Identification of novel physiologically active substances involved in enhancement or disturbance of human homeostasis
Kumiko Saeki
Research Site | National Center for Global Health and Medicine |
Research Institute, Department of Disease Control |
Division Chief |
Content
There remains numerous unsolved issues regarding the regulation of human homeostasis due to lack of appropriate experimental tools. By applying our unique and innovative techniques to produce high-quality brown adipocytes and vascular endothelial cells from human ES/iPS cells, I will identify novel physiologically active substances that are involved in enhancing or disturbing human homeostasis for the development of side-effect-free therapeutics for metabolic syndrome and ischemic diseases, which are recognized as a social problem.
Publication
- Nishio M, Nakahara M, Sato C, Saeki K, Akutsu H, Umezawa A, Tobe K, Yasuda K, Yuo A, Saeki K. New categorization of human vascular endothelial cells by pro- versus anti-proliferative phenotypes. World J Transl Med 4: 88-100, 2015.
- Nakahara M, Nishio M, Saeki K, You A, Saeki K. p38 MAPK regulates type-I versus type-II phenotyping of human vascular endothelial cells. World J Transl Med 4: 101-112, 2015.
- Nishio M, Nakahara M, Saeki K, Fujiu K, Iwata H, Manabe I, Yuo A, Saeki K. Pro- versus anti-stenotic capacities of type-I versus type-II human iPS-derived endothelial cells. World J Transl Med 4: 113-122, 2015.