Creation of essential technologies to utilize carbon dioxide as a resource through the enhancement of plant productivity and the exploitation of plant products

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Nobutaka Hirano (Associate Professor, College of Engineering, Nihon University)

Creation of cooperative action by the accumulation and proximity of cellulose-, hemicellulose-, and lignin-degrading enzymes

 Creation of cooperative action between cellulose-, hemicellulose-, and lignin-degrading enzymes is important for development of an efficient enzymatic saccharification process of plant biomass in the production of next-generation renewable biofuels. In this study, we address to elucidation of relationship between the enzymatic composition and saccharification activity of cellulosome, a multienzyme complex that exhibits a high degradation activity for the sugar fraction of plant biomass, and creation of an underlying technology for generating cooperative action between cellulosome and lignin-degrading enzymes.


Nobutaka Hirano, Hiroki Hasegawa, Satoshi Nihei, Mitsuru Haruki, Cell-free protein synthesis and substrate specificity of full-length endoglucanase CelJ (Cel9D-Cel44A), the largest multi-enzyme subunit of the Clostridium thermocellum cellulosome, FEMS Microbiology Letters, vol. 344, 25-30 (2013)