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Research Supervisor

Research Supervisor:Masato Kasuga

Masato Kasuga

Research SitePresident, National Center for Global health and Medicine
Degree obtainedDoctor of Medicine
Area of expertiseInternal medicine、Metabolomics diabetes

Positions held

Resident (Internal Medicine)University of Tokyo Hospital, Hongo
Fellow (Internal Medicine)University of Tokyo Hospital, Hongo
Clinical Research Fellow (Endocrinology and Metabolism) The Third Department of Internal Medicine Faculty of Medicine, University of Tokyo
Fogarty International Fellow in Diabetes Branch, NIAMDD, N.I.H. Bethesda, Maryland
Research Associate in Elliott P. Joslin Research Laboratory,Joslin Diabetes Center, Boston, Massachussetts,
Research Associate in Medicine Brigham and Women’Hospital, Harvard Medical School, Boston, Massachusetts,
Assistant Professor in MedicineThe Third Department of Internal Medicine Faculty of Medicine, University of Tokyo
Associate Professor in Medicine The Third Department of Internal Medicine Faculty of Medicine, University of Tokyo
Professor and Chairman in Medicine The Second Department of Internal Medicine Kobe University School of Medicine
Professor and Chairman in Medicine Division of Diabetes, Digestive and Kidney Diseases Department of Clinical Molecular Medicine Kobe University Graduate School of Medicine
Director, Kobe University Hospital
Professor and Chairman in Medicine Diabetes, Metabolism and Endocrinology,Department of Clinical Molecular Medicine Kobe University Graduate School of Medicine
Director-General, Research Institute,International Medical Center of Japan, Tokyo
Director Diabetes Research Center,Director-General, Research Institute,Director,National Center for Global Health and Medicine
Director Diabetes Research Center,Director-General, Research Institute,President,National Center for Global Health and Medicine


Shionogi-Lilly Award from the Japan Diabetes Society
Research-Encouragement Award from the Japan Endocrine Society
Encouraging Award of the Japanese Society of Internal Medicine
Mochida Memorial Scientific Award
Erwin Von Balz Preis from Boehringer Ingelheim
City of Hope Rachmiel Levine Visiting Professor
Philip Godfrey Memorial Lecture from British Biochemical Society
Hagedorn Award from the Japan Diabetes Society
Medical Award of the Japan Medical Association
Medical Award of Takeda Science Foundation
Medal with Purple Ribbon
The Japan Endocrine Society Award
Dr. Michael Brownlee Visiting Professor Lectureship at Joslin Diabetes Center
Japan Society for the Study of Obesity Award
Claude Bernard Prize of European Association for the Study of Diabetes
Manpei Suzuki International Prize for Diabetes Research

Academic activities

Japan Diabetes Society
President(May 2008 through May 2002)
Director(May 1997-present)
Japan Endocrine Society
Director(June 2005 to June 2001)
Japan Society of Obesity
Director(January 2002-present)
Japan Society Clinical Molecular Medicine
President(March 2012 to July 2008)
Director(April 1998-present)
Japanese Society of Internal Medicine
Councilor(March 2008 through April 1990)

Research funding

  1. Creative Scientific Research of Ministry of Education, Culture, Sports, Science Heisei 18-22 year
    "Insulin signaling network and its integration at the level of individual" research leader
  2. "Genome" Applied MEXT Grant-in-Aid for Scientific Research on Priority Areas year Heisei 17-21
    "Application to the identification of disease-related genes and medical diabetes" research leader
  3. 21st Century COE program of MEXT year Heisei 15-19
    "Signaling disease base that was modeled after" Diabetes Leader
  4. "Genomic Medicine" MEXT Grant-in-Aid for Scientific Research on Priority Areas year Heisei 12-16
    "Identification of genes involved in the insulin resistance of the Japanese" research leader
  5. Promotion Program, Japan Society for the Promotion of Science Research for the Future Academic year Heisei 9-13
    "- In the heart of the mechanism of the transmission mechanism of insulin signaling and its role in signal transduction downstream lipid kinase, PI3 kinase of" Project Leader」


