigawa A, Sasaki YF, Goshima N, Hirose T.
Alternative 3'-end processing of long noncoding RNA initiates construction of nuclear paraspeckles.
31(20):4020-34. 2012 (Epub 2012 Sep 7)

20.) Arioka Y, Watanabe A, Saito K, Yamada Y.
Activation-induced cytidine deaminase alters the subcellular localization of Tet family proteins.
PLoS One 7(9):e45031, 2012

19.) Egawa N, Kitaoka S, Tsukita K, Naitoh M, Takahashi K, Yamamoto T, Adachi F, Kondo T, Okita K, Asaka I, Aoi T, Watanabe A, Yamada Y, Morizane A, Takahashi J, Ayaki T, Ito H, Yoshikawa K, Yamawaki S, Suzuki S, Watanabe D, Hioki H, Kaneko T, Makioka K, Okamoto K, Takuma H, Tamaoka A, Hasegawa K, Nonaka T, Hasegawa M, Kawata A, Yoshida M, Nakahata T, Takahashi R, Marchetto MC, Gage FH, Yamanaka S, Inoue H.
Drug screening for ALS using patient-specific induced pluripotent stem cells.
Sci Transl Med. 4(145):145ra104, 2012

18.) Kajiwara M, Aoi T, Okita K, Takahashi R, Inoue H, Takayama N, Endo H, Eto K, Toguchida J, Uemoto S, Yamanaka S.
Donor-dependent variations in hepatic differentiation from human-induced pluripotent stem cells.
PNAS 109(31):12538-43. 2012 (ePub 2012 Jul 16)

17.) Tanaka T, Takahashi K, Yamane M, Tomida S, Nakamura S, Oshima K, Niwa A, Nishikomori R, Kambe N, Hara H, Mitsuyama M, Morone N, Heuser JE, Yamamoto T, Watanabe A, Sato-Otsubo A, Ogawa S, Asaka I, Heike T, Yamanaka S, Nakahata T, Saito MK.
Induced pluripotent stem cells from CINCA syndrome patients as a model for dissecting somatic mosaicism and drug discovery.
Blood 2012 120(6):1299-308. 2012 (ePub 2012 Jun 21)

16.) Tomoda K, Takahashi K, Leung K, Okada A, Narita M, Yamada NA, Eilertson KE, Tsang P, Baba S, White MP, Sami S, Srivastava D, Conklin BR, Panning B, Yamanaka S.
Derivation conditions impact X-inactivation status in female human induced pluripotent stem cells.
Cell Stem Cell. 11(1):91-9. 2012

15.) Okabayashi K, Fujita T, Miyazaki J, Okada T, Iwata T, Hirao N, Noji S, Tsukamoto N, Goshima N, Hasegawa H, Takeuchi H, Ueda M, Kitagawa Y, Kawakami Y.
Cancer-testis antigen BORIS is a novel prognostic marker for patients with esophageal cancer.
Cancer Sci. 103(9):1617-24. 2012 (ePub 2012 Jul 16

14.) Miki K, Uenaka H, Saito A, Miyagawa S, Sakaguchi T, Higuchi T, Shimizu T, Okano T, Yamanaka S, Sawa Y.
Bioengineered myocardium derived from induced pluripotent stem cells improves cardiac function and attenuates cardiac remodeling following chronic myocardial infarction in rats.
Stem Cells Transl Med. 1(5):430-7. 2012 (ePub 2012 May 14)

13.) Chujo T, Ohira T, Sakaguchi Y, Goshima N, Nomura N, Nagao A, Suzuki T.
LRPPRC/SLIRP suppresses PNPase-mediated mRNA decay and promotes polyadenylation in human mitochondria.
Nucleic Acids Res. 40(16):8033-47. 2012 (ePub 2012 May 31)

12.) Arikata M, Itoh Y, Okamatsu M, Maeda T, Shiina T, Tanaka K, Suzuki S, Nakayama M, Sakoda Y, Ishigaki H, Takada A, Ishida H, Soda K, Pham VL, Tsuchiya H, Nakamura S, Torii R, Shimizu T, Inoko H, Ohkubo I, Kida H, Ogasawara K.
Memory immune responses against pandemic (H1N1) 2009 influenza virus induced by a whole particle vaccine in cynomolgus monkeys carrying Mafa-A1*052:02.
PLoS One 7(5):e37220. 2012

11.) Matsumoto T, Ryuge S, Kobayashi M, Kageyama T, Hattori M, Goshima N, Jiang SX, Saegusa M, Iyoda A, Satoh Y, Masuda N, Sato Y.
Anti-HuC and -HuD autoantibodies are differential sero-diagnostic markers for small cell carcinoma from large cell neuroendocrine carcinoma of the lung.
Int J Oncol. 40(6):1957-62. 2012 (ePub 2012 Mar 16)

10.) Saito M, Kato Y, Ito E, Fujimoto J, Ishikawa K, Doi A, Kumazawa K, Matsui A, Takebe S, Ishida T, Azuma S, Mochizuki H, Kawamura Y, Yanagisawa Y, Honma R, Imai J, Ohbayashi H, Goshima N, Semba K, Watanabe S.
Expression screening of 17q12-21 amplicon reveals GRB7 as an ERBB2-dependent oncogene.
FEBS Lett. 586(12):1708-14. 2012 (ePub 2012 May 11)

9.) Wada T, Goparaju SK, Tooi N, Inoue H, Takahashi R, Nakatsuji N, Aiba K..
Amyotrophic Lateral Sclerosis Model Derived from Human Embryonic Stem Cells Overexpressing Mutant Superoxide Dismutase 1.
Stem Cells Transl Med 1(5):396-402. 2012

