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Elucidate the Parkinson's disease pathogenesis from a viewpoint of mitochondrial homeostatic control

Noriyuki Matsuda (photo)

Noriyuki Matsuda

Research Site Tokyo Metropolitan Institute of Medical Science
Department of Advanced Science for Biomolecules
Associate Director Researcher

Content

Degradation of low-quality mitochondria carried out by PINK1 and Parkin plays an essential role in the maintenance of mitochondrial homeostasis. It is now believed that the collapse of this mechanism leads to the hereditary recessive Parkinson's disease. In this study, I elucidate the long-lasting mystery in this field, i.e. the molecular mechanism how Parkin is transferred to the low-quality mitochondria during homeostatic control.