Major publication list

  1. Kasuga, M., Kahn, C.R., Hedo, J-A., Van Obberghen, E. and Yamada, K.M. Insulin-induced receptor loss in cultured human lymphocytes is due to accelerated receptor degradation. (1981) Proc. Natl. Acad. Sci. USA. 78: 6917-6921.
  2. Kasuga, M., Karlsson, F.A. and Kahn, C.R. Insulin stimulates the phosphorylation of the 95K subunits of its own receptor. (1982) Science. 215: 185-187.
  3. Kasuga, M., Zick, Y., Blithe, D.L., Crettaz, M. and Kahn, C.R. Insulin stimulates tyrosine phosphorylation of the insulin receptor in a cell-free system. (1982) Nature. 298: 667-669.
  4. Kasuga, M., Fujita-Yamaguchi, Y., Blithe, D. and Kahn, C.R. Tyrosine-specific protein kinase activity is associated with the purified insulin receptor. (1983) Proc. Natl. Acad. Sci. USA. 80: 2137-2141.
  5. Kadowaki, T., Kasuga, M., Akanuma, Y., Ezaki,O. and Takaku, F. Decreased autophosphorylation of the insulin receptor-kinase in streptozotocin-diabetic rats. (1984) J. Biol. Chem. 259: 14208-14216.
  6. Odawara, M., Kadowaki, T., Yamamoto, R., Shibasaki, Y., Tobe, K., Accili, D., Bevins, C., Mikami, Y., Matsuura, N., Akanuma, Y., Takaku, F., Taylor, S.I. and Kasuga, M. Human Diabetes associated with a mutation in the tyrosine kinase domain of the insulin receptor. (1989) Science 245: 66-68.
  7. Kotani, K., Yonezawa, K., Hara, K., Ueda, H., Ido, Y., Sakaue, H., Ando, A., Chavanieu, A., Calas, B., Grigorescu, F., Nishiyama, M., Waterfield, M.D. and Kasuga, M. Involvement of phosphoinositide 3-kinase in insulin or IGF-1-induced membrane ruffling. (1994) EMBO J. 13: 2313-2321.
  8. Ando, A., Yonezawa, K., Gout, I., Nakata, T., Ueda, H., Hara, K., Kitamura, Y., Noda, Y., Takenawa, T., Hirokawa, N., Waterfield, M.D. and Kasuga, M. A complex of GRB2-dynamin binds to tyrosine-phosphorylated insulin receptor substrate-1 after insulin treatment. (1994) EMBO J. 13: 3033-3038.
  9. Hara, K., Yonezawa, K., Sakaue, H., Ando, A., Kotani, K., Kitamura, Y., Ueda, H., Stephens, L., Jackson, T.R., Hawkins, P.T., Dhand, R., Clark, A.E., Holman, G.D., Waterfield, M.D. and Kasuga, M. Phosphoinositide 3-kinase activity is required for insulin-stimulated glucose transport but not for ras activation in CHO cells. (1994) Proc. Natl. Acad. Sci. USA. 91: 7415-7419.
  10. Noguchi, T., Matozaki, T., Horita, K., Fujioka, Y. and Kasuga, M. Role of SH-PTP2, a protein-tyrosine phosphatase with Src homology-2 domains, in insulin-stimulated Ras activation. (1994) Mol. Cell. Biol. 14: 6674-6682.
  11. Sakaue, M., Bowtell, D. and Kasuga, M. A dominant-negative mutant of mSOS1 inhibits insulin-induced ras activation and reveals ras-dependent and-independent insulin signaling pathways. (1995) Mol. Cell. Biol. 15: 379-388.