8.) Kobayashi M, Matsumoto T, Ryuge S, Yanagita K, Nagashio R, Kawakami Y, Goshima N, Jiang SX, Saegusa M, Iyoda A, Satoh Y, Masuda N, Sato Y.
CAXII Is a sero-diagnostic marker for lung cancer.
PLoS One 7(3):e33952. 2012

7.) Aoki H, Hara A, Era T, Kunisada T, Yamada Y.
Genetic ablation of Rest leads to in vitro-specific derepression of neuronal genes during neurogenesis.
Development 139: 667-677, 2012

6.) Abe T, Masuda S, Tanaka Y, Nitta S, Kitano Y, Hayashi S, Hanazono Y, Nagao Y. Maternal administration of busulfan before in utero transplantation of human hematopoietic stem cells enhances engraftments in sheep.
Exp Hematol. 40(6):436-44, 2012

5.) Yamamoto H, Ida T, Tsutsuki H, Mori M, Matsumoto T, Kohda T, Mukamoto M, Goshima N, Kozaki S, Ihara H.
Specificity of botulinum protease for human VAMP family proteins: Specificity of botulinum protease.
Microbiol Immunol. 56(4):245-53 2012 (ePub ahead of print 2012 Jan 30)

4.) Morichika J, Iwatani C, Tsuchiya H, Nakamura S, Sankai T, Torii R.
Triple pregnancy in a cynomolgul monkey (Macaca faciscicularis) after double embryo transfer.
Comp Med 62(1):69-72, 2012

3.) Matsumura S, Hamasaki M, Yamamoto T, Ebisuya M, Sato M, Nishida E, Toyoshima F.
ABL1 regulates spindle orientation in adherent cells and mammalian skin.
Nature Communications 3:626, 2012

2.) Okahara-Narita J, Umeda R, Nakamura S, Mori T, Noce T, Torii R.
Induction of pluripotent stem cells from fetal and adult cynomolgus monkey fibroblasts using four human transcription factors.
Primate 53(2):205-13, 2012

1.) Masuda S, Yokoo T, Sugimoto N, Doi M, Fujishiro S, Takeuchi K, Kobayashi E, Hanazono Y.
A simplified in vitro teratoma assay for pluripotent stem cells injected into rodent fetal organs.
Cell Med. 3(1):103-112. 2012

2011年

30.) H, Baker J, Baker D, Munoz MB, Beil S, Benvenisty N, Ben-Yosef D, Biancotti JC, Bosman A, Brena RM, Brison D, Caisander G, Camarasa MV, Chen J, Chiao E, Choi YM, Choo AB, Collins D, Colman A, Crook JM, Daley GQ, Dalton A, De Sousa PA, Denning C, Downie J, Dvorak P, Montgomery KD, Feki A, Ford A, Fox V, Fraga AM, Frumkin T, Ge L, Gokhale PJ, Golan-Lev T, Gourabi H, Gropp M, Lu G, Hampl A, Harron K, Healy L, Herath W, Holm F, Hovatta O, Hyllner J, Inamdar MS, Irwanto AK, Ishii T, Jaconi M, Jin Y, Kimber S, Kiselev S, Knowles BB, Kopper O, Kukharenko V, Kuliev A, Lagarkova MA, Laird PW, Lako M, Laslett AL, Lavon N, Lee DR, Lee JE, Li C, Lim LS, Ludwig TE, Ma Y, Maltby E, Mateizel I, Mayshar Y, Mileikovsky M, Minger SL, Miyazaki T, Moon SY, Moore H, Mummery C, Nagy A, Nakatsuji N, Narwani K, Oh SK, Oh SK, Olson C, Otonkoski T, Pan F, Park IH, Pells S, Pera MF, Pereira LV, Qi O, Raj GS, Reubinoff B, Robins A, Robson P, Rossant J, Salekdeh GH, Schulz TC, Sermon K, Sheik Mohamed J, Shen H, Sherrer E, Sidhu K, Sivarajah S, Skottman H, Spits C, Stacey GN, Strehl R, Strelchenko N, Suemori H, Sun B, Suuronen R, Takahashi K, Tuuri T, Venu P, Verlinsky Y,
International Stem Cell Initiative, Amps K, Andrews PW, Anyfantis G, Armstrong L, Avery S, BaharvandWard-van Oostwaard D, Weisenberger DJ, Wu Y, Yamanaka S, Young L, Zhou Q.
Screening ethnically diverse human embryonic stem cells identifies a chromosome 20 minimal amplicon conferring growth advantage.
Nat Biotechnol. 2011 29(12):1132-44.

29.) Yagi T, Okada Y, Akamatsu W, Yoshizaki T, Yamanaka S, Okano H, Suzuki N.
Modeling familial Alzheimer's disease with induced pluripotent stem cells.
Hum Mol Genet 20(23)4530-9 (ePub 2011 Sep 7)

28.) Nakamura T, Nakagawa M, Ichisaka T, Shiota A, Yamanaka S.
Essential roles of ECAT15-2/Dppa2 in functional lung development.
Mol Cell Biol 31(21)4366-78 (ePub 2011 Sep 6)

27.) Wang YC, Nakagawa M, Garitaonandia I, Slavin I, Altun G, Lacharite RM, Nazor KL, Tran HT, Lynch CL, Leonardo TR,Liu Y, Peterson SE, Laurent LC, Yamanaka S, Loring JF.
Specific lectin biomarkers for isolation of human pluripotent stem cells identified through array-based glycomic analysis.
Cell Res 21(11)1551-63 (ePub 2011 Sep 6)

26.) Uosaki H, Fukushima H, Takeuchi A, Matsuoka S, Nakatsuji N, Yamanaka S, Yamashita JK.
Efficient and Scalable Purification of Cardiomyocytes from Human Embryonic and Induced Pluripotent Stem Cells by VCAM1 Surface Expression Plos One
6(8):e23657 (ePub 2011 Aug 8)

