Molecular Understanding of Regulation for Energy Metabolism Controlled by Bone

Masahiro Shinohara

Research Site	Tokyo Medical and Dental University
	Graduate School of Medical and Dental Sciences
	Junior Associate Professor

Content

Aging or breakdown of healthy lifestyle is associated with metabolic diseases such as osteoporosis, and obesity/diabetes. Bone has been known as a part of the locomoter system, but recent studies suggest that the bone tissue regulates energy metabolisms. In this study, I try to reveal the molecular mechanisms underlying the regulation of energy metabolism by the bone system, and establish a future pharmacological intervention for the metabolic diseases.

Publication

1. Ohmae S, Noma N, Toyomoto M, Shinohara M, Takeiri M, Fuji H, Takemoto K, Iwaisako K, Fujita T, Takeda N, Kawatani M, Aoyama M, Hagiwara M, Ishihama Y, Asagiri M. Actin-binding protein coronin 1A controls osteoclastic bone resorption by regulating lysosomal secretion of cathepsin K. Sci Rep, 7, 41710, 2017
2. Koda N, Sato T, Shinohara M, Ichinose S, Ito Y, Nakamichi R, Kayama T, Kataoka K, Suzuki H, Moriyama K, Asahara H. Mohawk transcription factor regulates homeostasis of the periodontal ligament. Development, 144, 313-320, 2017
3. Suzuki H, Ito Y, Shinohara M, Yamashita S, Ichinose S, Kishida A, Oyaizu T, Kayama T, Nakamichi R, Koda N, Yagishita K, Lotz MK, Okawa A, Asahara H. Gene targeting of the transcription factor Mohawk in rats causes heterotropic ossification of Achilles tendon via failed tenogenesis. Proc Natl Acad Sci USA, 113, 7840-7845, 2016.
4. Sumiya E, Negishi-Koga T, Nagai Y, Suematsu A, Suda T, Shinohara M, Sato K, Sanjo H, Akira S, Takayanagi H*. Phosphoproteomic analysis of kinase-deficient mice reveals multiple TAK1 targets in osteoclast differentiation. Biochem Biophys Res Commun, 463, 1284-1290, 2015