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Kasuga, M., Karlsson, F.A. and Kahn, C.R. Insulin stimulates the phosphorylation of the 95K subunits of its own receptor. (1982) Science. 215: 185-187.
Kasuga, M., Zick, Y., Blithe, D.L., Crettaz, M. and Kahn, C.R. Insulin stimulates tyrosine phosphorylation of the insulin receptor in a cell-free system. (1982) Nature. 298: 667-669.
Kasuga, M., Fujita-Yamaguchi, Y., Blithe, D. and Kahn, C.R. Tyrosine-specific protein kinase activity is associated with the purified insulin receptor. (1983) Proc. Natl. Acad. Sci. USA. 80: 2137-2141.
Kadowaki, T., Kasuga, M., Akanuma, Y., Ezaki,O. and Takaku, F. Decreased autophosphorylation of the insulin receptor-kinase in streptozotocin-diabetic rats. (1984) J. Biol. Chem. 259: 14208-14216.
Odawara, M., Kadowaki, T., Yamamoto, R., Shibasaki, Y., Tobe, K., Accili, D., Bevins, C., Mikami, Y., Matsuura, N., Akanuma, Y., Takaku, F., Taylor, S.I. and Kasuga, M. Human Diabetes associated with a mutation in the tyrosine kinase domain of the insulin receptor. (1989) Science 245: 66-68.
Kotani, K., Yonezawa, K., Hara, K., Ueda, H., Ido, Y., Sakaue, H., Ando, A., Chavanieu, A., Calas, B., Grigorescu, F., Nishiyama, M., Waterfield, M.D. and Kasuga, M. Involvement of phosphoinositide 3-kinase in insulin or IGF-1-induced membrane ruffling. (1994) EMBO J. 13: 2313-2321.
Ando, A., Yonezawa, K., Gout, I., Nakata, T., Ueda, H., Hara, K., Kitamura, Y., Noda, Y., Takenawa, T., Hirokawa, N., Waterfield, M.D. and Kasuga, M. A complex of GRB2-dynamin binds to tyrosine-phosphorylated insulin receptor substrate-1 after insulin treatment. (1994) EMBO J. 13: 3033-3038.
Hara, K., Yonezawa, K., Sakaue, H., Ando, A., Kotani, K., Kitamura, Y., Ueda, H., Stephens, L., Jackson, T.R., Hawkins, P.T., Dhand, R., Clark, A.E., Holman, G.D., Waterfield, M.D. and Kasuga, M. Phosphoinositide 3-kinase activity is required for insulin-stimulated glucose transport but not for ras activation in CHO cells. (1994)Proc. Natl. Acad. Sci.USA. 91: 7415-7419.
Noguchi, T., Matozaki, T., Horita, K., Fujioka, Y. and Kasuga, M. Role of SH-PTP2, a protein-tyrosine phosphatase with Src homology-2 domains, in insulin-stimulated Ras activation. (1994) Mol. Cell. Biol. 14: 6674-6682.
Sakaue, M., Bowtell, D. and Kasuga, M. A dominant-negative mutant of mSOS1 inhibits insulin-induced ras activation and reveals ras-dependent and-independent insulin signaling pathways. (1995) Mol. Cell. Biol. 15: 379-388.
Noguchi, T., Matozaki, T., Inagaki, K., Tsuda, M., Fukunaga, K., Kitamura, Y., Kitamura, T., Shii, K., Yamanashi, Y., and Kasuga, M. Tyrosine phosphorylation of p62 Dok induced by cell adhesion and insulin: possible role in cell migration. (1999) EMBO J. 18: 1748-1760.
Kitamura, T., Kitamura, Y., Kuroda, S., Hino, Y., Ando, M., Kotani, K., Konishi, H., Matsuzaki, H., Kikkawa, U., Ogawa, W., and Kasuga M. Insulin-induced phosphorylation and activation of cyclic nucleotide phosphodiesterase (PDE) 3B by the serine-threonine kinase Akt (1999) Mol. Cell. Biol. 19: 6286-6296.
Sakaue, H., Konishi, M., Ogawa, W., Asaki, T., Mori, T., Yamasaki, M., Takata, M., Ueno, H., Kato, S., Kasuga, M., Itoh, N. Requirement of fibroblast growth factor10 in development of white adipose tissue. (2002) Genes Dev. 16:908-912.
Matsumoto, M., Ogawa, W., Teshigawara, K., Inoue, H., Miyake, K., Sakaue, H., Kasuga, M. Role of the IRS-1 and PI 3-kinase signaling pathway in insulin-induced expression of SREBP-1c and glucokinase genes in rat hepatocytes. (2002) Diabetes 51:1672-1680.
Miyake, K., Ogawa, W., Mastumoto, M., Nakamura, T., Sakaue, H., Kasuga, M.
Hyperinsulinemia, glucose intolerance, and dyslipidemia induced by acute inhibition of phosphoinositide 3-kinase signaling in the liver. (2002) J. Clin. Invest. 110:1483-1491.
Matsumoto, M., Ogawa, W., Akimoto K., Inoue, H., Miyake, K., Furukawa, K., Hayashi, Y., Iguchi, H., Matsuki, Y., Hiramatsu, R., Shimano, H., Yamada, N., Ohno, S., Kasuga, M. and Noda, T. Protein kinase Cλ in liver mediates insulin-induced SREBP-1c expression and determines both hepatic lipid content and overall insulin sensitivity. (2003) J. Clin. Invest. 112:935-944.