25.) Nori S, Okada Y, Yasuda A, Tsuji O, Takahashi Y, Kobayashi Y, Fujiyoshi K, Koike M, Uchiyama Y, Ikeda E, Toyama Y, Yamanaka S, Nakamura M, Okano H.
Grafted human-induced pluripotent stem-cell-derived neurospheres promote motor functional recovery after spinal cord injury in mice.
PNAS 108(40):16825-30. 2011(ePub 2011 Sep 26)

24.) Masuda S, Hayashi S, Ageyama N, Shibata H, Abe T, Nagao Y, Hanazono Y.
Migration of cells from the yolk-sac to hematopoietic tissues after in utero transplantation of early and mid gestation canine fetuses.
Transplantation 92(2):e5-6. 2011

23.) Masuda S, Hanazono Y.
Patient-specific induced pluripotent stem-cell models for long-QT syndrome.
N Engl J Med. 364(2):181-2. 2011

22.) Abe T, Masuda S, Ban H, Hayashi S, Ueda Y, Inoue M, Hasegawa M, Nagao Y, Hanazono Y.
Ex vivo expansion of human HSCs with Sendai virus vector expressing HoxB4 assessed by sheep in utero transplantation.
Exp Hematol. 39(1):47-54. 2011 (ePub 2011 Sep 26.)

21.) Nakamura S, Tsuchiya H, Okahara N, Nakagawa T, Ohara N, Yamamoto H, Li T, Takeda N, Ogasawara K, Torii R.
Epidemiology of hepatitis E virus in indoor-captive cynomolgus monkey colony.
J Vet Med Sci 74(3):279-83 (ePub 2011 Oct 12)

20.) Kitano M, Itoh Y, Kodama M, Ishigaki H, Nakayama M, Ishida H, Baba K, Noda T, Sato K, Nihashi Y, Kanazu T, Yoshida R, Torii R, Sato A, Ogasawara K.
Efficacy of single intravenous injection of peramivir against influenza B virus infection in ferrets and cynomologus macaques.
Antimicrob Agents Chemother 55(11):4961-70. 2011

19.) Yamasaki J、Iwatani C, Tsuchiya H, Okahara J, Sankai T, Torii R .
Vitrification and transfer of cynomolgus monkey (Macaca fascicularis) embryos fertilized by intracytoplasmic sperm injection.
Theriogenology 76, 33-38. 2011

18.) Maruyama Y, Kawamura Y, Nishikawa T, Isogai T, Nomura N, Goshima N.
HGPD: Human Gene and Protein Database.
Nucleic Acids Research 40(D1)D924-929 2011

17.) Yamaguchi K, Inoue M, Goshima N.
Efficient protein transduction method using cationic peptides and lipids.
J Biomed Biotech 2011:872065(ePub 2011 Oct 12)

16.) Matsumoto T, Ryuge S, Kobayashi M, Kageyama T, Hattori M, Goshima N,
Jiang SX, Saegusa M, Iyoda A, Satoh Y, Masuda N, Sato Y.
Anti-HuC and HuD autoantibodies are differential sero-diagnostic markers for small cell carcinoma from large cell neuroendocrine carcinoma of the lung.
Int J Oncol 39(5)1109-15, 2011

15.) Hirose S, Kawamura Y, Mori M, Yokota K, Noguchi T, Goshima N.
Development and evaluation of data-driven designed tags (DDTs) for controlling protein solubility.
New Biotechnology 28(3), 225-231. 2011

14.) Miyamoto K, Iwadate M, Yanagisawa Y, Ito E, Imai J, Yamamoto M, Sawada N, Saito M, Suzuki S, Nakamura I, Ohki S, Saze Z, Kogure M, Gotoh M, Omicronbara K, Ohira H, Tasaki K, Abe M, Goshima N, Watanabe S, Waguri S, Takenoshita S.
Cathepsin L is highly expressed in gastrointestinal stromal tumors.
Int J Oncol 39(5):1109-15. 2011

13.) Matsuyama M, Goto H, Kasahara K, Kawakami Y, Nakanishi M, Kiyono T, Goshima N, Inagaki M. Nuclear Chk1 prevents premature mitotic entry.
J Cell Sci 124:2113-9. 2011

12.) Hirose S, Kawamura Y, Yokota K, Kuroita T, Natsume T, Komiya K, Tsutsumi T, Suwa Y, Isogai T, Goshima N, Noguchi T.
Statistical analysis of features associated with protein expression/solubility in an in vivo Escherichia coli expression system and a wheat germ cell-free expression system.
J Biochem 150 (1):73-81. 2011

11.) Pandian GN, Shinohara KI, Ohtsuki A, Nakano Y, Masafumi M, Bando T, Nagase H, Yamada Y, Watanabe A, Terada N, Sato S, Morinaga H, Sugiyama H.
Synthetic Small Molecules for Epigenetic Activation of Pluripotency Genes in Mouse Embryonic Fibroblasts.
Chembiochem 2011 Oct 28. doi: 10.1002/cbic.201100597

10.) Watanabe A, Ogiwara H, Ehata S, Mukasa A, Ishikawa S, Maeda D, Ueki K, Ino Y, Todo T, Yamada Y, Fukayama M, Saito N, Miyazono K, Aburatani H..
Homozygously deleted gene DACH1 regulates tumor-initiating activity of glioma cells.
PNAS 108(30):12384-9. 2011

9.) Yahata N, Asai M, Kitaoka S, Takahashi K, Asaka I, Hioki H, Kaneko T, Maruyama K, Saido TC, Nakahata T, Asada T, Yamanaka S, Iwata N, Inoue H.
Anti-Aβ drug screening platform using human iPS cell-derived neurons for the treatment of Alzheimer's disease.
PLoS One 6(9):e25788. 2011

8.) Lahti AL, Kujala VJ, Chapman H, Koivisto AP, Pekkanen-Mattila M, Kerkelä E, Hyttinen J, Kontula K, Swan H, Conklin BR, Yamanaka S, Silvennoinen O, Aalto-Setälä K.
Human disease model for long QT syndrome type 2 using iPS cells demonstrates arrhythmogenic characteristics in cell culture.
Dis Model Mech  [ePub ahead of print 2011 Nov 3.]