  12. Noguchi, T., Matozaki, T., Inagaki, K., Tsuda, M., Fukunaga, K., Kitamura, Y., Kitamura, T., Shii, K., Yamanashi, Y., and Kasuga, M. Tyrosine phosphorylation of p62 Dok induced by cell adhesion and insulin: possible role in cell migration. (1999) EMBO J. 18: 1748-1760.
  13. Kitamura, T., Kitamura, Y., Kuroda, S., Hino, Y., Ando, M., Kotani, K., Konishi, H., Matsuzaki, H., Kikkawa, U., Ogawa, W., and Kasuga M. Insulin-induced phosphorylation and activation of cyclic nucleotide phosphodiesterase (PDE) 3B by the serine-threonine kinase Akt (1999) Mol. Cell. Biol. 19: 6286-6296.
  14. Sakaue, H., Konishi, M., Ogawa, W., Asaki, T., Mori, T., Yamasaki, M., Takata, M., Ueno, H., Kato, S., Kasuga, M., Itoh, N. Requirement of fibroblast growth factor10 in development of white adipose tissue. (2002) Genes Dev. 16:908-912.
  15. Matsumoto, M., Ogawa, W., Teshigawara, K., Inoue, H., Miyake, K., Sakaue, H., Kasuga, M. Role of the IRS-1 and PI 3-kinase signaling pathway in insulin-induced expression of SREBP-1c and glucokinase genes in rat hepatocytes. (2002) Diabetes 51:1672-1680.
  16. Miyake, K., Ogawa, W., Mastumoto, M., Nakamura, T., Sakaue, H., Kasuga, M. Hyperinsulinemia, glucose intolerance, and dyslipidemia induced by acute inhibition of phosphoinositide 3-kinase signaling in the liver. (2002) J. Clin. Invest. 110:1483-1491.
  17. Matsumoto, M., Ogawa, W., Akimoto K., Inoue, H., Miyake, K., Furukawa, K., Hayashi, Y., Iguchi, H., Matsuki, Y., Hiramatsu, R., Shimano, H., Yamada, N., Ohno, S., Kasuga, M. and Noda, T. Protein kinase Cλ in liver mediates insulin-induced SREBP-1c expression and determines both hepatic lipid content and overall insulin sensitivity. (2003) J. Clin. Invest. 112:935-944.
  18. Inoue, H., Ogawa, W., Ozaki, M., Haga, S., Matsumoto, M., Furukawa, K., Hashimoto, N., Kido, Y., Mori, T., Sakaue, H., Teshigawara, K., Jin, S., Iguchi, H., Hiramatsu, R., Leroith, D., Takeda, K., Akira, S and Kasuga, M. Role of STAT-3 in regulation of hepatic gluconeogenic genes and of carbohydrate metabolism in vivo. (2004) Nature Med. 10:168-174.
  19. Hashimoto N, Kido Y, Uchida T, Matsuda T, Suzuki K, Inoue H, Matsumoto M, Ogawa W, Maeda S, Fujihara H, Ueta Y, Uchiyama Y, Akimoto H, Ohno S, Noda T, and Kasuga M. PKCλ regulates glucose-induced insulin secretion through modulation of gene expression in pancreatic beta cells. (2005) J. Clin. Invest. 115:138-145.
  20. Kanda H, Tamori Y, Shinoda H, Yoshikawa M, Sakaue M, Udagawa J, Otani H, Tashiro F, Miyazaki J, and Kasuga M. Adipocytes from Munc18c-null mice show increased sensitivity to insulin-stimulated GLUT4 externalization. (2005) J. Clin. Invest. 115:291-301.
  21. Uchida T, Nakamura T, Hashimoto N, Matsuda T, Kotani K, Sakaue H, Hayashi Y, Nakayama KI, White MF, and Kasuga M. Deletion of Cdkn1b gene ameliorates hyperglycemia by maintaining compensatory hyperinsulinemia in diabetic mice. (2005) Nature Med. 11:175-182.
