Generation of Pluripotent Stem Cells by Protein Transduction Therapy
Professor, Faculty of Medical and Pharmaceutical Sciences,
Induced pluripotent stem (iPS) cells have been generated from human skin cells by the retroviral transduction of four transcription factors. However, retroviral transduction has some safety problems, such as toxicity of virus-vector itself and random integration of viral vector DNA into the host chromosomes. In the project, we generate iPS cells from human skin cells by protein transduction therapy. The goal of this project is the development of a novel technique by which we generate iPS cells safety.