7.) Hiratsuka M, Uno N, Ueda K, Kurosaki H, Imaoka N, Kazuki K, Ueno E, Akakura Y, Katoh M, Osaki M, Kazuki Y, Nakagawa M, Yamanaka S, Oshimura M.
Integration-Free iPS Cells Engineered Using Human Artificial Chromosome Vectors.
PLoS One 6(10):e25961. 2011

6.) Denda K, Nakao-Wakabayashi K, Okamoto N, Ryu JY, Tagawa Y, Ichisaka T, Yamanaka S, Komada M. Nrk, an X-linked protein kinase in the germinal center kinase family, is required for placental development and fetoplacental induction of labor.
J Biol Chem 286 (33):28802-10. 2011 (ePub 2011 Jun 29)

5.) Maekawa M, Yamaguchi K, Nakamura T, Shibukawa R, Kodanaka I, Ichisaka T, Kawamura Y, Mochizuki H, Goshima N, Yamanaka S.
Direct reprogramming of somatic cells is promoted by maternal transcription factor Glis1. Nature 474(7350):225-9. 2011

4.) Iwabuchi KA, Yamakawa T, Sato Y, Ichisaka T, Takahashi K, Okita K, Yamanaka S.
ECAT11/Ltd1 is enriched in ES cells and rapidly activated during iPS cell generation, but it is dispensable for the maintenance and induction of pluriopotency.
PLoS One. 6(5):e20461. 2011

3.) Okita K, Matsumura Y, Sato Y, Okada A, Morizane A, Okamoto S, Hong H, Nakagawa M, Tanabe K, Tezuka K, Shibata T, Kunisada T, Takahashi M, Takahashi J, Saji H, Yamanaka S.
A more efficient method to generate integration-free human iPS cells Nature Method 
8(5):409-12. 2011 (ePub 2011 Apr 3)

2.) Fujiwara M, Yan P, Otsuji TG, Narazaki G, Uosaki H, Fukushima H, Kuwahara K, Harada M, Matsuda H, Matsuoka S, Okita K, Takahashi K, Nakagawa M, Ikeda T, Sakata R, Mummery CL, Nakatsuji N, Yamanaka S, Nakao K, Yamashita JK.
Induction and enhancement of cardiac cell differentiation from mouse and human induced pluripotent stem cells with cyclosporin-a.
PLoS One 6(2):e16734. 2011,

1.) Ohta S, Imaizumi Y, Okada Y, Akamatsu W, Kuwahara R, Ohyama M, Amagai M, Matsuzaki Y, Yamanaka S, Okano H, Kawakami Y.
Generation of human melanocytes from induced pluripotent stem cells.
PLoS One 6(2):e16182. 2011

2010年

22.) Tanaka Y, Masuda S, Abe T, Hayashi S, Kitano Y, Nagao Y, Hanazono Y.
Intravascular route is not superior to an intraperitoneal route for in utero transplantation of human hematopoietic stem cells and engraftment in sheep.
Transplantation 90(4):462-3. 2010

21.) Kitano M, Itoh Y, Kodama M, Ishigaki H, Nakayama M, Nagata T, Ishida H, Tsuchiya H, Torii R, Baba K, Yoshida R, Sato A, Ogasawara K.
Establishment of a cynomolgus macaque model of influenza B virus infection.
Virology 407(2):178-84. 2010 (ePub 2010 Sep 6.)

20.) Miyake T, Soda K, Itoh Y, Sakoda Y, Ishigaki H, Nagata T, Ishida H, Nakayama M, Ozaki H, Tsuchiya H, Torii R, Kida H, Ogasawara K.
Amelioration of pneumonia with Streptococcus pneumoniae infection by inoculation with a vaccine against highly pathogenic avian influenza virus in a non-human primate mixed infection model.
J Med Primatol 39(1):58-70. 2010

19.) Itoh Y, Ozaki H, Ishigaki H, Sakoda Y, Nagata T, Soda K, Isoda N, Miyake T, Ishida H, Okamoto K, Nakayama M, Tsuchiya H, Torii R, Kida H, Ogasawara K.
Subcutaneous inoculation of a whole virus particle vaccine prepared from a non-pathogenic virus library induces protective immunity against H7N7 highly pathogenic avian influenza virus in cynomolgus macaques.
Vaccine 28(3):780-9. 2010

18.) Kuramochi-Miyagawa S, Watanabe T, Gotoh K, Takamatsu K, Chuma S, Kojima-Kita K, Shiromoto Y, Asada N, Toyoda A, Fujiyama A, Totoki Y, Shibata T, Kimura T, Nakatsuji N, Noce T, Sasaki H, Nakano T.
MVH in piRNA Processing and Gene Silencing of Retrotransposons.
Gene Develop 24:887-892. 2010

17.) Aoki H, Hara A, Motohashi T, Osawa M, Kunisada T.
Functionally distinct melanocyte populations revealed by reconstitution of hair follicles in mice.
Pigment Cell Melanoma Res. 24(1):125-35.2010 (ePub 2010 Nov 19)