Inoue, H., Ogawa, W., Ozaki, M., Haga, S., Matsumoto, M., Furukawa, K., Hashimoto, N., Kido, Y., Mori, T., Sakaue, H., Teshigawara, K., Jin, S., Iguchi, H., Hiramatsu, R., Leroith, D., Takeda, K., Akira, S and Kasuga, M. Role of STAT-3 in regulation of hepatic gluconeogenic genes and of carbohydrate metabolism in vivo. (2004) Nature Med. 10:168-174.
Hashimoto N, Kido Y, Uchida T, Matsuda T, Suzuki K, Inoue H, Matsumoto M, Ogawa W, Maeda S, Fujihara H, Ueta Y, Uchiyama Y, Akimoto H, Ohno S, Noda T, and Kasuga M. PKCλ regulates glucose-induced insulin secretion through modulation of gene expression in pancreatic beta cells. (2005) J. Clin. Invest. 115:138-145.
Kanda H, Tamori Y, Shinoda H, Yoshikawa M, Sakaue M, Udagawa J, Otani H, Tashiro F, Miyazaki J, and Kasuga M. Adipocytes from Munc18c-null mice show increased sensitivity to insulin-stimulated GLUT4 externalization. (2005) J. Clin. Invest. 115:291-301.
Uchida T, Nakamura T, Hashimoto N, Matsuda T, Kotani K, Sakaue H, Hayashi Y, Nakayama KI, White MF, and Kasuga M. Deletion of Cdkn1b gene ameliorates hyperglycemia by maintaining compensatory hyperinsulinemia in diabetic mice. (2005) Nature Med. 11:175-182.
Hashimoto, N., Kido, Y., Uchida, T., Asahara, S., Shigeyama, Y., Matsuda, T., Takeda, A., Tsuchihashi, D., Nishizawa, A., Ogawa, W., Fujimoto, Y., Okamura, H., Arden, KC., Herrera, PL., Noda, T and Kasuga, M. Ablation of PDK1 in pancreatic βcells induces Diabetes as a result of loss of β-cell mass. (2006) Nature Genet. 38:589-593.
Inoue, H., Ogawa, W., Asakawa1, A., Okamoto, Y., Nishizawa, A., Matsumoto, M., Teshigawara, K., Matsuki, Y., Watanab2, E., Hiramatsu, R., Notohara, K., Katayose, K., Okamura, H., Kahn, CR., Noda, T., Takeda, K., Akira, S., Inui, A and Kasuga, M. Role of hepatic STAT3 in brain insulin action on hepatic glucose production. (2006) Cell Met. 3:267-275.
Kanda, H., Tateya, S., Tamori, Y., Kotani, K., Hiasa, K., Kitazawa, R., Kitazawa, S., Miyachi, H., Maeda, S., Egashira, K and Kasuga, M. MCP-1 contributes to macrophage infiltration into adipose tissue, insulin resistance, and hepatic steatosis in obesity. (2006) J. Clin. Invest. 116:1494-1505.
Hosooka, T., Noguchi, T., Kotani, K., Nakamura, T., Sakaue, H., Inoue, H., Ogawa, W., Tobimatsu, K., Takazawa, K., Sakai, M., Matsuki, Y., Hiramatsu, R., Yasuda, T., Lazar, MA., Yamanashi, Y., and Kasuga, M. Dok1 mediates high-fat diet-induced adipocyte hypertrophy and obesity through modulation of PPAR-g phosphorylation. (2008) Nature Med. 14:188-193.
Yasuda, K., Miyake, K., Horikawa, Y., Hara, K., Osawa, H., Furuta, H., Hirota, Y., Mori, H., Jonsson, A., Sato, Y., Yamagata, K., Hinokio, Y., Wang, HY. Tanahashi, T., Nakamura, N., Oka, Y., Iwasaki, N., Iwamoto, Y., Yamada, Y., Seino, Y., Maegawa, H., Kashiwagi, A., Takeda, J., Maeda, E., Shin, H.D., Cho, Y.M., Park, K.S., Lee, H.K., Ng, M., Ma, R., So, WY., Chan, J. Lyssenko, V., Tuomi, T., Nilsson, P., Groop, L., Kamatani, N., Sekine, A., Nakamura, Y., Yamamoto, K., Yoshida, T., Tokunaga, K., Itakura, M., Makino, H., Nanjo, K., Kadowaki, T. & Kasuga, M. Variants in KCNQ1 are associated with susceptibility to type 2 Diabetes mellitus. (2008) Nature Genet.40:1092-1097.
Matsuda T, Kido Y, Asahara S, Kaisho T, Tanaka T, Hashimoto N, Shigeyama Y, Takeda A, Inoue T, Shibutani Y, Koyanagi M, Hosooka T, Matsumoto M, Inoue H, Uchida T, Koike M, Uchiyama Y, Akira S, Kasuga, M. Ablation of C/EBPβ alleviates ER stress and pancreatic β cell failure through induction of GRP78. (2010) J Clin Invest.120: 115-126
Sakai M., Matsumoto M., Tujimural T., Yongheng C., Noguchi T., Inagaki K., Inoue H., Hosooka T., Takazawa K., Kido Y., Yasuda K., Hiramatsu R., Matsuki Y., Kasuga M. CITED2 links hormonal signaling to PGC-lα acetylation in regulation ofgluconeogenesis. (2012) Nature Med.18:612-617