Elucidate the Parkinson's disease pathogenesis from a viewpoint of mitochondrial homeostatic control
||Tokyo Metropolitan Institute of Medical Science|
|Department of Advanced Science for Biomolecules|
|Associate Director Researcher|
Degradation of low-quality mitochondria carried out by PINK1 and Parkin plays an essential role in the maintenance of mitochondrial homeostasis. It is now believed that the collapse of this mechanism leads to the hereditary recessive Parkinson's disease. In this study, I elucidate the long-lasting mystery in this field, i.e. the molecular mechanism how Parkin is transferred to the low-quality mitochondria during homeostatic control.
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