16.) Iida K, Takeda-Kawaguchi T, Tezuka Y, Kunisada T, Shibata T, Tezuka K.
Hypoxia enhances colony formation and proliferation but inhibits differentiation of human dental pulp cells.
Arch Oral Biol. 55(9):648-54. 2010 (ePub 2010 Jul 13)

15.) Hara A, Taguchi A, Aoki H, Hatano Y, Niwa M, Yamada Y, Kunisada T.
Folate antagonist, methotrexate induces neuronal differentiation of human embryonic stem cells transplanted into nude mouse retina. Neurosci Lett.
2010 Jun 25:477(3):138-43. 2010 (Epub 2010 Apr 29)

14.) Yamada Y, Aoki H, Kunisada T, Hara A.
Rest promotes the early differentiation of mouse ESCs but is not required for their maintenance.
Cell Stem Cell. 6(1):10-15, 2010

13.) Takayama N, Nishimura S, Nakamura S, Shimizu T, Ohnishi R, Endo H, Yamaguchi T, Otsu M, Nishimura K, Nakanishi M, Sawaguchi A, Nagai R, Takahashi K, Yamanaka S, Nakauchi H, Eto K.
Transient activation of c-Myc expression is critical for efficient platelet generation from human induced pluripotent stem cells.
J Exp Med 207(13):2817-30. 2010 (ePub 2010 Nov 22)

12.) Egusa H, Okita K, Kayashima H, Yu G, Fukuyasu S, Saeki M, Matsumoto T, Yamanaka S, Yatani H.
Gingival fibroblasts as a promising source of induced pluripotent stem cells.
Plos One 5(9):e12743. 2010

11.) Espejel S, Roll GR, McLaughlin KJ, Lee AY, Zhang JY, Laird DJ, Okita K, Yamanaka S,
Willenbring H. Induced pluripotent stem cell-derived hepatocytes have the functional and proliferative capabilities needed for liver regeneration in mice.
J Clin Invest 120(9):3102-5. 2010 (ePub Aug 25)

10.) Imamura M, Aoi T, Tokumasu A, Mise N, Abe K, Yamanaka S, Noce T.
Induction of primordial germ cells from mouse induced pluripotent stem cells derived from adult hepatocytes.
Mol Reprod Dev 77(9):802-11. 2010

9.) Saunders LR, Sharma AD, Tawney J, Nakagawa M, Okita K, Yamanaka S,
Willenbring H, Verdin E. miRNA regulate SIRT1 expression during mouse embryonic stem cell diffferentiation and in adult mouse tissues.
Aging 2(7):415-31. 2010

8.) Nakagawa M, Takizawa N, Narita M, Ichisaka T, Yamanaka S.
Promotion of direct reprogramming by transformation-deficient Myc.
PNAS 107(32):14152-7. 2010 (ePub Jul 26)

7.) Tsuji O, Miura K, OkadaY, Fujiyoshi K, Mukaino M, Nagoshi N, Kitamura K, Kumagai G, Nishino M, Tomisato S, Higashi H, Nagai T, Katoh H, Kohda K, Matsuzaki Y, Yuaki M, Ikeda E, Toyama Y, Nakamura M, Yamanaka S, Okano H.
Therapeutic potential of appropriately evaluated safe-induced  pluripotent stem cells for spinal cord injury.
PNAS 107(28):12704-9. 2010 (ePub Jul 6)

6.) Tamaoki N, Takahashi K, Tanaka T, Ichisaka T, Aoki H, Takeda-Kawaguchi T, Iida K, Kunisada T, Shibata T, Yamanaka S, Tezuka K.
Dental pulp cells for induced pluripotent stem cell banking.
J Dent Res 89(8):773-8. 2010 (ePub 2010 Jun 16)

5.) Kaichi S, Hasegawa K, Takaya T, Yakoo N, Mima T, Kawamura T, Morimoto T, Ono K, Baba S, Doi H, Yamanaka S, Nakahata H, Heike T.
Cell line-dependent differentiation of induced pluripotent stem cells into caridomyocytes in mice.
Cardiovasc Res 88(2):314-23. 2010 (ePub Jul 15)

4.) Sato S, Yagi S, Arai Y, Hirabayashi K, Hattori N, Iwatani M, Okita K, Ohgane J, Tanaka S, Wakayama T, Yamanaka S, Shiota K.
Genome-wide DNA methylation profile of tissue-dependent and differentially methulated regions(T-DMRs) residing in mouse pluripotent stem cells.
Genes Cells 15(6):607-18. 2010 (ePub May 13)

3.) Hommma K, Sone M, Taura D, Yamahara K, Suzuki Y, Takahashi K, Sonoyama T, Inuzuka M, Fukunaga Y, Tamura N, Itoh H, Yamanaka S, Nakao K.
Sirt 1 plays an important role in mediating greater functionality of human ES/iPS-derived vascular endotherial cells.
Atherosclerosis 212((1):42-7. 2010 (ePub Apr 22)

2.) Mizuno Y, Chang H, Umeda K, Niwa A, Iwasa T, Awaya T, Fukuda SI, Yammoto H, Yamanaka S. Nakahata T, HeikeT.
Generation of skeletal muscle stem/progenitor cells from murine induced pluriotent stem cells.
FASEB J 24(7):2245-53. 2010 (ePub Feb 24)

1.) Kazuki Y, Hiratsuka M, Takiguchi M, Osaki M, Kajitani N, Hoshiya H, Hiramatsu K, Yoshino T, Kazuki K, Ishihara C, Takehara S, Higaki K, Nakagawa M, Takahashi K, Yamanaka S, Oshimura M..
Complete genetic correction of iPS cells from Duchenne muscular dystrophy.
Molecular Therapy 18:386-393. 2010 (ePub 2009 Dec 8)