  22. Hashimoto, N., Kido, Y., Uchida, T., Asahara, S., Shigeyama, Y., Matsuda, T., Takeda, A., Tsuchihashi, D., Nishizawa, A., Ogawa, W., Fujimoto, Y., Okamura, H., Arden, KC., Herrera, PL., Noda, T and Kasuga, M. Ablation of PDK1 in pancreatic βcells induces Diabetes as a result of loss of β-cell mass. (2006) Nature Genet. 38:589-593.
  23. Inoue, H., Ogawa, W., Asakawa1, A., Okamoto, Y., Nishizawa, A., Matsumoto, M., Teshigawara, K., Matsuki, Y., Watanab2, E., Hiramatsu, R., Notohara, K., Katayose, K., Okamura, H., Kahn, CR., Noda, T., Takeda, K., Akira, S., Inui, A and Kasuga, M. Role of hepatic STAT3 in brain insulin action on hepatic glucose production. (2006) Cell Met. 3:267-275.
  24. Kanda, H., Tateya, S., Tamori, Y., Kotani, K., Hiasa, K., Kitazawa, R., Kitazawa, S., Miyachi, H., Maeda, S., Egashira, K and Kasuga, M. MCP-1 contributes to macrophage infiltration into adipose tissue, insulin resistance, and hepatic steatosis in obesity. (2006) J. Clin. Invest. 116:1494-1505.
  25. Hosooka, T., Noguchi, T., Kotani, K., Nakamura, T., Sakaue, H., Inoue, H., Ogawa, W., Tobimatsu, K., Takazawa, K., Sakai, M., Matsuki, Y., Hiramatsu, R., Yasuda, T., Lazar, MA., Yamanashi, Y., and Kasuga, M. Dok1 mediates high-fat diet-induced adipocyte hypertrophy and obesity through modulation of PPAR-g phosphorylation. (2008) Nature Med. 14:188-193.
  26. Yasuda, K., Miyake, K., Horikawa, Y., Hara, K., Osawa, H., Furuta, H., Hirota, Y., Mori, H., Jonsson, A., Sato, Y., Yamagata, K., Hinokio, Y., Wang, HY. Tanahashi, T., Nakamura, N., Oka, Y., Iwasaki, N., Iwamoto, Y., Yamada, Y., Seino, Y., Maegawa, H., Kashiwagi, A., Takeda, J., Maeda, E., Shin, H.D., Cho, Y.M., Park, K.S., Lee, H.K., Ng, M., Ma, R., So, WY., Chan, J. Lyssenko, V., Tuomi, T., Nilsson, P., Groop, L., Kamatani, N., Sekine, A., Nakamura, Y., Yamamoto, K., Yoshida, T., Tokunaga, K., Itakura, M., Makino, H., Nanjo, K., Kadowaki, T. & Kasuga, M. Variants in KCNQ1 are associated with susceptibility to type 2 Diabetes mellitus. (2008) Nature Genet.40:1092-1097.
  27. Matsuda T, Kido Y, Asahara S, Kaisho T, Tanaka T, Hashimoto N, Shigeyama Y, Takeda A, Inoue T, Shibutani Y, Koyanagi M, Hosooka T, Matsumoto M, Inoue H, Uchida T, Koike M, Uchiyama Y, Akira S, Kasuga, M. Ablation of C/EBPβ alleviates ER stress and pancreatic β cell failure through induction of GRP78. (2010) J Clin Invest.120: 115-126
  28. Sakai M., Matsumoto M., Tujimural T., Yongheng C., Noguchi T., Inagaki K., Inoue H., Hosooka T., Takazawa K., Kido Y., Yasuda K., Hiramatsu R., Matsuki Y., Kasuga M. CITED2 links hormonal signaling to PGC-lα acetylation in regulation ofgluconeogenesis. (2012) Nature Med.18:612-617