2009年

27.) Haraguchi K, Suzuki T, Koyama N, Kumano K, Nakahara F, Matsumoto A, Yokoyama Y, Sakata-Yanagimoto M, Masuda S, Takahashi T, Kamijo A, Takahashi K, Takanashi M, Okuyama Y, Yasutomo K, Sakano S, Yagita H, Kurokawa M, Ogawa S, Chiba S.
Notch activation induces the generation of functional natural killer cells from human cord blood CD34-positive cells devoid of interleukin-15.
J Immunol 182(10):6168-6178. 2009

26.) Masuda S, Kumano K, Suzuki T, Tomita T, Iwatsubo T, Natsugari H, Tojo A, Shibutani M, Mitsumori K, Hanazono Y, Ogawa S, Kurokawa M, Chiba S.
Dual antitumor mechanisms of Notch signaling inhibitor in a T cell acute lymphoblastic leukemia xenograft model.
Cancer Sci 100(12): 2444-2450. 2009

25.) Masuda S, Ageyama N, Shibata H, Obara Y, Ikeda T, Takeuchi K, Ueda Y, Ozawa K, Hanazono Y.
Co-transplantation with MSCs improves the engraftment of HSCs after autologous intra-bone marrow transplantation in non-human primates.
Exp Hematol 37(10):1250-1257. 2009

24.) Nagao Y, Abe T, Hasegawa H, Tanaka Y, Sasaki K, Kitano Y, Hayashi S, Hanazono Y.
Improved efficacy and safety of in utero cell transplantation in sheep using an ultrasound-guided method.
Cloning Stem Cells 11(2):281-285. 2009

23.) Tanaka Y, Ikeda T, Kishi Y, Masuda S, Shibata H, Takeuchi K, Komura M, Iwanaka T, Muramatsu S, Kondo Y, Takahashi K, Yamanaka S, Hanazono Y.
ERas is expressed in primate embryonic stem cells but not related to tumorigenesis.
Cell Transplant 18(4):381-389. 2009

22.) Kita YF, Hosomichi K, Kohara S, Itoh Y, Ogasawara K, Tsuchiya H, Torii R, Inoko H, Blancher A, Kulski JK, Shiina T.
MHC class I A loci polymorphism and diversity in three Southeast Asian populations of cynomolgus macaque.
Immunogenetics. 61(9):635-48. 2009

21.) Aoki H, Hara A, Niwa M, Yamada Y, Kunisada T.
In vitro and in vivo differentiation of human embryonic stem cells into retina-like organs and comparison with that from mouse pluripotent epiblast stem cells.
Dev Dyn. 238(9):2266-79. 2009

20.) Aoki H, Yamada Y, Hara A, Kunisada T.
Two distinct types of mouse melanocyte: differential signaling requirement for the maintenance of non-cutaneous and dermal versus epidermal melanocytes. 
Development 136(15):2511-21. 2009

19.) Takahashi K, Narita M, Yokura M, Ichisaka T, Yamanaka S.
Human induced pluripotent stem cells on autologous feeders.
PLoS One 4:e8067, 2009

18.) Nagata S, Toyoda M, Yamaguchi S, Hirano K, Makino H, Nishino K, Miyagawa Y, Okita H, Kiyokawa N, Nakagawa M, Yamanaka S, Akutsu H, Umezawa A, Tada T.
Efficient reprogramming of human and mouse primary extra-embryonic cells to pluripotent stem cells.
Genes Cells 14:1395-1404, 2009

17.) Nakamura K, Salomonis N, Tomoda K, Yamanaka S,
Conklin, BR. Gi-Coupled GPCR Signaling Controls the Formation and Organization of Human Pluripotent Colonies.
PLoS One 4: e7780, 2009

16.) Niwa A, Umeda K, Chang H, Saito M, Okita K, Takahashi K, Nakagawa M, Yamanaka S, Nakahata T, Heike T.
Orderly hematopoietic development of induced pluripotent stem cells via Flk-1+ hemoangiogenic progenitors.
J Cell Physiol 221:367-377, 2009

15.) Iwawaki T, Akai R, Yamanaka S, Kohno K.
Function of IRE1 alpha in the placenta is essential for placental development and embryonic viability.
PNAS 106:16657-16662, 2009

14.) Nishimura K, Nakagawa T, Ono K, Ogita H, Sakamoto T, Yamamoto N, Okita K, Yamanaka S, Ito J.
Transplantation of mouse induced pluripotent stem cells into the cochlea.
Neuroreport 20(14):1250–1254, 2009

13.) Yoshida Y, Takahashi K, Okita K, Ichisaka T, Yamanaka S.
Hypoxia Enhances the Generation of Induced Pluripotent Stem Cells.
Cell Stem Cell 5(3):237-241, 2009

12.) Yokoo N, Baba S, Kaichi S, Niwa A, Mima T, Doi H, Yamanaka S, Nakahata T, Heike T.
The effects of cardioactive drugs on cardiomyocytes derived from human induced pluripotent stem cells.
Biochem Biophys Res Commun 387:482-488, 2009

11.) Silva J, Nichols J, Theunissen TW, Guo G, van Oosten AL, Barrandon O, Wray J, Yamanaka S, Chambers I, Smith A.
Nanog is the gateway to the pluripotent ground state.
Cell 138(4):722-737, 2009

10.) Hong H, Takahashi K, Ichisaka T, Aoi T, Kanagawa O, Nakagawa M, Okita K, Yamanaka S.
Suppression of induced pluripotent stem cell generation by the p53–p21 pathway.
Nature 460:1132-1135, 2009

9.) Miura K, Okada Y, Aoi T, Okada A, Takahashi K, Okita K, Nakagawa M, Koyanagi M, Tanabe K, Ohnuki M, Ogawa D, Ikeda E, Okano H, Yamanaka S.
Variation in the safety of induced pluripotent stem cell lines.
Nat Biotech 27:743-745, 2009

8.) Tanaka T, Tohyama S, Murata M, Nomura F, Kaneko T, Chen H, Hattori F, Egashira T, Seki T, Ohno Y, Koshimizu U, Yuasa S, Ogawa S, Yamanaka S, Yasuda K, Fukuda K.
In vitro pharmacologic testing using human induced pluripotent stem cell-derived cardiomyocytes.
Biochem Biophys Res Commun 385:497-502, 2009

7.) Taura, D., Sone, M., Homma, K., Oyamada, N., Takahashi, K., Tamura, N., Yamanaka, S., Nakao, K.
Induction and isolation of vascular cells from human-induced pluripotent stem cells.
Arterioscler Thromb Vasc Biol 29:1100-1103, 2009

6.) Hirami Y, Osakada F, Takahashi K, Okita K, Yamanaka S, Ikeda H, Yoshimura N, Takahashi M.
Generation of retinal cells from mouse and human inducd plurootent stem cells.
Neurosci Lett. 458:126-131, 2009

5.) Tsubooka N, Ichisaka T, Okita K, Takahashi K, Nakagawa M, Yamanaka S.
Roles of Sall4 in the generation of pluripotent stem cells from blastocysts and fibroblasts.
Genes Cells 14: 683-694, 2009

4.) Senju S, Haruta M, Matsunga Y,Fukushima S, Ikeda T, Takahashi K, Okita K, Yamanaka S, Nishimura Y.
Characterization of dendritic cells and macrophages generated by directed differentiation from mouse induced pluriotent stem cells.
Stem Cells 27(5):1021-31, 2009

3.) Daley GQ, Lensch NW, Jaenische R, Meissner A, Plath K, Yamanaka S.
Broader implications of defining standards for the pluripotency of iPSCs.
Cell Stem Cell 4(3):200-1, 2009

2.) Taura D, Noguchi M, Sone M., Hosoda K, Mori E, Okada Y, Takahashi K, Homma K, Oyamada N, Inuzuka M, Sonoyama T, Ebihara K, Tamura N, Itoh H, Suemori H, Nakatsuji N, Okano H, Yamanaka S, Nakao K.
Adipogenic differentiation of human induced pluripotent stem cells:comparison with that of human embryonic stem cells.
FEBS Lett. 583:1029-1033, 2009

1.) Aiba, K, Nedorezov, T, Piao Y, Nishiyama A, Matoba R, Sharova LV, Sharov AA, Yamanaka S, Niwa H, and Ko MS.
Defining developmental potency and cell lineage trajectories by expression profiling of differentiating mouse embryonic stem cells.
DNA Res 16: 73-80, 2009

2008年

11.) Tanaka Y, Nakamura S, Shibata H, Kishi Y, Ikeda T, Masuda S, Sasaki K, Abe T, Hayashi S, Kitano Y, Nagao Y, Hanazono Y.
Sustained macroscopic engraftment of cynomolgus embryonic stem cells in xenogeneic large animals after in utero transplantation.
Stem Cells Dev 17: 367-382, 2008

10.) Kishi Y, Inoue M, Tanaka Y, Shibata H, Masuda S, Ikeda T, Hasegawa M, Hanazono Y.
Knockout Serum Replacement (KSR) has a suppressive effect on Sendai virus-mediated transduction of cynomolgus ES cells. Cloning and Stem Cells 10: 307-312, 2008

9.) Kishi Y, Tanaka Y, Shibata H, Nakamura S, Takeuchi K, Masuda S, Ikeda T, Muramatsu S, Hanazono Y.
Variation in the incidence of teratomas after the transplantation of non-human primate ES cells into immunodeficient mice.
Cell Transplant 17: 1095-1102, 2008

8.) Aoki H, Hara A, Motohashi T, Chem H, Kunisada T.
Iris as a recipient tissue for pigment cells: Organized in vivo differentiation of melanocytes and pigmented epithelium derived from embryonic stem cells in vitro.
Dev Dyn 237: 2394-2404, 2008

7.) Tsuji Y, Yoshimura N, Aoki H, Sharov AA, Ko MS, Motohashi T, Kunisada T.
Maintenance of undifferentiated mouse embryonic stem cells in suspension by the serum- and feeder-free defined culture condition.
Dev Dyn 237: 2129-2138, 2008

6.) Aoki H, Yoshida H, Hara A, Suzuki T, Kunisada T.
Transplantation of melanocytes into iris: method for iris repigmentation.
Transplantation 85:492-494, 2008

5.) Oyama T, Yamada Y, Hata K, Tomita H, Hirata A, Sheng HQ, Hara A, Aoki H, Kunisada T, Yamashita S, Mori H.
Further upregulation of β-catenin/Tcf transcription is involved in the development of macroscopic tumors in the colon of Apc Min/+ mice.
Carcinogenesis 29:666-672, 2008

4.) Hara A, Aoki H, Taguchi A, Niwa M, Yamada Y, Kunisada T, Mori H.
Neuron-like Differentiation and Selective Ablation of Undifferentiated Embryonic Stem Cells Containing Suicide Gene with Oct-4 Promoter.
Stem Cells Dev 17(4):619-27, 2008

3.) Takeda T, Tezuka Y, Horiuchi M, Hosono K, Iida K, Hatakeyama D, Miyaki S, Kunisada T, Shibata T, Tezuka K.
Characterization of Dental Pulp Stem Cells of Human Tooth Germs.
J Dent Res 87:676-681, 2008

2.) Okita K, Nakagawa M, Hong H, Ichisaka T, Yamanaka S.
Generation of mouse induced pluripotent stem cells without viral vectors.
Science 322: 949-953, 2008

1.) Narazaki G, Uosaki H, Teranishi M, Okita K, Kim B, Matsuoka S, Yamanaka S, Yamashita JK.
Directed and systematic differentiation of cardiovascular cells from mouse induced pluripotent stem cells.
Circulation 2008, 118:498-506, 2008

▲トップへ戻る

山中伸弥の受賞一覧

2012年度:

4.)ノーベル生理学・医学賞   2012年12月

3.)文化勲章   2012年11月

2.)京都府特別栄誉賞   2012年10月

1.)フィンランド技術アカデミー財団ミレニアム技術賞グランド・プライズ   2012年6月

2011年度:

6.)ISSCR McEwen Centre Award for Innovation (高橋和利博士と共同受賞)  2011年6月

5.)National Academy of Science USA 外国人会員(選出)   2011年5月

4.)アルバニー・メディカル・センター賞   2011年3月

3.)ウルフ賞(医学部門)(イスラエル・ウルフ財団)   2011年2月

2.)Frontiers of Knowledge Awards生物医学部門賞(スペインBBVA財団)   2011年2月

1.)King Faisal International Prize(キング・ファイサル国際賞)   2011年1月

2010年度:

10.)Warren Triennial Prize(マサチューセッツ総合病院)   2010年12月

9.)日本医師会医学賞   2010年11月

8.)文化功労者顕彰   2010年11月

7.)2010年トムソン・ロイター引用栄誉賞   2010年9月

6.)京都市民栄誉賞   2010年9月

5.)The 2010 Balzan Prize   2010年9月

4.)第26回(2010)京都賞 先端技術部門   2010年6月

3.)平成22年度日本学士院 恩賜賞・日本学士院賞   2010年6月

2.)2010 March of Dimes Prize in Developmental Biology   2010年5月

1.)大阪市長特別表彰   2010年4月

2009年度:

8.)2009 Canada Gairdner International Award   2009年10月

7.)2009 Albert Lasker Basic Medical Research Award   2009年10月

6.)日経BP技術賞 読者大賞   2009年4月

5.)Lewis S. Rosenstiel Award   2009年3月

4.)第2回日本薬理学会 江橋節郎賞   2009年3月

3.)平成20年度上原賞   2009年3月

2.)平成20年度島津賞   2009年2月

1.)関西元気文化圏賞 大賞   2009年1月

2008年度:

14.)京都新聞大賞 文化学術賞   2008年11月

13.)Meira and Shaul G. Massry Prize   2008年11月

12.)平成20年秋の紫綬褒章   2008年11月

11.)2008年度 武田医学賞   2008年9月

10.)京都創造者大賞2008 特別賞   2008年9月

9.)Shaw Prize 2008   2008年9月

8.)第6回高峰記念三共賞   2008年7月

7.)第61回(平成20年)中日文化賞   2008年5月

6.)The 2008 TIME 100選出   2008年5月

5.)平成20年度 科学技術分野の文部科学大臣表彰 科学技術特別賞   2008年4月

4.)2008年 日経BP技術賞大賞   2008年4月

3.)Robert Koch Prize 2008   2008年2月

2.)第24回(平成19年度)井上学術賞   2008年2月

1.)2007年度 朝日賞   2008年1月

2007年度:

4.)German Cancer Research Center (DKFZ) Meyenburg Foundation Award 2007  2007年11月

3.)第25回(平成19年度)大阪科学賞   2007年11月

2.)2007年 日経BP技術賞 医療・バイオ部門 部門賞 2 007年4月

1.)第3回(平成18年度)日本学術振興会賞  2007年3月

2006年度:

1.)科学技術への顕著な貢献 in 2006(ナイス ステップな研究者) 2006年12月

2004年度:

1.)東京テクノフォーラム21賞 第10回ゴールド・メダル賞  2004年 4月

2003年度:

1.)NAIST学術賞  2003年 7月

▲トップへ戻る

プロジェクト関係者受賞一覧

2012年度:

8.)水上喜久(花園グループ):第15回日本異種移植研究会 最優秀講演賞 2012年12月

7.)高橋和利(山中グループ):ニューヨーク幹細胞財団ロバートソン賞 2012年10月

6.)前 伸一(長船グループ):第32回分子腎臓フォーラム優秀賞 2012年9月

5.)新田 卓(花園グループ):第105回日本繁殖生物学会 優秀発表賞 2012年9月

4.)長船健二(山中グループ):第55回日本腎臓学会学術総会会長賞 2012年6月

3.)阿部朋行(花園グループ):第59回日本実験動物学会総会 若手優秀発表賞 2012年5月

2.)長船健二(山中グループ):第85回日本組織培養学会大会奨励賞 2012年5月

1.)Tamaoki N et al(國貞グループ):AADR/IADR Williams J. Gies Award Biological Research 2012年3月

2011年度:

3.)増田茂夫(花園グループ):日本遺伝子治療学会 学会賞 2011年7月

2.)高橋和利(山中グループ):ISSCR McEwen Centre Award for Innovation (山中総括と共同受賞) 2011年6月

1.)日栁章彦(鳥居グループ):日本生殖再生医学会 奨励賞 2011年3月

2010年度:

3.)鳥居隆三(鳥居グループ):日本実験動物学会 安東・田嶋賞 2010年5月

2.)高橋和利(山中グループ):東京テクノフォーラム21 ゴールドメダル賞 2010年4月

1.)増田茂夫(花園グループ):日本再生医療学会 若手研究奨励賞 (YIA) 2010年3月

2009年度:

3.)井上治久(井上グループ):2009年度ノバルティス老化および老年医学研究基金 2009年10月

2.)高橋和利(山中グループ):京都大学湯川・朝永奨励賞 2009年7月

1.)長船健二(山中グループ):CKD Award 2009 奨励賞 2009年6月

▲トップへ戻る